Expression of Bcl-2 in human breast cancer: Correlation between hormone receptor status, p53 protein accumulation and DNA strand breaks associated with apoptosis

1997 ◽  
Vol 47 (11) ◽  
pp. 757-762 ◽  
Author(s):  
Masao Hori ◽  
Tatsuya Nogami ◽  
Masayuki Itabashi ◽  
Fuyo Yoshimi ◽  
Hisayuki Ono ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Human Breast Cancer ◽  
P53 Protein ◽  
Dna Strand Breaks ◽  
Hormone Receptor Status ◽  
Protein Accumulation ◽  
Human Breast ◽  
Strand Breaks ◽  
Dna Strand

Steroid hormone receptor activity of primary human breast cancer and pattern of first metastasis

1991 ◽  
Vol 18 (1) ◽  
pp. 27-32 ◽  
Author(s):  
P. G. Koenders ◽  
L. V. A. M. Beex ◽  
R. Langens ◽  
P. W. C. Kloppenborg ◽  
A. G. H. Smals ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Human Breast Cancer ◽  
Steroid Hormone ◽  
Receptor Activity ◽  
Steroid Hormone Receptor ◽  
Human Breast ◽  
Primary Human Breast

scholarly journals ARF induction in response to DNA strand breaks is regulated by PARP1

2013 ◽  
Vol 42 (4) ◽  
pp. 2320-2329 ◽  
Author(s):  
Giulia Orlando ◽  
Svetlana V. Khoronenkova ◽  
Irina I. Dianova ◽  
Jason L. Parsons ◽  
Grigory L. Dianov
Keyword(s):  
Dna Damage ◽  
Protein Function ◽  
P53 Protein ◽  
Dna Strand Breaks ◽  
Vital Role ◽  
Cellular Stress Response ◽  
Strand Breaks ◽  
Dna Strand ◽  
Cellular Dna ◽  
Arf Protein

Abstract The ARF tumour suppressor protein, the gene of which is frequently mutated in many human cancers, plays an important role in the cellular stress response by orchestrating up-regulation of p53 protein and consequently promoting cell-cycle delay. Although p53 protein function has been clearly linked to the cellular DNA damage response, the role of ARF protein in this process is unclear. Here, we report that arf gene transcription is induced by DNA strand breaks (SBs) and that ARF protein accumulates in response to persistent DNA damage. We discovered that poly(ADP-ribose) synthesis catalysed by PARP1 at the sites of unrepaired SBs activates ARF transcription through a protein signalling cascade, including the NAD+-dependent deacetylase SIRT1 and the transcription factor E2F1. Our data suggest that poly(ADP-ribose) synthesis at the sites of SBs initiates DNA damage signal transduction by reducing the cellular concentration of NAD+, thus down-regulating SIRT1 activity and consequently activating E2F1-dependent ARF transcription. Our findings suggest a vital role for ARF in DNA damage signalling, and furthermore explain the critical requirement for ARF inactivation in cancer cells, which are frequently deficient in DNA repair and accumulate DNA damage.

scholarly journals Diallyl sulfide inhibits PhIP-induced DNA strand breaks in normal human breast epithelial cells

2007 ◽  
Author(s):  
Chantell Wilson ◽  
Ayoola Aboyade-Cole ◽  
Oneil Newell ◽  
Selina Darling-Reed ◽  
Ebenezer Oriaku ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Dna Strand Breaks ◽  
Human Breast ◽  
Diallyl Sulfide ◽  
Breast Epithelial Cells ◽  
Strand Breaks ◽  
Normal Human Breast ◽  
Normal Human ◽  
Dna Strand ◽  
Human Breast Epithelial Cells

scholarly journals Gadd45a levels in human breast cancer are hormone receptor dependent

2013 ◽  
Vol 11 (1) ◽  
pp. 131 ◽  
Author(s):  
Jennifer S Tront ◽  
Alliric Willis ◽  
Yajue Huang ◽  
Barbara Hoffman ◽  
Dan A Liebermann
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Human Breast Cancer ◽  
Human Breast
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