scholarly journals The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats

2011 ◽  
Vol 162 (7) ◽  
pp. 1521-1533 ◽  
Author(s):  
L Huang ◽  
GG Mackenzie ◽  
N Ouyang ◽  
Y Sun ◽  
G Xie ◽  
...  
Keyword(s):  
The Novel ◽  
Adjuvant Induced Arthritis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Quinoline as TRPV1 Antagonists: A New Approach against Inflammation

2019 ◽  
Vol 9 (4-s) ◽  
pp. 782-788
Author(s):  
Megha P. Ambatkar ◽  
Pramod B. Khedekar
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
The Novel ◽  
Quinoline Ring ◽  
First Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Transient Receptor ◽  
Acute And Chronic Inflammation

Inflammation is the first response of the immune system to harmful stimuli such as infection or irritation, consists of a cascade of biochemical events that propagates and matures the inflammatory response. Number of anti-inflammatory drugs are available for treatment of acute and chronic inflammation. Many anti-inflammatory drugs cause adverse side effects. The quinoline class of compounds are important for searching the safe and effective anti-inflammatory drugs. These drugs are classified based on the number of substituents present on the quinoline ring or compounds containing a quinoline ring fused to other heterocyclic compounds. Quinolines have the ability to target several causes of inflammation includes transient receptor potential vanilloid 1 receptor. The TRPV1 receptor, first cloned and characterized in 1997, is a non-selective cation channel expressed in primary sensory neurons, and is a key pain sensor and integrator. This review provides the discovery of various quinoline derivatives as transient receptor potential vanilloid 1 (TRPV1) antagonists. Overall, the quinoline moiety will be used as a new template for designing and identifying the novel anti-inflammatory drugs in future. Keywords: Quinoline, Inflammation, Transient receptor Potential Vanilloid 1, Antagonists.

scholarly journals Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3421 ◽  
Author(s):  
Helfried Neumann ◽  
Alexey G. Sergeev ◽  
Anke Spannenberg ◽  
Matthias Beller
Keyword(s):  
The Novel ◽  
Heck Coupling ◽  
One Pot ◽  
Aryl Bromides ◽  
Palladium Catalyzed ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.

scholarly journals Effects of the novel anti‐inflammatory drugs robenacoxib and AHI‐805 on recovery of ischemic injured equine jejunum ex vivo

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
John Fraser Marshall ◽  
Adria Bhatnagar ◽  
Susan Bowman ◽  
Natalie Morris ◽  
Dinah Skorich ◽  
...  
Keyword(s):  
Ex Vivo ◽  
The Novel ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals CURRENT DEVELOPMENTS ON ANTI-INFLAMMATORY NATURAL MEDICINES

2018 ◽  
Vol 11 (8) ◽  
pp. 61 ◽  
Author(s):  
Sayanna Das ◽  
Sudip Kumar Mandal
Keyword(s):  
Natural Products ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Marine Sponges ◽  
The Novel ◽  
Plant Products ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Natural Medicines ◽  
Anti Inflammation

New anti-inflammatory substances are still vitally necessary due to intolerable side effects of the marketed anti-inflammatory drugs; however, the search for the novel entity against inflammation is challenging because of the complexity of the inflammatory process and its role in host defense to infections. Nature is the source of remedies for the mankind. Among the different biological activities of natural products that have been published till date, anti-inflammation is one of the most reported effects. In this review, we have discussed the current (2009–2018) information of some single natural products (quercetin, parthenolide, resveratrol, curcumin, cucurbitacin, capsicin, 1,8-cineole, bromelain, boswellic acid, lyprinol, and coumarin), plant products (garlic, ginger, papaya, blueberry, aloe, broccoli, olive, and rosemary), and non-plant products (marine sponges, mushrooms, and honey) having anti-inflammatory effects. Current information is mainly based on the molecular mechanisms of the above-mentioned products.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

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