Inhibitory effect of azelastine, a potent antiallergic agent, on release of tumor necrosis factor-alpha from activated human peripheral blood mononuclear cells and U937 cells

1993 ◽  
Vol 2 (5) ◽  
pp. 231-235 ◽  
Author(s):  
Yoshiaki Hamamoto ◽  
Kou Nagai ◽  
Masahiko Muto ◽  
Chidori Asagami
Keyword(s):  
Tumor Necrosis ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Inhibitory Effect ◽  
U937 Cells ◽  
Peripheral Blood Mononuclear ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Antiallergic Agent

scholarly journals The Treponema denticola Surface Protease Dentilisin Degrades Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor Alpha

2006 ◽  
Vol 74 (4) ◽  
pp. 2462-2467 ◽  
Author(s):  
Meguru Miyamoto ◽  
Kazuyuki Ishihara ◽  
Katsuji Okuda
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Mononuclear Cells ◽  
Interleukin 1Β ◽  
Treponema Denticola ◽  
Peripheral Blood Mononuclear ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

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