Biomarkers of Oxidative Injury and Their Modulation in Prostatic Tissue from Patients With Prostate Cancer

2002 ◽  
Author(s):  
Theodore L. DeWeese
Keyword(s):  
Prostate Cancer ◽  
Oxidative Injury ◽  
Prostatic Tissue

scholarly journals Can mean ADC value and ADC ratio of benign prostate tissue to prostate cancer assist in the prediction of clinically significant prostate cancer within the PI-RADSv2 scoring system?

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Samar Ramzy Ragheb ◽  
Reem Hassan Bassiouny
Keyword(s):  
Prostate Cancer ◽  
Sensitivity And Specificity ◽  
Gleason Score ◽  
Treatment Strategies ◽  
Serum Levels ◽  
Prostatic Tissue ◽  
Histopathological Analysis ◽  
Adc Value ◽  
The Mean ◽  
Clinically Significant

Abstract Background The aim of this study is to investigate whether quantitative DW metrics can provide additive value to the reliable categorization of lesions within existing PI-RADSv2 guidelines. Fifty-eight patients with clinically suspicious prostate cancer who underwent PR examination, PSA serum levels, sextant TRUS-guided biopsies, and bi-parametric MR imaging were included in the study. Results Sixty-six lesions were detected by histopathological analysis of surgical specimens. The mean ADC values were significantly lower in tumor than non-tumor tissue. The mean ADC value inversely correlated with Gleason score of tumors with a significant p value < 0.001.Conversely, a positive relationship was found between the ADC ratio (ADC of benign prostatic tissue to prostate cancer) and the pathologic Gleason score with a significant elevation of the ADC ratio along with an increase of the pathologic Gleason score (p < 0.001). ROC curves constructed for the tumor ADC and ADC ratio helped to distinguish pathologically aggressive (Gleason score ≥ 7) from non-aggressive (Gleason score ≤ 6) tumors and to correlate it with PIRADSv2 scoring to predict the presence of clinically significant PCA (PIRADSv2 DW ≥ 4). The ability of the tumor ADC and ADC ratio to predict highly aggressive tumors (GS> 7) was high (AUC for ADC and ADC ratio, 0.946 and 0.897; p = 0.014 and 0.039, respectively). The ADC cut-off value for GS ≥ 7 was < 0.7725 and for GS ≤ 6 was > 0.8620 with sensitivity and specificity 97 and 94%. The cutoff ADC ratio for predicting (GS > 7) was 1.42 and for GS ≤ 6 was > 1.320 with sensitivity and specificity 97 and 92%. By applying this ADC ratio cut-off value the sensitivity and specificity of reader 1 for correct categorization of PIRADSv2 DW > 4 increased from 90 and 68% to 95 and 90% and that of reader 2 increased from 94 and 88% to 97 and 92%, respectively. Conclusion Estimation of DW metrics (ADC and ADC ratio between benign prostatic tissue and prostate cancer) allow the non-invasive assessment of biological aggressiveness of prostate cancer and allow reliable application of the PIRADSv2 scoring to determine clinically significant cancer (DW score > 4) which may contribute in planning initial treatment strategies.

scholarly journals Expression of SPANX proteins in normal prostatic tissue and in prostate cancer

2010 ◽  
Vol 54 (3) ◽  
pp. 41 ◽  
Author(s):  
M. Salemi ◽  
A. E. Calogero ◽  
G. Zaccarello ◽  
R. Castiglione ◽  
A. Cosentino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostatic Tissue

MP28-16 PROSTATIC TISSUE ANDROGEN LEVELS AS PROGNOSTIC FACTOR FOR MEN WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Yasuhide Miyoshi ◽  
Takashi Kawahara ◽  
Mari Ohtaka ◽  
Sohgo Tsutsumi ◽  
Koichi Uemura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Prostatic Tissue ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Androgen Levels

Prostate cancer in native Japanese and Japanese-American men: Effects of dietary differences on prostatic tissue

