Comparison of two malignancy risk indices based on serum CA125, ultrasound score and menopausal status in the diagnosis of ovarian masses

1999 ◽  
Vol 106 (6) ◽  
pp. 524-527 ◽  
Author(s):  
Giuseppe Morgante ◽  
Antonio Marca ◽  
Antonino Ditto ◽  
Vincenzo Leo
Keyword(s):  
Menopausal Status ◽  
Malignancy Risk ◽  
Risk Indices ◽  
Serum Ca125 ◽  
Ultrasound Score ◽  
Ovarian Masses

scholarly journals Diagnostic value of risk malignancy index (RMI) for detection of malignancies in clinically diagnosed ovarian masses and to evaluate the validity of individual constituent parameter of risk malignancy index

2019 ◽  
Vol 8 (4) ◽  
pp. 1558
Author(s):  
Jenitha B. ◽  
Subbiah M.
Keyword(s):  
Malignant Tumors ◽  
Menopausal Status ◽  
Research Centre ◽  
Ca 125 ◽  
Ovarian Mass ◽  
Individual Parameter ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Ovarian Masses

Background: Pre-operative knowledge regarding the nature of ovarian mass is necessary in order to plan surgery. Risk malignancy index (RMI) is a simple scoring system based on three factors serum CA 125, USG score and menopausal status. The RMI was interpreted as 1) score >250=high risk, 2) 25-250=intermediate risk, 3) score <25=low risk. The objective of the study was to evaluate risk malignancy index (RMI) in pre-operatively clinically diagnosed ovarian mass and to compare the validity of individual parameter in RMI i.e. menopausal status, serum CA 125 and USG score to differentiate the nature of clinically diagnosed ovarian masses as benign or malignant.Methods: This was an observational study conducted in the Department of obstetrics and gynaecology, Trichy SRM Medical College and Research Centre, Trichy from January 2017 to January 2018 with a sample size of 77 cases with clinical diagnosis of ovarian mass admitted for surgery. The validity of RMI and validity of individual parameters were calculated and compared.Results: A total of 77 patients with ovarian tumors were enrolled in this study. According to the histological examination of the surgical specimens of the 77 women, 27.3% (n=21) had malignant tumors and 67.7% (n=56) had benign disease. Most common benign tumour was serous cystadenoma and the most common malignant tumour was mucinous cystadenocarcinoma. Among 77 patients, 42.85% (n=33) were postmenopausal, 44.15% (n=34) had USG score of 4, 27.27% (n=21) had serum CA125 level >cut-off values and 27.27% (n=21) had RMI >250. In cases where RMI>250, 18 out of 21 were malignant. In cases where USG score was 4, 19 out of 34 were malignant. Of the cases where serum CA125 level was > cut-off values 16 out of 21 were found to be malignant. RMI showed better sensitivity of 85.71%, specificity of 94.64%, PPV of 85.71%, NPV of 94.64% and diagnostic accuracy of 92.20%.Conclusions: RMI is highly valuable and reliable in differentiating benign and malignant ovarian lesions and facilitates selection of cases for conservative management and oncology referral.

scholarly journals Predictive Value of Malignancy Risk Indices for Ovarian Masses in Premenopausal and Postmenopausal Women

2016 ◽  
Vol 17 (4) ◽  
pp. 2177-2183 ◽  
Author(s):  
Sinem Ertas ◽  
Fisun Vural ◽  
Ertugrul Can Tufekci ◽  
Ahmet Candost Ertas ◽  
Gultekin Kose ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Predictive Value ◽  
Malignancy Risk ◽  
Risk Indices ◽  
Ovarian Masses

scholarly journals The adnexal mass: Benign or malignant? Evaluation of risk of malignancy index

2016 ◽  
Vol 6 (2) ◽  
pp. 127
Author(s):  
Shamsun Nahar ◽  
Latifa Shamsuddin
Keyword(s):  
Adnexal Mass ◽  
Histopathological Examination ◽  
Menopausal Status ◽  
Abdominal Ultrasound ◽  
Ovarian Malignancy ◽  
Abdominal Ultrasonography ◽  
Serum Ca125 ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index ◽  
Ultrasound Score

