RELATION BETWEEN CEREBRAL OXIDATIVE METABOLISM FOLLOWING BIRTH ASPHYXIA, AND NEURODEVELOPMENTAL OUTCOME AND BRAIN GROWTH AT ONE YEAR

2008 ◽  
Vol 34 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Simon C. Roth ◽  
A. David Edwards ◽  
Ernest B. Cady ◽  
David T. Delpy ◽  
John S. Wyatt ◽  
...  
Keyword(s):  
Oxidative Metabolism ◽  
Neurodevelopmental Outcome ◽  
Birth Asphyxia ◽  
Brain Growth ◽  
One Year ◽  
Cerebral Oxidative Metabolism

Neurodevelopmental outcome of healthy term newborn with serum bilirubin >15 mg/dl at one year

2020 ◽  
pp. 1-6
Author(s):  
P. Dubey ◽  
J. Shrivastava ◽  
B.P. Choubey ◽  
A. Agrawal ◽  
V. Thakur
Keyword(s):  
Serum Bilirubin ◽  
Tertiary Care ◽  
Neurodevelopmental Outcome ◽  
Significant Risk ◽  
Central India ◽  
Significant Risk Factor ◽  
Motor Domain ◽  
Medical Emergency ◽  
One Year ◽  
Group 1

BACKGROUND: Neonatal hyperbilirubinemia is a common medical emergency in early neonatal period. Unconjugated bilirubin is neurotoxic and can lead to lifelong neurological sequelae in survivors. OBJECTIVE: To find out the association between serum bilirubin and neurodevelopmental outcome at 1 year of age using Development Assessment Scale for Indian Infants (DASII). METHODS: A prospective cohort study was conducted in the Department of Pediatrics of a tertiary care institution of Central India between January 2018 and August 2019. Total 108 term healthy neonates, with at least one serum bilirubin value of >15 mg/dl, were included. Subjects were divided into three groups based on the serum bilirubin; group 1: (15–20 mg/dl) –85(78.7%) cases, group 2: (20–25 mg/dl) –17(15.7%), and group 3: (>25 mg/dl) –6(5.5%). Developmental assessment was done using DASII at 3, 6, 9, 12 months of age. RESULTS: Out of 108 cases, 101(93.5%) received phototherapy, and 7(6.5%) received double volume exchange transfusion. Severe delay was observed in 5(4.6%) and mild delay in 2(1.9%) cases in the motor domain of DASII at one year. Severe delay in the motor domain was associated with mean TSB of 27.940±2.89 mg/dl and mild delay with mean TSB of 22.75±1.76 mg/dl (p = 0.001). On cluster analysis, delay was observed in locomotion 1 score in 11(13%) cases (p = 0.003) and manipulation score in 6(7.1%) cases in group 1. CONCLUSION: Increased serum bilirubin was a significant risk factor for the delayed neurodevelopment in babies with neonatal jaundice. Even a moderate level of bilirubin significantly affects the developmental outcome.

Cerebral oxidative metabolism in fetal sheep with multiple-dose ethanol infusion

1987 ◽  
Vol 157 (6) ◽  
pp. 1496-1502 ◽  
Author(s):  
Bryan Richardson ◽  
John Patrick ◽  
Jacobus Homan ◽  
Lesley Carmichael ◽  
James Brien
Keyword(s):  
Oxidative Metabolism ◽  
Multiple Dose ◽  
Fetal Sheep ◽  
Ethanol Infusion ◽  
Cerebral Oxidative Metabolism

Ontogeny of Cerebral Oxidative Metabolism in the Chick Embryo

1982 ◽  
Vol 38 (5) ◽  
pp. 1387-1392 ◽  
Author(s):  
Teresa Gonya-Magee ◽  
Robert C. Vannucci
Keyword(s):  
Chick Embryo ◽  
Oxidative Metabolism ◽  
Cerebral Oxidative Metabolism

scholarly journals Neurodevelopmental Outcome of High Risk Babies at One Year of Age Born in a Tertiary Centre

2017 ◽  
Vol 37 (1) ◽  
pp. 45-50
Author(s):  
Merina Shrestha ◽  
Luna Bajracharya ◽  
Laxman Shrestha
Keyword(s):  
High Risk ◽  
Congenital Anomalies ◽  
Neonatal Period ◽  
Neurodevelopmental Outcome ◽  
Single Item ◽  
Tertiary Centre ◽  
Developmental Domains ◽  
One Year ◽  
High Risk Clinic

Introduction: With increasing survival of high risk babies, children with different developmental disabilities have emerged as a challenge for the baby, family as well as for physicians. With limited awareness and resources, follow-up and interventions for these babies are difficult. The study was carried out to find out the development of high risk babies in different developmental domains at one year of age.Material and Methods: NICU graduates who visited high risk clinic at one year of age were assessed. ASQ-3 was used to screen development. Children with major congenital anomalies and syndromes were excluded from the study.Results: Out of 28 high risk babies, about 29% had global delay. Those babies who had seizure during neonatal period could not score even in single item of ASQ-3. Conclusion: All high risk babies are at risk of developing delay hence should be followed up regularly. Timely early intervention needs to be started to minimize delay.  

scholarly journals Epidemiological determinants of infant deaths occurring in a teaching hospital: an observational study

2019 ◽  
Vol 6 (3) ◽  
pp. 1192
Author(s):  
M. N. Soumyashree ◽  
R. G. Viveki ◽  
Sunanda Halki
Keyword(s):  
Birth Asphyxia ◽  
Medical Sciences ◽  
Place Of Delivery ◽  
Demographic Profile ◽  
Infant Deaths ◽  
Live Births ◽  
Mother And Child Health ◽  
Common Causes ◽  
Mother And Child ◽  
One Year

Background: India has the highest number of infant deaths, contributing about 23% to the global burden of infant deaths. Sustainable development goal states that, by 2030, preventable deaths of new-borns and children under 5 years of age should be ended, with all countries aiming to reduce neonatal mortality to at least as low as 12 per 1000 live births and under-5 mortality to at least as low as 25 per 1000 live births. Aims of the study: (1) to understand the socio-demographic profile of the study cases, (2) to correlate the causes of infant deaths with age, parity and other obstetrics parameters.Methods: The present study was undertaken for the period of one year from January to December 2016. The study included 120 deceased infants from department of Pediatrics, Belagavi Institute of Medical Sciences (BIMS) Hospital, Belagavi. Information regarding socio-demographic profile, antenatal, intranatal and infant details were collected using a structured questionnaire.Results: 61.6% of study cases were male and three-fourth of them resided in rural area. 56.2% of the deceased infants were LBW, followed by VLBW (34.9%) and ELBW (8.9%).  The common causes of death among the deceased infants were prematurity (45%) followed by, birth asphyxia (34.2%), sepsis (12.5%), pneumonia (3.3%) and congenital anomalies and other (2.5%).Conclusions: Age of the infants, gestational age, place of delivery, delivery assisted and LBW were associated with infant deaths. There is a need for proper implementation of programmes related to mother and child health care.

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