scholarly journals Molecular identification and functional characterization of an adenylyl cyclase from the honeybee

2006 ◽  
Vol 96 (6) ◽  
pp. 1580-1590 ◽  
Author(s):  
Sebastian Wachten ◽  
Jana Schlenstedt ◽  
Renate Gauss ◽  
Arnd Baumann
Keyword(s):  
Adenylyl Cyclase ◽  
Molecular Identification ◽  
Functional Characterization

scholarly journals Functional Characterization of the Adenylyl Cyclase Genesgs-1by Analysis of a Mutational Spectrum inCaenorhabditis elegans

Genetics ◽  
2002 ◽  
Vol 161 (1) ◽  
pp. 133-142 ◽  
Author(s):  
Celine Moorman ◽  
Ronald H A Plasterk
Keyword(s):  
Life Span ◽  
Adenylyl Cyclase ◽  
Neuronal Degeneration ◽  
Functional Characterization ◽  
Adenylyl Cyclases ◽  
Loss Of Function ◽  
C Elegans ◽  
Larval Stages ◽  
Pharyngeal Pumping

AbstractThe sgs-1 (suppressor of activated Gαs) gene encodes one of the four adenylyl cyclases in the nematode C. elegans and is most similar to mammalian adenylyl cyclase type IX. We isolated a complete loss-of-function mutation in sgs-1 and found it to result in animals with retarded development that arrest in variable larval stages. sgs-1 mutant animals exhibit lethargic movement and pharyngeal pumping and (while not reaching adulthood) have a mean life span that is >50% extended compared to wild type. An extensive set of reduction-of-function mutations in sgs-1 was isolated in a screen for suppressors of a neuronal degeneration phenotype induced by the expression of a constitutively active version of the heterotrimeric Gαs subunit of C. elegans. Although most of these mutations change conserved residues within the catalytic domains of sgs-1, mutations in the less-conserved transmembrane domains are also found. The sgs-1 reduction-of-function mutants are viable and have reduced locomotion rates, but do not show defects in pharyngeal pumping or life span.

scholarly journals Molecular Identification and Functional Characterization of the Human Colonic Thiamine Pyrophosphate Transporter

2013 ◽  
Vol 289 (7) ◽  
pp. 4405-4416 ◽  
Author(s):  
Svetlana M. Nabokina ◽  
Katsuhisa Inoue ◽  
Veedamali S. Subramanian ◽  
Judith E. Valle ◽  
Hiroaki Yuasa ◽  
...  
Keyword(s):  
Molecular Identification ◽  
Functional Characterization ◽  
Thiamine Pyrophosphate

AmTAR2: Functional characterization of a honeybee tyramine receptor stimulating adenylyl cyclase activity

2017 ◽  
Vol 80 ◽  
pp. 91-100 ◽  
Author(s):  
Tina Reim ◽  
Sabine Balfanz ◽  
Arnd Baumann ◽  
Wolfgang Blenau ◽  
Markus Thamm ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Functional Characterization ◽  
Cyclase Activity ◽  
Adenylyl Cyclase Activity
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