<p><strong>Background:</strong> Screening programme for ovarian malignancy is an international public demand. <strong></strong></p><p><strong>Ojective:</strong> To validate a risk of malignancy index (RMI) incorporating serum CA125, abdominal ultrasound findings and menopausal status for preoperative diagnosis of ovarian malignancy among patient with adnexal mass.</p><p><strong>Methods:</strong> This prospective observa­tional study was conducted on 57 patients having adnexal mass admitted consecutively for surgical exploration in BSMMU from January 2000 to March 2001. S. CA125 assay &amp; abdominal ultrasonography was done within 10 days preoperatively. Ultrasound score (0, 1 &amp; 3) using 5 sonographic features &amp; menopausal score (1 &amp; 3) were calculated. RMI was detected by the formula "RMI = Ultrasound score - Menopausal score - S. CA125 level" Definitive diagnosis was based on histopathological examination.</p><p>See PDF for the rest of the abstract.</p>

scholarly journals Comparison of four malignancy risk indices in the detection of malignant ovarian masses

2011 ◽  
Vol 22 (3) ◽  
pp. 177 ◽  
Author(s):  
Erhan Aktürk ◽  
Rıza Efendi Karaca ◽  
İbrahim Alanbay ◽  
Murat Dede ◽  
Emre Karaşahin ◽  
...  
Keyword(s):  
Malignancy Risk ◽  
Risk Indices ◽  
Ovarian Masses

scholarly journals Sonographic Prediction of Ovarian Malignancy in Adnexal Mass

2016 ◽  
Vol 27 (2) ◽  
pp. 67-71
Author(s):  
Shamsun Nahar ◽  
Latifa Shamsuddin ◽  
Mariam Faruqui ◽  
Gulshan Ara
Keyword(s):  
Adnexal Mass ◽  
Menopausal Status ◽  
Ovarian Malignancy ◽  
Chi Square ◽  
Abdominal Ultrasonography ◽  
Predictive Values ◽  
Serum Ca125 ◽  
Ultrasound Score ◽  
Sensitivity Specificity

Objective: To evaluate the role of ultrasound for preoperative diagnosis of ovarian malignancy in adnexal mass.Materials & Methods: This prospective observational study was conducted on patients having adnexal mass (n-57) admitted consecutively for surgical exploration in Dept. of OB-GYN of BSMMU from January 2000 - March 2001. Abdominal ultrasonography was performed 10 days preoperatively and 5 sonographic criteria were used to calculate ultrasound score (0, 1 & 3 ). Definitive diagnosis was based on histo-pathological study . Sensitivity , specificity , positive and negative predictive values of ultrasound score to diagnose ovarian malignancy were detected . Chi square & student’s ‘t’ test were used for statistical analysis .Results: Sensitivity , specificity , positive and negative predictive values of ultrasound score at cut-off value of 3 were 78% , 80% , 47% and 94 % respectively .Conclusion: For pre-operative diagnosis of ovarian malignancy sonographic scoring system may be introduced easily into the clinical practice where other complementary tests are not available. Combination of serum CA125 and menopausal status into ultrasound score may further improve the diagnostic accuracy in prediction of ovarian malignancy preoperatively.Bangladesh J Obstet Gynaecol, 2012; Vol. 27(2) : 67-71

scholarly journals A prospective study of clinical and diagnostic methods of ovarian tumors admitted in a tertiary care hospital and its correlation with histopathology

2021 ◽  
Author(s):  
Silika Madria ◽  
Vineeta Ghanghoriya ◽  
Kavita N. Singh ◽  
Manisha Lokwani ◽  
Ranu Tiwari
Keyword(s):  
Clinical Diagnosis ◽  
Sensitivity And Specificity ◽  
Tertiary Care ◽  
Ovarian Tumors ◽  
Diagnostic Methods ◽  
Care Hospital ◽  
Ultrasound Score ◽  
Benign Ovarian Tumors ◽  
Sensitivity Specificity ◽  
Ovarian Masses

