Faculty Opinions recommendation of [CONFERENCE PRESENTATION]: Neurodevelopmental outcome among HIV-infected children older than one year of age randomized to immediate versus deferred ART: the PREDICT study.

BACKGROUND: Neonatal hyperbilirubinemia is a common medical emergency in early neonatal period. Unconjugated bilirubin is neurotoxic and can lead to lifelong neurological sequelae in survivors. OBJECTIVE: To find out the association between serum bilirubin and neurodevelopmental outcome at 1 year of age using Development Assessment Scale for Indian Infants (DASII). METHODS: A prospective cohort study was conducted in the Department of Pediatrics of a tertiary care institution of Central India between January 2018 and August 2019. Total 108 term healthy neonates, with at least one serum bilirubin value of >15 mg/dl, were included. Subjects were divided into three groups based on the serum bilirubin; group 1: (15–20 mg/dl) –85(78.7%) cases, group 2: (20–25 mg/dl) –17(15.7%), and group 3: (>25 mg/dl) –6(5.5%). Developmental assessment was done using DASII at 3, 6, 9, 12 months of age. RESULTS: Out of 108 cases, 101(93.5%) received phototherapy, and 7(6.5%) received double volume exchange transfusion. Severe delay was observed in 5(4.6%) and mild delay in 2(1.9%) cases in the motor domain of DASII at one year. Severe delay in the motor domain was associated with mean TSB of 27.940±2.89 mg/dl and mild delay with mean TSB of 22.75±1.76 mg/dl (p = 0.001). On cluster analysis, delay was observed in locomotion 1 score in 11(13%) cases (p = 0.003) and manipulation score in 6(7.1%) cases in group 1. CONCLUSION: Increased serum bilirubin was a significant risk factor for the delayed neurodevelopment in babies with neonatal jaundice. Even a moderate level of bilirubin significantly affects the developmental outcome.

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Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation

Journal of Pediatric Surgery ◽

10.1016/j.jpedsurg.2015.03.040 ◽

2015 ◽

Vol 50 (6) ◽

pp. 898-903 ◽

Cited By ~ 18

Author(s):

Enrico Danzer ◽

Marsha Gerdes ◽

Jo Ann D’Agostino ◽

Judy Bernbaum ◽

Casey Hoffman ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Congenital Diaphragmatic Hernia ◽

Diaphragmatic Hernia ◽

Neurodevelopmental Outcome ◽

Membrane Oxygenation ◽

One Year

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Neurodevelopmental Outcome of High Risk Babies at One Year of Age Born in a Tertiary Centre

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v37i1.16242 ◽

2017 ◽

Vol 37 (1) ◽

pp. 45-50

Author(s):

Merina Shrestha ◽

Luna Bajracharya ◽

Laxman Shrestha

Keyword(s):

High Risk ◽

Congenital Anomalies ◽

Neonatal Period ◽

Neurodevelopmental Outcome ◽

Single Item ◽

Tertiary Centre ◽

Developmental Domains ◽

One Year ◽

High Risk Clinic

Introduction: With increasing survival of high risk babies, children with different developmental disabilities have emerged as a challenge for the baby, family as well as for physicians. With limited awareness and resources, follow-up and interventions for these babies are difficult. The study was carried out to find out the development of high risk babies in different developmental domains at one year of age.Material and Methods: NICU graduates who visited high risk clinic at one year of age were assessed. ASQ-3 was used to screen development. Children with major congenital anomalies and syndromes were excluded from the study.Results: Out of 28 high risk babies, about 29% had global delay. Those babies who had seizure during neonatal period could not score even in single item of ASQ-3. Conclusion: All high risk babies are at risk of developing delay hence should be followed up regularly. Timely early intervention needs to be started to minimize delay.

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Effect of kangaroo mother care on neurodevelopmental outcome of low birth weight babies: a one-year randomized control trial

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20180545 ◽

2018 ◽

Vol 5 (2) ◽

pp. 508 ◽

Cited By ~ 1

Author(s):

Prathiba N. Doddabasappa ◽

N. S. Mahantshetti ◽

Mahesh Kamate ◽

Adarsh E.

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Muscle Tone ◽

Neurodevelopmental Outcome ◽

Kangaroo Mother Care ◽

Psychomotor Development ◽

Care Group ◽

Development Index ◽

Low Birth Weight Babies ◽

One Year

Background: Low birth weight (LBW) is one of the risk factor for neurodevelopmental delay. The present study was undertaken to assess the role of the Kangaroo Mother Care (KMC) in the neurodevelopmental outcome of low birth weight babies. Methods: The present study was undertaken at Department of Paediatrics, Jawarharlal Medical college, Belgaum during the period from January 2009 to October 2010. The study includes 80 stable LBW babies were randomized into 40 in the KMC group and 40 in convention method of care group. 36 babies in the KMC group and 33 babies in the CMC group completed the study. The Neurodevelopmental outcome was assessed by the Amiel Tison test at three, six, nine and twelfth months of age. This was compared with BSID test, at one year.Results: The neurosensory examination and passive muscle tone (PMT) were found to be abnormal. Majority of the babies in both groups has a normal neurosensory and PMT development at one year. Statistically significant to muscle tone deficit was observed in the CMC babies at six months and nine months (p = 0.005 and p = 0.013). With respect to BSID, 16 and 29 KMC babies had a normal Psychomotor Development Index (PDI) and Motor Development Index (MDI) scores when compared to 8 and 18 CMC babies (p = 0.003 and p = 0.057 respectively). Number of babies with significant delay was observed to be higher in the CMC group being 11 versus 1 for PDI scores and 4 versus 1 for MDI scores.Conclusions: The present study shows that KMC has a beneficial effect on the neurodevelopmental outcome of low birth weight babies and BSID II is a better test to detect the psychomotor and mental developmental delay when compared to the Amiel Tison test.

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