Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries

Apmis ◽  
2011 ◽  
Vol 119 (8) ◽  
pp. 487-497 ◽  
Author(s):  
LASSE VINNER ◽  
BIRGITTA HOLMGREN ◽  
KRISTOFFER J. JENSEN ◽  
JOAKIM ESBJORNSSON ◽  
Marie BORGGREN ◽  
...  
2020 ◽  
Author(s):  
Roseline Affi ◽  
Delphine Gabillard ◽  
Catherine Dunyach-Remy ◽  
Jean-Baptiste Ntakpe ◽  
Raoul Moh ◽  
...  
Keyword(s):  

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3821
Author(s):  
Rita Meleddu ◽  
Angela Corona ◽  
Simona Distinto ◽  
Filippo Cottiglia ◽  
Serenella Deplano ◽  
...  

Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for the use of lower doses of each single agent to reduce toxicity. However, avoiding drugs interactions and patient compliance are issues not fully accomplished so far. Pursuing on our investigation on potential anti HIV multi-target agents we have designed and synthesized a small library of biphenylhydrazo 4-arylthiazoles derivatives and evaluated to investigate the ability of the new derivatives to simultaneously inhibit both associated functions of HIV reverse transcriptase. All compounds were active towards the two functions, although at different concentrations. The substitution pattern on the biphenyl moiety appears relevant to determine the activity. In particular, compound 2-{3-[(2-{4-[4-(hydroxynitroso)phenyl]-1,3-thiazol-2-yl} hydrazin-1-ylidene) methyl]-4-methoxyphenyl} benzamide bromide (EMAC2063) was the most potent towards RNaseH (IC50 = 4.5 mM)- and RDDP (IC50 = 8.0 mM) HIV RT-associated functions.


2021 ◽  
Vol 9 (7) ◽  
pp. 1346
Author(s):  
Mariana Petkova ◽  
Petya Stefanova ◽  
Velitchka Gotcheva ◽  
Angel Angelov

Traditional sourdoughs in Bulgaria were almost extinct during the centralized food production system. However, a rapidly developing trend of sourdough revival in the country is setting the demand for increased production and use of commercial starter cultures. The selection of strains for such cultures is based on geographical specificity and beneficial technological properties. In this connection, the aim of this study was to isolate, identify and characterize lactic acid bacteria (LAB) and yeasts from typical Bulgarian sourdoughs for the selection of strains for commercial sourdough starter cultures. Twelve samples of typical Bulgarian sourdoughs were collected from different geographical locations. All samples were analyzed for pH, total titratable acidity and dry matter content. Enumeration of LAB and yeast was also carried out. Molecular identification by 16S rDNA sequence analysis was performed for 167 LAB isolates, and 106 yeast strains were identified by ITS1-5.8S-ITS2 rRNA gene partial sequence analysis. The LAB strains were characterized according to their amylolytic and proteolytic activity and acidification capacity, and 11 strains were selected for further testing of their antimicrobial properties. The strains with the most pronounced antibacterial and antifungal activity are listed as recommended candidates for the development of starter cultures for sourdoughs or other food products.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
U Laaser ◽  
V Bjegovic-Mikanovic

Abstract Background To reach the targets of SDG3 not more than a decade is left. How do the Low and Middle-Income Countries in Northern Africa - in the immediate neighborhood to Europe - compare to the 15 members of the Economic Community of West African States (ECOWAS), and well-developed European countries around the Baltic Sea (the “Northern Dimension”) incl. Russia? Methods We used quantifiable mortality indicators and targeted reductions until 2030, as published for SDG3.1/2/3 by the United Nations in 2015. To estimate progress or delay we used the methodology of the United Nations Development Program (UNDP) based on the target year 2030, a year of observation, and a year at baseline. For the comparison between Northern Africa/Northern Europe we calculated for indicator 3.3 the Premature Years of Life Lost (PYLL) and for the comparison of Northern/Western Africa the more sensitive indicators 3.1 and 2, the Maternal Mortality Ratio (MMR), the Neonatal Mortality Rate NMR, and the under-five Mortality Rate (<5MR). Results In Northern Africa, only Algerian and Morocco will achieve the 2030 target 3.4 in time i.e., 2.5 and 7 years in advance, whereas Egypt, Libya and Tunisia are in delay Mauretania even by 14.5 years. The countries around the Baltic Sea likely will achieve the targeted reduction before 2030, Estonia on top already 2025, followed by Latvia and Finland in 2026, and the Russian Federation in 2027. Among the 15 West African states, Capo Verde has reached the targets 3.1 and 2 already, followed by Senegal (e.g., 4.0 years in advance for <5MR) and Ghana, whereas Guinea Bissau is positioned at the end with a delay of 4,2 years for MMR. The countries of Northern Africa are on track except for Algeria, with 6.2 years in delay for MMR and Mauretania for all indicators. Conclusions Whereas the European countries are well in advance of the SDG targets, Northern Africa shows a mixed picture and the countries of Western Africa with a few exceptions are in delay. Key messages European countries around the Baltic Sea and Russia are well on track for SDG3, reducing their premature mortality by one third until 2030. Whereas the European countries are well in advance of the SDG targets, Northern Africa shows a mixed picture and the countries of Western Africa with a few exceptions are in delay.


2007 ◽  
Vol 23 (9) ◽  
pp. 1131-1138 ◽  
Author(s):  
Fabio Tramuto ◽  
Filippa Bonura ◽  
Anna Maria Perna ◽  
Salvatrice Mancuso ◽  
Alberto Firenze ◽  
...  

2009 ◽  
Vol 200 (8) ◽  
pp. 1202-1206 ◽  
Author(s):  
Cédric F. Invernizzi ◽  
Dimitrios Coutsinos ◽  
Maureen Oliveira ◽  
Daniela Moisi ◽  
Bluma G. Brenner ◽  
...  

2007 ◽  
Vol 34 (2) ◽  
pp. 77 ◽  
Author(s):  
Erik Klop ◽  
Janneke van Goethem ◽  
Hans H. de Iongh

The preference of grazing herbivores to feed on grass regrowth following savanna fires rather than on unburnt grass swards is widely recognised. However, there is little information on which factors govern patterns of resource selection within burnt areas. In this study, we attempted to disentangle the effects of different habitat and grass sward characteristics on the utilisation of post-fire regrowth by nine species of ungulates in a fire-dominated woodland savanna in north Cameroon. We used resource-selection functions based on logistic regression. Overall, the resource-selection functions identified the time elapsed since burning as the most influential parameter in determining probability of use by ungulates, as most species strongly selected swards that were recently burned. This pattern might be related to nutrient levels in the grass sward. In addition, most species selected areas with high grass cover and avoided grass swards with high amounts of dead stem material. This is likely to increase bite mass and, hence, intake rates. The avoidance of high tree cover by some species may suggest selection for open areas with good visibility and, hence, reduced risk of predation. Body mass seemed to have no effect on differential selection of post-fire regrowth, irrespective of feeding style.


2011 ◽  
Vol 7 (2) ◽  
pp. e1001273 ◽  
Author(s):  
Guido Ferrari ◽  
Bette Korber ◽  
Nilu Goonetilleke ◽  
Michael K. P. Liu ◽  
Emma L. Turnbull ◽  
...  

2011 ◽  
Vol 13 (8-9) ◽  
pp. 766-770 ◽  
Author(s):  
Takuya Naruto ◽  
Hayato Murakoshi ◽  
Takayuki Chikata ◽  
Madoka Koyanagi ◽  
Yuka Kawashima ◽  
...  
Keyword(s):  
Hiv 1 ◽  

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