Associations of Motor Performance and Executive Functions: Comparing Children with Down Syndrome to Chronological and Mental Age-Matched Controls

Background. Children with Down syndrome (DS) exhibit lower motor and cognitive performance than typically developing children (TD). Although there is a relationship between these two developmental domains, only a few studies have addressed this association in children with DS compared to groups of the same chronological age (CA) or mental age (MA) within one study. This study aimed to fill this research gap. Method and Procedures. The Movement Assessment Battery for Children-2 and the Trail-Making Test was used to assess motor and cognitive performances in 12 children (M = 10.5 ± 10.08) with DS, 12 CA-matched, and 12 MA-matched controls. Results. There are significant group differences in the motor dimension (total test score; p < 0.001, η2p = 0.734), for processing speed (p < 0.001, η2p = 0.396), and cognitive flexibility (p < 0.001, η2p = 0.498). Between TD-CA and both other groups, the differences in the magnitude of correlations for the motor dimension balance are also significant (compared to DS: z = −2.489; p = 0.006, and to TD-MA: z = −3.12; p < 0.001). Conclusions. Our results suggest that the relationships depend on the studied cognitive and motor skills. It seems crucial to select a wide range of tasks for both domains that are as isolated as possible for future studies, to better understand the relationships between cognitive and motor skills in children with DS.

Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population

Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infants’ neurodevelopment in the context of co-occurring metals. Maternal metal exposure and select micronutrients’ concentrations were assessed using samples collected at the time of delivery from mothers living across Navajo Nation with community exposure to metal mixtures originating from abandoned uranium mines. Infants’ development across five domains was measured at ages 10 to 13 months using the Ages and Stages Questionnaire Inventory (ASQ:I), an early developmental screener. After adjusting for effects of other confounding metals and demographic variables, prenatal exposure to lead, arsenic, antimony, barium, copper, and molybdenum predicted deficits in at least one of the ASQ:I domain scores. Strontium, tungsten, and thallium were positively associated with several aspects of infants’ development. Mothers with lower socioeconomic status (SES) had higher lead, cesium, and thallium exposures compared to mothers from high SES backgrounds. These mothers also had infants with lower scores across various developmental domains. The current study has many strengths including its focus on neurodevelopmental outcomes during infancy, an understudied developmental period, and the use of a novel analytical method to control for the effects of co-occurring metals while examining the effect of each metal on neurodevelopmental outcomes. Yet, future examination of how the effects of prenatal exposure on neurodevelopmental outcomes unfold over time while considering all potential interactions among metals and micronutrients is warranted.

Pattern of Repetitive Element Transcription Segregate Cell Lineages during the Embryogenesis of Sea Urchin Strongylocentrotus purpuratus

Repetitive elements (REs) occupy a significant part of eukaryotic genomes and are shown to play diverse roles in genome regulation. During embryogenesis of the sea urchin, a large number of REs are expressed, but the role of these elements in the regulation of biological processes remains unknown. The aim of this study was to identify the RE expression at different stages of embryogenesis. REs occupied 44% of genomic DNA of Strongylocentrotus purpuratus. The most prevalent among these elements were the unknown elements—in total, they contributed 78.5% of REs (35% in total genome occupancy). It was revealed that the transcription pattern of genes and REs changes significantly during gastrulation. Using the de novo transcriptome assembly, we showed that the expression of RE is independent of its copy number in the genome. We also identified copies that are expressed. Only active RE copies were used for mapping and quantification of RE expression in the single-cell RNA sequencing data. REs expression was observed in all cell lineages and they were detected as population markers. Moreover, the primary mesenchyme cell (PMC) line had the greatest diversity of REs among the markers. Our data suggest a role for RE in the organization of developmental domains during the sea urchin embryogenesis at the single-cell resolution level.

Association between Exposure to Particulate Matter during Pregnancy and Multidimensional Development in School-Age Children: A Cross-Sectional Study in Italy

Air pollutants can potentially affect the development of children. However, data on the effect of exposure to air pollution during pregnancy and developmental outcomes in school children are rare. We investigated the link between prenatal exposure to particulate matters smaller than 10 microns (PM10) and the development of school-age children in multiple domains. Cross-sectional data were collected in Italy between 2013 and 2014. Children aged between 5 and 8 years (n = 1187) were assessed on cognitive, communication, socio-emotional, adaptive, and motor developmental domains using the Developmental Profile 3 questionnaire. The monthly average concentration of PM10 during the entire fetal period was linked to the municipality of residence of the children. The increase in the prenatal PM10 was associated with a decrease in the cognitive score during the second (+13.2 µg/m3 PM10 increase: −0.30 points; 95%CI: −0.12–−0.48) and third trimesters of pregnancy (−0.31 points; 95%CI: −0.11–−0.50). The communicative domain was also negatively influenced by PM10 increases in the second trimester. The development of cognitive and communicative abilities of children was negatively associated with the exposure to PM10 during the period of fetal development, confirming that exposure to air pollution during pregnancy can potentially hinder the development of the brain.

