Safety of Serial Monthly Administration of Triple-Dose Gadopentetate Dimeglumine in Multiple Sclerosis Patients: Preliminary Results of the BECOME Trial

2005 ◽  
Vol 15 (3) ◽  
pp. 289-290 ◽  
Author(s):  
Leo J. Wolansky ◽  
Mohammad H. Haghighi ◽  
Evangelia Sevdalis ◽  
Stuart D. Cook ◽  
Nilay Sethi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gadopentetate Dimeglumine ◽  
Preliminary Results ◽  
Monthly Administration ◽  
Multiple Sclerosis Patients ◽  
Triple Dose

scholarly journals Is the Concept of Quality of Life Relevant for Multiple Sclerosis Patients with Cognitive Impairment? Preliminary Results of a Cross-Sectional Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30627 ◽  
Author(s):  
Karine Baumstarck ◽  
Jean Pelletier ◽  
Valérie Aghababian ◽  
Françoise Reuter ◽  
Irina Klemina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Preliminary Results ◽  
Multiple Sclerosis Patients

scholarly journals Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients

2016 ◽  
Vol 23 (7) ◽  
pp. 963-972 ◽  
Author(s):  
Ludwig Schlemm ◽  
Claudia Chien ◽  
Judith Bellmann-Strobl ◽  
Jan Dörr ◽  
Jens Wuerfel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Dentate Nucleus ◽  
Alternative Explanation ◽  
Disease Duration ◽  
Gadopentetate Dimeglumine ◽  
Progressive Neurodegeneration ◽  
Magnetic Resonance Imaging Mri ◽  
T1 Hyperintensity ◽  
Multiple Sclerosis Patients

Background: Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs). Objective: To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is associated with GBCA administration. Methods: In a cohort of 97 MS patients, the dentate-to-pons signal intensity ratio (DPSIR) was calculated for 265 consecutive T1-weighted magnetic resonance (MR) scans (including sessions with and without the administration of GBCA). Patients exclusively received either gadopentetate dimeglumine (Gd-DTPA, linear) or gadobutrol (Gd-BT-DO3A, macrocyclic). Results: In patients receiving Gd-DTPA, DPSIR increased significantly between the first and the last scan (+0.009, p < 0.001), and following magnetic resonance imaging (MRI) with Gd-DTPA administration as compared to following an MRI without Gd-DTPA administration (+0.005 vs −0.001; p = 0.022). Additionally, there was a positive linear relationship between the number of Gd-DTPA administrations and the increase in DPSIR ( p = 0.017). No DPSIR increase was observed after Gd-BT-DO3A administration. Conclusion: Dentate nucleus T1 hyperintensity in MS patients is associated with Gd-DTPA (but not Gd-BT-DO3A) administration, suggesting an alternative explanation for the association of T1 hyperintensity with disease duration and severity.

scholarly journals Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry

2016 ◽  
Vol Volume 10 ◽  
pp. 1647-1656 ◽  
Author(s):  
Waldemar Brola ◽  
Piotr Sobolewski ◽  
Małgorzata Fudala ◽  
Stanisław Flaga ◽  
Konrad Jantarski ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Preliminary Results ◽  
Multiple Sclerosis Patients

Triple-Dose Versus Single-Dose Gadoteridol in Multiple Sclerosis Patients

1994 ◽  
Vol 4 (3) ◽  
pp. 141-145 ◽  
Author(s):  
Leo J. Wolansky ◽  
John A. Bardini ◽  
Stuart D. Cook ◽  
Alan E. Zimmer ◽  
Amiram Sheffet ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Dose ◽  
Multiple Sclerosis Patients ◽  
Triple Dose
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