Association of interferon regulatory factor -7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients

2008 ◽  
Vol 28 (6) ◽  
pp. 798-806 ◽  
Author(s):  
Radsamee Sermasathanasawadi ◽  
Naoya Kato ◽  
Ryosuke Muroyama ◽  
Narayan Dharel ◽  
Run-Xuan Shao ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Chronic Hepatitis C ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Interferon Regulatory Factor 7 ◽  
Chronic Hepatitis C Patients

scholarly journals Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Kessarin Thanapirom ◽  
Sirinporn Suksawatamnuay ◽  
Wattana Sukeepaisarnjaroen ◽  
Pisit Tangkijvanich ◽  
Sombat Treeprasertsuk ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Treatment Response ◽  
Chronic Hepatitis C ◽  
Pegylated Interferon ◽  
Related Gene ◽  
Chronic Hepatitis C Patients ◽  
Predict Treatment Response

scholarly journals Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hala Mosaad ◽  
Emad A. Emam ◽  
Emad F. Hamed ◽  
Ezzat A. El Demerdash ◽  
Samia Hussein
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Chronic Hepatitis C ◽  
Control Group ◽  
Vdr Gene ◽  
Group A ◽  
Chronic Hepatitis C Patients

Abstract Background Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide. Vitamin D receptor (VDR) gene polymorphisms were linked to different cancers. This study was carried out to assess the possible relation between VDR gene polymorphism and the occurrence of HCC in chronic hepatitis C patients. This study included 102 subjects classified into three groups. Group A included 34 healthy subjects as control. Group B included 34 chronic hepatitis C patients with HCC. Group C included 34 chronic hepatitis C patients without HCC. Estimation of Apa-1 VDR gene polymorphism was performed by restriction fragment length polymorphism-Polymerase chain reaction (RFLP-PCR). Results In HCC group, C allele was more frequent than A allele (80.88% and 19.12%), respectively. In chronic hepatitis group, C allele was more frequent than A allele (64.71% and 35.29%), respectively. In control group, A allele was more frequent than C allele (73.53% and 26.47%), respectively. Genotype CC + CA was dominant in HCC group (91.18%) and chronic hepatitis group (79.41%). In the control group, the dominant genotype was AA (58.82%). Moreover, there was a significant relation between Apa-1 VDR genotype CC and tumor size. Conclusions There is an association between VDR Apa-1 polymorphism and the occurrence of HCC in chronic hepatitis C patients.

scholarly journals Hemochromatosis Gene Polymorphism as a Predictor of Sustained Virological Response to Antiviral Treatment in Egyptian Chronic Hepatitis C Patients

2017 ◽  
Vol 7 (2) ◽  
pp. 154-157 ◽  
Author(s):  
Mai I Mehrez ◽  
Dina SA Fattah ◽  
Naglaa AA Azeem ◽  
Mohamed A Saleh ◽  
Khadiga M Mostafa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Sustained Virological Response ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Antiviral Treatment ◽  
C282y Mutation ◽  
Hemochromatosis Gene ◽  
Chronic Hepatitis C Patients

ABSTRACT Aim The aim of this article is to assess HFE C282Y gene mutations as a predictor of sustained virological response (SVR) to anti-hepatitis C virus (HCV) treatment in Egyptian patients. Materials and methods One hundred and forty chronic hepatitis C (CHC) patients were divided into two groups: 70 patients achieved SVR and 70 patients were nonresponders (NRs). All patients were subjected to quantitative polymerase chain reaction (PCR) at baseline, 12 and 24 weeks after therapy commencement. Deoxyribonucleic acid (DNA) sequencing for HFE (C282Y) was done by restriction fragment length polymorphism PCR. Results Sixty five patients did not have mutation and 5 patients had C282Y mutation (GA) with SVR. While 45 NRs had heterozygous C282Y mutation (GA), 4 patients (5.7%) had homozygous mutation (AA) and 21 patients (30%) had no mutation (GG). The parameters of elevated iron [transferrin saturation (TS; p < 0.001), S iron (p < 0.02), total iron binding capacity (TIBC; p < 0.001), transferrin (p < 0.016), and soluble transferrin receptor (sTfR; p-value, 0.001)] were significantly associated with C282Y mutation. However, there was no significant difference regarding ferritin values and C282Y mutation in NR patients. Conclusion Iron overload was frequently detected in CHC patients and associated with C282Y mutation, while biochemical markers of iron overload and C282Y HFE mutation were negative prognostic factor. How to cite this article Mehrez MI, Fattah DSA, Azeem NAA, Saleh MA, Mostafa KM. Hemochromatosis Gene Polymorphism as a Predictor of Sustained Virological Response to Antiviral Treatment in Egyptian Chronic Hepatitis C Patients. Euroasian J Hepato-Gastroenterol 2017;7(2):154-157.

