The role of high resolution ultrasound with guided cytology of groin lymph nodes in the management of squamous cell carcinoma of the vulva: a pilot study

1999 ◽  
Vol 106 (8) ◽  
pp. 863-867 ◽  
Author(s):  
E. C. Moskovic ◽  
J. H. Shepherd ◽  
D. P. J. Barton ◽  
P. A. Trott ◽  
N. Nasiri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
High Resolution ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals The Role Of High Resolution Ultrasonography To Differentiate Between Benign And Malignant Cervical Lymph Nodes In Oral Squamous Cell Carcinoma

2018 ◽  
Vol 7 (2) ◽  
pp. 19-27
Author(s):  
Mohammad Asifur Rahman ◽  
Nasreen Sultana ◽  
Md Wares Uddin ◽  
Quazi Billur Rahman
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Resolution ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Lymph Nodes ◽  
High Resolution Ultrasonography

Objectives:The purpose of the study was to evaluate the role of high resolution ultrasonography to differentiate between benign and malignant cervical lymph nodes in oral squamous cell carcinoma.Materials & Methods:The study was conducted in the Department of Oral and Maxillofacial Surgery, BSMMU,Dhaka, Bangladesh, during a period of January -2010 to December - 2011. A total number of 41 patients with clinical evidence of palpable cervical lymph nodes in oral squamous cell carcinoma were evaluated with high resolution ultrasonography. To evaluate the diagnostic accuracy of high resolutionultrasonography, the high resolution ultrasonography findings were compared and correlat- ed with histopathological examination after neck dissection.Results: All patients were pre-operatively examined by palpation and high resolution ultrasonography evaluation was done.Among them 41 study subjects, on high resolution ultrasonography evaluation 23(56.09%) lymph nodes were metastatic and 18(43.90%) lymph nodes were reactive. After postop- erative excisional histopathology examination 22(53.66%) lymph nodes were metastatic and 19(46.34%) lymph nodes were reactive in nature. Correlation of vascular flow pattern with histopatho- logical diagnosis showed that central flow for benign nodes, mixed & peripheral flow for malignant nodes were highly significant parameters (P<0.001). High resolution ultrasonography has specificity 78.94%, sensitivity 86.36% and diagnostic accuracy of the high resolution ultrasonography was 82.92%.Conclusion: High resolution ultrasonography can plays a definite role as an adjunct to the clinical evaluation of palpable cervical lymph nodes and proves its value as an important noninvasive investi- gation procedure for differentiating between benign and malignant cervical lymph nodes in oral squa- mous cell carcinoma.Update Dent. Coll. j: 2017; 7 (2): 19-27

R412 – Role of KITENIN in Progression and Metastasis of SCC

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P181-P181
Author(s):  
Mark Zarrella ◽  
Joon Kyoo Lee MD ◽  
Sang-Chul Lim
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Vitro Assay ◽  
Transfected Cells ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

Problem The expression of KAI1 (a metastatic suppressor gene) in cancer cells results in reduced cell motility and invasiveness. A cDNA clone of VANGL1, a member of the tetraspanin protein family that specifically interacts with the COOH-terminal cytoplasm domain of KAI1, was isolated and renamed KITENIN (KAI1 COOH-terminal interacting tetraspanin). The purpose of this study was to investigate the role of KITENIN on the progression and metastasis of transfected squamous cell carcinoma using in vivo and in vitro experiments. Methods Locally advanced squamous cell carcinoma tissues from five patients were obtained for investigation of KITENIN expression. Malignant tumors, normal adjacent mucosa tissues, metastatic lymph nodes, and non-metastatic lymph nodes were collected. KITENIN or vector only (control) was transfected into SCC (squamous cell carcinoma) VII, a mouse squamous cell carcinoma cell line, using FuGENE 6. An in vitro assay (invasion, migration, and proliferation) for KITENIN and the vector-transfected group was studied. The KITENIN or vector-transfected SCC VII cells were injected subcutaneously into 12 C3H/HeJ syngeneic mice (6 mice for each group). The tumor size was measured daily for 4 weeks. During the fifth week after injection, the presence of metastasis in the lung and liver tissue was evaluated for each mouse with a tumor mass on the back; the tissues were assessed by gross and microscopic examination. Results KITENIN was highly expressed in tumors and metastatic lymph nodes from patients. KITENIN-transfected cells showed significantly increased invasion, migration, and proliferation compared with the vector-transfected cells. Tumor volume was more increased in the KITENIN-transfected cells-injected mice. Lung metastasis was found in the KITENIN-group (3/6 mice), while no metastasis in the vector-group. Conclusion KITENIN participates in the progression and metastasis of SCC. Significance An antisense KITENIN strategy may be a useful method to inhibit progression and metastasis in squamous cell carcinoma. Support This study was financially supported by Chonnam National University, 2006.