Neurodevelopmental Disabilities

An understanding of developmental disabilities requires a good understanding of normal childhood development. Developmental milestones are typically divided into different domains, such as gross motor, fine motor, language, and social/adaptive skills. Assessment of attained milestones across the developmental domains allows the examiner to evaluate potential cognitive outcome. Emotional development is also important at all ages.

Title: A Study to Assess the Knowledge among Parents Related to Aggression in School Going Children

Background: School going is a period of life with health and developmental needs and rights. It this period the children develop knowledge and skills, learn to manage emotions and relationships. The WHO defines school going from age 10 to 19 years. Investing in the world’s 1.2 billion school going can break cycles of poverty and inequity, highlights UNICEF in its 2011 State of the World’s Children report. Aggressive behaviors can obstruct instruction and success in a variety of interventions, preventing progress in a variety of developmental domains. Objectives: 1. To assess the knowledge among parents related to the aggression of school going children. 2. To determine the association between the knowledge score of parents with their demographic variables. Materials and Methods: This study was based on a descriptive approach, In this study 80 parents of school going children were selected from the rural area of Sawangi Meghe,Wardha District by using tool such as structured knowledge questionnaire with non-probability convenient sampling method data was collected. Results: The study showed that the mean percentage of knowledge score was 13.31±4.39 (44.36 %) according to the level of knowledge score regarding aggression among parents of school going children. 2.5% of the parents had poor, 42.5% had average, 45% had good knowledge score, 8.75% had very good knowledge score and 1.25% had excellent knowledge score. Conclusion: The present study is descriptive and aims to assess the knowledge regarding aggression among parents of school going children. Recommendation, we can study on Impact of the Aggression on student’s mental health and school performance.

Can Mother's Depression Affect Infant's Development?

Background: The mental state of the mother is one of the factors influencing the development of infants. Besides, the quality of the child's relationship with her/his parent is very important in childhood development. Objectives: This study aimed at investigating the relationship between the mother's depression and developmental disorders in infants. Methods: This cross-sectional study utilized a sample size of 311 subjects. The study population included all infants and their mothers who were referred to health centers of the city of Hamadan, Iran, to receive the usual one-year care. Mothers’ depression was assessed with the second edition of the Beck Depression Inventory, and children’s developmental disabilities were assessed with one-year Ages and Stages Questionnaire. Results: The mean age of mothers in this study was 29.7 ± 5.6. The prevalence of developmental disorders in infants was 3.5%. This study showed that mothers' depression had no significant relationship with any of the developmental domains in infants. None of the developmental domains in infants were related to the mother's occupation and education. However, the gross motor skills (P-value: 0.007) and problem-solving skills (P-value: 0.031) were significantly related to the socioeconomic level, and communication (P-value: 0.034), and personal-social skills (P-value: 0.026) of the infant were directly related to the mother's age. Conclusions: Mother's depression is not related to the infant's developmental disorders. There is a relationship between the socioeconomic level of the family and gross motor and problem-solving skills of the infant. The mother’s age is directly related to communication and personal-social skills of the infant.

Motor Development in Context

The study of motor development has traditionally focused on the timing and sequence of the acquisition of motor skills, such as sitting, crawling, or walking, over the first years of life. Because motor skills are directly observable, motor development serves as a useful exemplar for general principles of development. Current frameworks emphasize motor development in and as a context, such as how change in motor skill interacts with simultaneous change in other developmental domains, how the acquisition of new motor skills creates new opportunities for learning, and how the context in which motor development occurs shapes the course of development. For example, the onset of new motor skills changes the allocation of attentional resources, the quality of infants’ sleep, and available perceptual information. Reciprocally, contexts such as culturally specific parenting practices and individual differences in everyday experiences impact the timing and trajectory of new motor skills.

Agreement and Reliability of Parental Reports and Direct Screening of Developmental Outcomes in Toddlers at Risk

Developmental screening is a practice that directly benefits vulnerable and low-income families and children when it is regular and frequently applied. A developmental screening tool administered by parents called CARE is tested. CARE contains a compilation of activities to report and enhance development at home. Hundred and fifty-seven families in Bogotá (Colombia) initially responded to a call to participate in developmental screening tools’ validation and reliability study. All children (Average: 42.7 months old; SD: 9.4; Min: 24, Max: 58) were screened directly by trained applicants using a Spanish version of the Denver Developmental Screening test [i.e., the Haizea-Llevant (HLL) screening table]. After a first screening, 61 dyads were positive for follow-up and received a second HLL screening. Fifty-two out of 61 dyads use and returned CARE booklet after 1-month screening at home. The comparative analysis for parent reports using CARE and direct screening observation included (a) the effects of demographic variables on overall and agreement, (b) agreement and congruence between the CARE report classification and direct screening classification (“At risk” or “Not at risk”), (c) receiver operating characteristic analysis, (d) item-Level agreement for specific developmental domains, and (e) acceptability and feasibility analysis. Results and conclusions show the parental report using the CARE booklet as a reliable screening tool that has the potential to activate alerts for an early cognitive delay that reassure clinicians and families to further specialized and controlled developmental evaluations and act as a screen for the presence of such delay in four developmental dimensions.