Background: Aim of the study was to study demographic profile and diagnostic modalities of ovarian tumors and their correlation with histopathological report (HPR).Methods: Prospective observational study conducted in NSCB medical college, Jabalpur from February 2019 to July 2020 on subjects with ultrasonographically diagnosed ovarian tumors. Relevant history obtained, gynecologic examination, investigations recorded. Subjects followed up to collection of HPR and correlation with histopathology done.Results: Out of 120 cases of ovarian tumors, 39.16% were malignant and 60.83% were benign ovarian tumors. Out of 80 premenopausal females, majority (78.75%) had benign ovarian masses. Amongst 40 postmenopausal females, 75% of ovarian masses were malignant. CA125 had sensitivity 76.59%, specificity 76.71% and accuracy 76.66% in diagnosing ovarian malignancy. Amongst 4 RMI scores, RMI 1 has the highest sensitivity and specificity 85.10%, 86.30% respectively. Sensitivity, specificity, and accuracy of ultrasound score was 65.21%, 86.30% and 77.5% respectively. Sensitivity and specificity of clinical diagnosis was 83% and 95.89% respectively and ROC analysis showed clinical diagnosis can accurately predict benign and malignant ovarian tumors in 89% cases.Conclusions: RMI 1 score has the highest sensitivity and specificity in our study. When all 4 methods of diagnosis i.e., RMI Score, ultrasound score, CA125 and clinical diagnosis were compared, clinical diagnosis has highest prediction of malignancy.

scholarly journals Comparison of three malignancy risk indices and CA-125 in the preoperative evaluation of patients with pelvic masses

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Zinatossadat Bouzari ◽  
Shahla Yazdani ◽  
Mahmoud Haji Ahmadi ◽  
Shahnaz Barat ◽  
Ziba Shirkhani Kelagar ◽  
...  
Keyword(s):  
Preoperative Evaluation ◽  
Ca 125 ◽  
Malignancy Risk ◽  
Risk Indices ◽  
Pelvic Masses

scholarly journals Diagnostic Accuracy and Appropriate Cut Off Value of Risk of Malignancy Index in Preoperative Discrimination Between Malignant and Benign Ovarian Tumors: Prospective Cross-sectional Study

2021 ◽  
Author(s):  
bezza Kedida Dabi ◽  
Fanta Asefa Disasa ◽  
Ayantu Kebede Olika
Keyword(s):  
Diagnostic Accuracy ◽  
Menopausal Status ◽  
Cross Sectional Study ◽  
Ovarian Tumors ◽  
Ca 125 ◽  
Benign Tumors ◽  
Cross Sectional ◽  
Malignant Ovarian Tumor ◽  
Ultrasound Score ◽  
Benign Ovarian Tumors

Abstract BackgroundRisk of malignancy index (RMI) is scoring system which was introduced to differentiate between benign and malignant ovarian tumor. It incorporates CA-125, ultrasound score and menopausal status for prediction of ovarian malignancies in preoperative period. There is no universal screening method to discriminate between benign and malignant adnexal masses yet. So, this study was conducted to determine the diagnostic accuracy of RMI and determine best cut off value for RMI.MethodsProspective cross-sectional study was carried out among women with ovarian mass admitted to Gynecology ward and operated from September 1, 2019 to June 30, 2020.Data analysis was carried out using SPSS version 26. CA-125 level, menopausal status and ultrasound score were used to calculate RMI. Finally, RMI score was compared to histopathology result used as gold standard.ResultsNinity nine patients were enrolled in this study. Prevalence of benign ovarian tumors were 61.6% (61/99) and that of malignant ovarian tumors were 38.4% (38/99). The mean age for benign tumors was 30±9yrs and the mean age for malignant tumors was 50.6±10.8yrs. Among benign tumors, serous cystadenoma was the most common (36%), followed by dermoid cyst (32.9%), mucinous cyst adenoma (14.8%). The most common malignant ovarian tumor was serous cyst adenocarcinoma (63.2%), followed by mucinous cystadenocarcinoma (23.8%) and dysgerminoma (5.3%). Overall, using RMI score cut off value 220 has good sensitivity (84.2%), specificity (77%), PPV (69.5%), NPV (88.7%) and diagnostic accuracy (79.8%) for discriminating between benign and malignant ovarian tumors.ConclusionFrom this study there were high proportion of women with RMI>=220 in malignant ovarian tumors group. The study shows that there is significant role of RMI in prediction of ovarian malignancy thus helping in deciding which patients need referral to a center where gynecologic oncologists are available. It is good practice to use it in developing countries including our country because of its simplicity, safety and applicability in initial evaluations of patients with adnexal mass.

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