scholarly journals Role of abnormal Langerhans cells in oral epithelial dysplasia and oral squamous cell carcinoma: A pilot study

2015 ◽  
Vol 6 (3) ◽  
pp. 128 ◽  
Author(s):  
ShyamsundarVidya Rani ◽  
Babu Aravindha ◽  
Sankari Leena ◽  
Nandagopal Balachander ◽  
LetchumanaKumar Malathi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Langerhans Cells ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

scholarly journals Unresected Small Lymph Nodes Assessment Predict Prognosis For Patients With pT3N0M0 Thoracic Esophageal Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Yi Wang ◽  
Ping Xiao ◽  
Ningjing Yang ◽  
Xiang Wang ◽  
Ke Ma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox Regression ◽  
Negative Group ◽  
Cox Regression Analysis

Abstract Background: The role of unresected small lymph nodes (LNs) which may contain metastases for thoracic esophageal squamous cell carcinoma (TESCC) has not been addressed. The aim of the study was to investigate the role of unresected small LNs assessment using computed tomography (CT) in prognostic estimates of pT3N0M0 TESCC patients.Methods: Between January 2009 and December 2017, 294 patients who underwent esophagectomy with R0 resection at Sichuan Cancer Hospital were retrospectively examined, and the last follow-up time was July 2018. Patients were classified into CT-suspect and CT-negative groups according to the shortest diameter and the shape (axial ratio) of the unresected small LNs on preoperative CT. The Kaplan–Meier method was used to compare survival differences in prognostic factors. Univariate and multivariate analyses were performed to identify prognostic factors for survival and recurrence. Results: Eighty-four patients (42.5%) were classified as CT-suspect group according to the diagnostic criteria, survival analysis suggested that CT-suspect group of patients had a relatively poorer prognosis (P<0.05). Cox regression analysis indicated that unresected small LNs status, tumor grade, and postoperative adjuvant therapy were independent prognostic factors for patients with pT3N0M0 TESCC (P<0.05). Further analysis shown the rates of total recurrence (TR) and locoregional recurrence (LR) in the CT-suspect group were significantly higher than that in the CT-negative group (TR: P<0.000; LR: P<0.000). Among the LRs, the rate of supraclavicular lymph node recurrence in the CT-suspect group was significantly higher than that in the CT-negative group (P<0.000).Conclusions: Unresected small lymph nodes assessment is critically important and predict prognosis for pT3N0M0 TESCC patients.

Planned Neck Dissection after Definitive Radiotherapy or Chemoradiation for Base of Tongue Cancers

2007 ◽  
Vol 137 (3) ◽  
pp. 422-427 ◽  
Author(s):  
Ying J. Hitchcock ◽  
Brandon G. Bentz ◽  
Pramod K. Sharma ◽  
Christine Fang ◽  
Jonathan D. Tward ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Complete Response ◽  
Definitive Radiotherapy ◽  
High Incidence ◽  
Base Of The Tongue

OBJECTIVES: The study goal was to analyze the role of planned neck dissection for squamous cell carcinoma of the base of the tongue treated with definitive radiotherapy or chemoradiation. STUDY DESIGN, SETTING: We conducted a retrospective study of patients with squamous cell carcinoma of the base of the tongue undergoing planned neck dissection after definitive radiotherapy or chemoradiation. RESULTS: Twenty-two of 41 (53.7%) patients had one to six positive residual lymph nodes after receiving definitive radiotherapy or chemoradiation. Neck control rates were 92.3% and 88.3% at two and five years, respectively. Three of 22 (13.6%) patients with pathological residual nodal disease had regional or locore-gional failures, compared with 1 of 19 (5.3%) patients with a pathologically complete response ( P = 0.39). CONCLUSIONS: We observed a high incidence of pathologically residual lymph nodes after definitive radiotherapy or chemoradiation. SIGNIFICANCE: Planned neck dissection following definitive radiotherapy or chemoradiation is highly effective in achieving regional control of squamous cell carcinoma of the base of the tongue.

Sign in / Sign up

Export Citation Format

Share Document