The impact of tramadol and dihydrocodeine treatment on quality of life of patients with cancer pain

Abstract Purpose The main aim of the study was to assess the impact of individualized management of breakthrough cancer pain (BTcP) on quality of life (QoL) of patients with advanced cancer in clinical practice. Methods A prospective, observational, multicenter study was conducted in patients with advanced cancer that were assisted by palliative care units. QoL was assessed with the EORTC QLQ-C30 questionnaire at baseline (V0) and after 28 days (V28) of individualized BTcP therapy. Data on background pain, BTcP, comorbidities, and frailty were also recorded. Results Ninety-three patients completed the study. Intensity, duration, and number of BTcP episodes were reduced (p < 0.001) at V28 with individualized therapy. Transmucosal fentanyl was used in 93.8% of patients, mainly by sublingual route. Fentanyl titration was initiated at low doses (78.3% of patients received doses of 67 μg, 100 μg, or 133 μg) according to physician evaluation. At V28, mean perception of global health status had increased from 31.1 to 53.1 (p < 0.001). All scales of EORTC QLQ-C30 significantly improved (p < 0.001) except physical functioning, diarrhea, and financial difficulties. Pain scale improved from 73.6 ± 22.6 to 35.7 ± 22.3 (p < 0.001). Moreover, 85.9% of patients reported pain improvement. Probability of no ≥ 25% improvement in QoL was significantly higher in patients ≥ 65 years old (OR 1.39; 95% CI 1.001–1.079) and patients hospitalized at baseline (OR 4.126; 95% CI 1.227–13.873). Conclusion Individualized BTcP therapy improved QoL of patients with advanced cancer. Transmucosal fentanyl at low doses was the most used drug. Trial registration This study was registered at ClinicalTrials.gov database (NCT02840500) on July 19, 2016.

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Effects of Massage on Pain Intensity, Analgesics and Quality of Life in Patients with Cancer Pain: A Pilot Study of a Randomized Clinical Trial Conducted Within Hospice Care Delivery

The Hospice Journal ◽

10.1080/0742-969x.2000.11882956 ◽

2000 ◽

Vol 15 (3) ◽

pp. 31-53 ◽

Cited By ~ 1

Author(s):

Diana J. Wilkie ◽

Janice Kampbell ◽

Susan Cutshall ◽

Heather Halabisky ◽

Hilda Harmon ◽

...

Keyword(s):

Quality Of Life ◽

Clinical Trial ◽

Pilot Study ◽

Cancer Pain ◽

Pain Intensity ◽

Randomized Clinical Trial ◽

Hospice Care ◽

Care Delivery ◽

Patients With Cancer

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Music therapy effectiveness by duration in patients with cancer: a meta-regression

BMJ Supportive & Palliative Care ◽

10.1136/bmjspcare-2021-003163 ◽

2021 ◽

pp. bmjspcare-2021-003163

Author(s):

Ronald Chow ◽

Robert Bergner ◽

Elizabeth Prsic

Keyword(s):

Quality Of Life ◽

Music Therapy ◽

Positive Association ◽

Well Being ◽

Patients With Cancer ◽

Therapy Effectiveness ◽

Meta Regression ◽

Meta Analyses ◽

The Impact

ObjectivesSeveral reviews and meta-analyses have reported on music therapy for physical and emotional well-being among patients with cancer. However, the duration of music therapy offered may range from less than 1 hour to several hours. The aim of this study is to assess whether longer duration of music therapy is associated with different levels of improvement in physical and mental well-being.MethodsTen studies were included in this paper, reporting on the endpoints of quality of life and pain. A meta-regression, using an inverse-variance model, was performed to assess the impact of total music therapy time. A sensitivity analysis was conducted for the outcome of pain, among low risk of bias trials.ResultsOur meta-regression found a trend for positive association between greater total music therapy time and improved better pain control, but it was not statistically significant.ConclusionThere is a need for more high-quality studies examining music therapy for patients with cancer, with a focus on total music therapy time and patient-related outcomes including quality of life and pain.

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Pain management

Oxford Textbook of Medicine ◽

10.1093/med/9780198746690.003.0064 ◽

2020 ◽

pp. 629-633

Author(s):

Marie Fallon

Keyword(s):

Quality Of Life ◽

Pain Management ◽

Pain Relief ◽

Adverse Effects ◽

Cancer Pain ◽

Daily Functioning ◽

Opioid Analgesia ◽

Patients With Cancer ◽

Good Pain Relief

Pain occurs in more than 50% of patients with advanced disease, interferes with daily functioning and quality of life, and is very often undertreated. Patients can find it difficult to articulate the character of their pains, but it is important to determine whether it is somatic, neuropathic, or visceral since this has important implications for management. For most patients with cancer pain, a three-step approach combining simple or opioid analgesia (depending on severity) along with an adjuvant analgesic (depending on cause) will result in good pain relief, but the challenge is to achieve good pain relief without unacceptable adverse effects.