Can NLRP3 gene polymorphism in Egyptian chronic hepatitis C patients affect the degree of liver fibrosis?

2015 ◽  
Vol 2 (3) ◽  
pp. 116-122
Author(s):  
Shady Z. K. Estfanous ◽  
◽  
Sameh M Seif ◽  
Sameh H. A. Soror ◽  
Dalia H. A. Abdelaziz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Gene Polymorphism ◽  
Chronic Hepatitis C ◽  
Nlrp3 Gene ◽  
Chronic Hepatitis C Patients

scholarly journals Insulin Resistance in Non Diabetic Chronic Hepatitis C patients

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Mohamed S. Zaghlol, Mohamed T. Al-Sayed Ahmed Qasem Mohamed,
Keyword(s):  
Insulin Resistance ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Insulin ◽  
Healthy Controls ◽  
Fasting Serum ◽  
Cirrhotic Patients ◽  
Chronic Hepatitis C Patients

Patients with chronic hepatitis have impaired glucose metabolism with hyperinsulinemia and insulin resistance, this hyperinsulinemia has been shown to be due to decreased insulin catabolism rather than increased pancreatic insulin secretion.We aim to evaluate insulin resistance in non diabetic patients with chronic hepatitis C virus infection. our study was a case-control study conducted in Tropical Medicine and Gastroenterology Department AL-Azhar University Hospital. 60 patients and 30 healthy controls were included in the study. The patients were classified into two groups:Group A: 30 patients with chronic hepatitis C infection were selected with positive HCV RNA in serum for at least 6 months; Patients were not receiving anti-viral therapy at the time of sampling They showed no evidence of cirrhosis. Group B: 30 patients with HCV related liver cirrhosis. They were divided according to Child Pugh score; twenty patients with HCV related compensated liver cirrhosis (Child A) Ten patients with HCV related decompensated liver cirrhosis (Child B and C). Group C: The control group: included 30 healthy individuals.  All patients and control were subjected to the following: Liver function tests: Alanine transaminase (ALT), Aspartate transaminase (AST), total and direct bilirubin, total protein, serum albumin. Prothrombin time (PT) & international normalization ratio (INR). Renal function tests: Blood urea nitrogen (BUN), Na, K. Complete blood count. Alpha fetoprotein (αFP).  Overnight fasting and two hours postprandial blood glucose level. Fasting serum insulin of each individual.  Insulin resistance was  determined via the Homeostasis  Model assessment (HOMA-IR) Statistical analysis of data will be done by using SPSS(statistical program for social science version22,produced by IBM SPSS Inc.,Chicago,USA). Results: We found that out of 30 CHC and 30 LC (20 compensated LC, 10 de compensated LC) 8 (26.7%); 8 (40%) patients and 5(50%) respectively had HOMA-IR levels greater than 2.5, which is consistent with IR diagnosis. Decompensated cirrhotic patients showed higher frequency of IR compared  to CHC, and compensated cirrhotic patients. Coclusion: In chronic hepatitis C patients, HOMA-IR, fasting serum insulin and fasting blood glucose were significantly higher than healthy controls.

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