Comparative evaluation of parasitology and serological tests in the diagnosis of visceral leishmaniasis in India: a phase III diagnostic accuracy study

2006 ◽  
Vol 0 (0) ◽  
pp. 061127095204008-??? ◽  
Author(s):  
S. Sundar ◽  
R. K. Singh ◽  
S. K. Bimal ◽  
K. Gidwani ◽  
A. Mishra ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Diagnostic Accuracy ◽  
Comparative Evaluation ◽  
Phase Iii ◽  
Diagnostic Accuracy Study ◽  
Serological Tests ◽  
Accuracy Study

scholarly journals A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo

EBioMedicine ◽  
2018 ◽  
Vol 27 ◽  
pp. 11-17 ◽  
Author(s):  
Marleen Boelaert ◽  
Deby Mukendi ◽  
Emmanuel Bottieau ◽  
Jean Roger Kalo Lilo ◽  
Kristien Verdonck ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Human African Trypanosomiasis ◽  
Democratic Republic ◽  
Phase Iii ◽  
Diagnostic Accuracy Study ◽  
Second Stage ◽  
Republic Of The Congo ◽  
Accuracy Study

scholarly journals Molecular Profiling Improves Classification and Prognostication of Nodal Peripheral T-Cell Lymphomas: Results of a Phase III Diagnostic Accuracy Study

2013 ◽  
Vol 31 (24) ◽  
pp. 3019-3025 ◽  
Author(s):  
Pier Paolo Piccaluga ◽  
Fabio Fuligni ◽  
Antonio De Leo ◽  
Clara Bertuzzi ◽  
Maura Rossi ◽  
...  
Keyword(s):  
T Cell ◽  
Diagnostic Accuracy ◽  
Cell Lymphoma ◽  
Phase Iii ◽  
Support Vector ◽  
Index Test ◽  
Diagnostic Accuracy Study ◽  
T Cell Lymphomas ◽  
Accuracy Study ◽  
Peripheral T Cell Lymphomas

PurposeThe differential diagnosis among the commonest peripheral T-cell lymphomas (PTCLs; ie, PTCL not otherwise specified [NOS], angioimmunoblastic T-cell lymphoma [AITL], and anaplastic large-cell lymphoma [ALCL]) is difficult, with the morphologic and phenotypic features largely overlapping. We performed a phase III diagnostic accuracy study to test the ability of gene expression profiles (GEPs; index test) to identify PTCL subtype.MethodsWe studied 244 PTCLs, including 158 PTCLs NOS, 63 AITLs, and 23 ALK-negative ALCLs. The GEP-based classification method was established on a support vector machine algorithm, and the reference standard was an expert pathologic diagnosis according to WHO classification.ResultsFirst, we identified molecular signatures (molecular classifier [MC]) discriminating either AITL and ALK-negative ALCL from PTCL NOS in a training set. Of note, the MC was developed in formalin-fixed paraffin-embedded (FFPE) samples and validated in both FFPE and frozen tissues. Second, we found that the overall accuracy of the MC was remarkable: 98% to 77% for AITL and 98% to 93% for ALK-negative ALCL in test and validation sets of patient cases, respectively. Furthermore, we found that the MC significantly improved the prognostic stratification of patients with PTCL. Particularly, it enhanced the distinction of ALK-negative ALCL from PTCL NOS, especially from some CD30+ PTCL NOS with uncertain morphology. Finally, MC discriminated some T-follicular helper (Tfh) PTCL NOS from AITL, providing further evidence that a group of PTCLs NOS shares a Tfh derivation with but is distinct from AITL.ConclusionOur findings support the usage of an MC as additional tool in the diagnostic workup of nodal PTCL.

scholarly journals Evaluation of Nine Commercial Serological Tests for the Diagnosis of Human Hepatic Cyst Echinococcosis and the Differential Diagnosis with Other Focal Liver Lesions: A Diagnostic Accuracy Study

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 167
Author(s):  
Francesca Tamarozzi ◽  
Silvia Stefania Longoni ◽  
Ambra Vola ◽  
Monica Degani ◽  
Stefano Tais ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Diagnostic Accuracy ◽  
Diagnostic Algorithm ◽  
Solid Content ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Diagnostic Accuracy Study ◽  
Liquid Content ◽  
Serological Tests ◽  
Accuracy Study

The differential diagnosis of hepatic cystic echinococcosis (CE) may be challenging. When imaging is insufficient, serology can be applied, but no consensus diagnostic algorithm exists. We evaluated the performances of nine serological tests commercialized in Europe for the diagnosis of “echinococcosis”. We performed a diagnostic accuracy study using a panel of sera from patients with hepatic CE (n = 45 “liquid” content stages, n = 25 “solid” content stages) and non-CE focal liver lesions (n = 54 with “liquid” content, n = 11 with “solid” content). The diagnosis and staging of CE were based on ultrasound (gold standard). Nine commercial seroassays (5 ELISA, 2 WB, 1 Chemiluminescence Immunoassay [CLIA] and 1 Immunochromatographic test [ICT]) were the index tests. Sensitivity (Se) ranged from 43 to 94% and from 31 to 87%, and specificity (Sp) from 68 to 100% and from 94 to 100%, when borderline results were considered positive or negative, respectively. Three seroassays (2 ELISA, 1 WB) were excluded from further analyses due to poor performances. When tests were combined, Sp was 98–100%. The best results were obtained using the WB-LDBIO alone (Se 83%) or as a third test after two non-WB tests (Se 67–86%). A validated WB or two non-WB tests, read with stringent criteria (borderline = negative and considered positive only if concordant positive), possibly confirmed by the WB, appear sensible approaches.

Performance of The Truenat Tuberculosis and Rifampicin-Resistance Assays in the Microscopy Centre: A Prospective Multicentre Diagnostic Accuracy Study

2020 ◽  
Author(s):  
Adam Penn-Nicholson ◽  
Sivaramakrishnan N. Gomathi ◽  
César Ugarte-Gil ◽  
Abyot Meaza ◽  
Evelyn Lavu ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Rifampicin Resistance ◽  
Diagnostic Accuracy Study ◽  
Accuracy Study
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