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The Impact of a Primary Care, Pharmacist-Driven Intervention in Patients with Chronic Non-Cancer Pain—A Pilot Study

Pharmacy ◽

10.3390/pharmacy8030113 ◽

2020 ◽

Vol 8 (3) ◽

pp. 113

Author(s):

Mo Chen ◽

Tejal Patel ◽

Feng Chang

Keyword(s):

Quality Of Life ◽

Primary Care ◽

Chronic Pain ◽

Cancer Pain ◽

Family Health ◽

Primary Care Settings ◽

Pain Intervention ◽

Family Health Team ◽

The Impact

Background: Chronic pain is a prevalent condition, experienced by 15.3% to 55% of Canadians, that is difficult to manage. With their broad accessibility and expertise on drugs, primary care pharmacists can help patients optimize their pain management. Methods: The objective of this study is to examine the effectiveness of a primary care, pharmacist-driven chronic pain intervention on pain and quality of life in patients with chronic non-cancer pain. A three-month naturalistic prospective study was conducted in primary care settings (five community pharmacies and one Family Health Team) across Ontario, Canada with a total of six pharmacists and 19 study participants. The primary care, pharmacist-driven chronic pain intervention consisted of patient assessments, medication reviews, care plan recommendations, and patient education. In order to evaluate the effectiveness of the intervention, pain intensity, pain interference, and quality of life were evaluated at baseline and at follow up (week 2 and month 3). Results: Trends towards improvement in pain and quality of life were found, however, these improvements were not statistically significant at follow up (month 3). Conclusions: This study provides the foundational research required to better understand the impact of Ontario pharmacists’ extended role in pain management in non-cancer patients within multiple primary care settings (e.g., Family Health Team, etc.) and has illustrated the importance of modifying and customizing care plans in patients with chronic pain. A larger sample size with tailored outcome measures may be necessary to better highlight significant improvements in pain and quality of life in patients with chronic non-cancer pain using a primary care, pharmacist-driven intervention.

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Application of quality control circle in the treatment of moderate cancer pain in inpatients

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyz214 ◽

2020 ◽

Vol 50 (5) ◽

pp. 581-585

Author(s):

Yehuan Liu ◽

Beibei Lin

Keyword(s):

Quality Of Life ◽

Quality Control ◽

Cancer Pain ◽

Pain Control ◽

Management Tool ◽

Control Group ◽

Observation Group ◽

Patients With Cancer ◽

Significant Difference

Abstract Context Pain is one of the most common and intolerable symptoms in cancer patients. But cancer pain control is still negative in China. Objectives This paper explores the application of quality control circle in the treatment of cancer pain in inpatients to improve the quality of life of patients with cancer pain. Method Established a quality control circle group to analyze the current status of cancer pain control in inpatients with moderate cancer pain, set goals, formulate corresponding countermeasures and implement and review them in stages. The plan-do-check-act method was cyclically applied. The Brief Pain Inventory was used to evaluate the cancer pain status of patients with cancer pain hospitalized before (January to April 2016) and after (September to December 2016) the implementation of quality control circle activities. Results The pain control effect of the observation group was significantly better than that of the control group. The mean (standard deviation) of pain severity and pain interference in the observation group were significantly lower than those in the control group (6.21 [2.86] vs 4.31 [2.25], 10.54 [4.10] vs 7.25 [3.77]). There was significant difference after the implementation of quality control circle (P < 0.01). Conclusion Quality control circle activities are used to manage patients with cancer pain, to improve the situation of pain control and to improve the quality of life of patients. This management tool and method is worthy of clinical promotion and application.

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Evaluating the Impact of Provincial Implementation of Screening for Distress on Quality of Life, Symptom Reports, and Psychosocial Well-Being in Patients With Cancer

Journal of the National Comprehensive Cancer Network ◽

10.6004/jnccn.2016.0019 ◽

2016 ◽

Vol 14 (2) ◽

pp. 164-172 ◽

Cited By ~ 16

Author(s):

Linda Watson ◽

Shannon Groff ◽

Rie Tamagawa ◽

Jennifer Looyis ◽

Sydney Farkas ◽

...

Keyword(s):

Quality Of Life ◽

Well Being ◽

Patients With Cancer ◽

Symptom Reports ◽

Screening For Distress ◽

The Impact

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The impact of informing diagnosis on quality of life in patients with cancer: A systematic review and meta-analysis

10.21203/rs.3.rs-16112/v2 ◽

2020 ◽

Author(s):

Miao Wan ◽

Xianggui Luo ◽

Louis.B NDZANA MVOGO ◽

Juan Wang ◽

Chen Chang ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Meta Analysis ◽

Cognitive Activity ◽

Biomedical Literature ◽

Cochrane Central Register ◽

Patients With Cancer ◽

General Quality ◽

The Impact

Abstract Objective To assess the impact of informing diagnosis and disease status on the quality of life in patients with cancer Method We searched the follow databases, Pubmed, CENTRAL(Cochrane Central Register of Controlled Trials), PsycINFO, WEB OF SCIENCE, Embase, CBM (Chinese Biomedical Literature database), WANFANG database (Chinese Medicine Premier), and CNKI (China National Knowledge Infrastructure). And the terms used are as follows: neoplasm, cancer, tumour, tumor, carcinoma, disclosure, truth telling, breaking bad news, knowledge, knowing, awareness, quality of life, QOL. Pairs of reviewers independently screened documents and extracted the data. Meta-analysis was conducted by Revman 5.0 software. Results There were 11740 records retrieved from databases and 23 studies were included finally. Meta-analysis of informed and uniformed cancer patients revealed no differences in both the general quality of life and symptoms of fatigue, pain, dyspnea, insomnia, appetite loss and diarrhea (P>0.05). Additionally, no difference in physical function, role function, cognitive activity and emotional function between the above 2 groups(P>0.05) were found. On the vitality area, the patients who were totally informed about their diagnosis had higher vitality than the uniformed patients. However, patients aware about their illnesses seemed to get lower scores in social function. Between the partly informed of the diagnosis and uninformed cancer patients, there were no differences in general quality of life, function domains and disease-related symptoms (P>0.05). Conclusion Informing the cancer patients their diagnosis may not have a bad effect on their quality of life. PROSPERO registration number CRD42017060073.

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