Urology ◽  
2004 ◽  
Vol 64 (4) ◽  
pp. 765-771 ◽  
Author(s):  
Leonard S. Marks ◽  
Munekado Kojima ◽  
Angelo Demarzo ◽  
David Heber ◽  
David G. Bostwick ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostatic Tissue ◽  
Japanese American

scholarly journals Frequency of Prostate Cancer Among the Prostatic Tissue Samples- Collected From Different Tertiary Level Hospital in Dhaka City

2020 ◽  
Vol 21 (2) ◽  
pp. 88-92
Author(s):  
Mohammad Mukhlesur Rahman ◽  
Muhammad Mahmud Alam ◽  
Mohammad Ohiduzzaman Khan ◽  
Mohammad Rezaul Karim ◽  
Md Sajid Hasan
Keyword(s):  
Prostate Cancer ◽  
Early Diagnosis ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Statistical Tests ◽  
The Body ◽  
Prostatic Tissue ◽  
Tertiary Level ◽  
Dhaka City ◽  
Prostatic Disease

Background: Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system. The cancer cells may spread from the prostate to other area of the body, particularly the bones and lymph nodes. It may initially cause no symptoms. A disease known as benign prostatic hyperplasiamay produce similar symptoms. Objective: To identify the frequency of prostate cancer in prostatic tissue submitted for histopathological examination in selected hospital of Dhaka City. Method: This analytical observational study consists of review of 3914 histopathological reports of prostatic specimen examined in 13 selected tertiary level hospitals in Dhaka city. This study was carried out from January 2007 to December 2009 (three years). All data were compiled, analyzed and appropriate statistical tests were done to make inference. Results: During the study period, among the 2914 histopathological specimen of prostatic tissue, 637(about 16%) cases were diagnosed as prostate cancer (including PIN), 3221 (about 82%) cases were benign prostatic hyperplasia, 53 (1 .35%) were chronic prostatitis and the remaining 3 cases were other rare disease e.g. lipid storage disease etc. Among the prostate cancer, most common was prostatic adenocarcinoma (about 95%); about 3% was Prostatic Intraepithelial Neoplasia (PIN), 1% squamous cell carcinoma arid I % are primary Transtiona1 cell carcinoma (TCC). Most of the patients diagnosed with prostate cancers are of advanced age - between 70 to 80 years (53.46%), and the second peak age is 60- 70 years (34.57 %). Of the prostate cancer cases 8.78% were well differentiated, 34.84% were moderately differentiated and 64.36% were poorly differentiated. The ratio between benign and malignant prostatic disease was about 5:1. Though all the prostatic diseases are common in elderly people, benign prostatic disease occurs more commonly: in younger patients than the prostate cancer. Conclusion: From this study it is evident that the burden of prostate cancer is still low in our context. But the disease seems to be increasing in recent years mainly due to increasing number of aged population. So in near future, the burden of the disease will be increasing throughout the world including our country. Prostate cancer is a slow growing tumor. It has a very sensitive tumor marker (PSA) also. Early diagnosis and proper management certainly improves the prognosis of the disease. There is a screening program for early diagnosis of the disease though it is relatively a costly program. Screening should be considered in persons who have a strong family history of prostate cancer. Every urologist, health policy makers should be aware of the burden of the disease and appropriate planning, necessary manpower & skill development, resource allocation should be made to combat the situation efficiently. Bangladesh Journal of Urology, Vol. 21, No. 2, July 2018 p.88-92

scholarly journals Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Paavo Raittinen ◽  
Kati Niemistö ◽  
Erika Pennanen ◽  
Heimo Syvälä ◽  
Seppo Auriola ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostatic Tissue ◽  
High Dose

1140: Evaluation of Adrenal Androgen and Estrogen Levels in the Prostatic Tissue with Prostate Cancer or Benign Prostatic Hyperplasia

2007 ◽  
Vol 177 (4S) ◽  
pp. 376-376
Author(s):  
Seiji Arai ◽  
Yasuhiro Shibata ◽  
Bunzo Kashiwagi ◽  
Seijiro Honma ◽  
Kazuhiro Suzuki
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Prostatic Tissue ◽  
Adrenal Androgen
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