Protective Role of Perillic Acid Against Radiation−Induced Oxidative Stress, Cytokine Profile, DNA Damage, and Intestinal Toxicity in Mice

2010 ◽  
Vol 29 (3) ◽  
pp. 199-212 ◽  
Author(s):  
P. Pratheeshkumar ◽  
T.J. Raphael ◽  
Girija Kuttan
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Protective Role ◽  
Cytokine Profile ◽  
Intestinal Toxicity ◽  
Radiation Induced

Protective role of chrysin on doxorubicin‐induced oxidative stress and DNA damage in rat testes

Andrologia ◽  
2020 ◽  
Vol 52 (9) ◽  
Author(s):  
Saadet Belhan ◽  
Mustafa Özkaraca ◽  
Uğur Özdek ◽  
Ahmet Ufuk Kömüroğlu
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Protective Role

scholarly journals Oxidative Stress-Induced DNA Damage and Repair in Human Peripheral Blood Mononuclear Cells: Protective Role of Hemoglobin

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68341 ◽  
Author(s):  
Anat Gafter-Gvili ◽  
Boris Zingerman ◽  
Benaya Rozen-Zvi ◽  
Yaacov Ori ◽  
Hefziba Green ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Peripheral Blood Mononuclear Cells ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Protective Role ◽  
Peripheral Blood Mononuclear ◽  
Dna Damage And Repair ◽  
Blood Mononuclear Cells

Protective role of quercetin against copper(II)-induced oxidative stress: A spectroscopic, theoretical and DNA damage study

2017 ◽  
Vol 110 ◽  
pp. 340-350 ◽  
Author(s):  
Klaudia Jomova ◽  
Michael Lawson ◽  
Lenka Drostinova ◽  
Peter Lauro ◽  
Patrik Poprac ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Protective Role ◽  
Damage Study

scholarly journals Protective role of hesperidin against γ-radiation-induced oxidative stress and apoptosis in rat testis

2017 ◽  
Vol 24 (1) ◽  
Author(s):  
Nadia Z. Shaban ◽  
Ahmed M. Ahmed Zahran ◽  
Fatma H. El-Rashidy ◽  
Ahmad S. Abdo Kodous
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Γ Radiation ◽  
Rat Testis ◽  
Radiation Induced

scholarly journals Protective Role of Glutathione in the Hippocampus after Brain Ischemia

2021 ◽  
Vol 22 (15) ◽  
pp. 7765
Author(s):  
Youichirou Higashi ◽  
Takaaki Aratake ◽  
Takahiro Shimizu ◽  
Shogo Shimizu ◽  
Motoaki Saito
Keyword(s):  
Oxidative Stress ◽  
Neuronal Death ◽  
Excitatory Amino Acid ◽  
Ischemia Reperfusion ◽  
Thiol Group ◽  
Protective Role ◽  
Key Factor ◽  
Rate Limiting ◽  
Cysteine Uptake

Stroke is a major cause of death worldwide, leading to serious disability. Post-ischemic injury, especially in the cerebral ischemia-prone hippocampus, is a serious problem, as it contributes to vascular dementia. Many studies have shown that in the hippocampus, ischemia/reperfusion induces neuronal death through oxidative stress and neuronal zinc (Zn2+) dyshomeostasis. Glutathione (GSH) plays an important role in protecting neurons against oxidative stress as a major intracellular antioxidant. In addition, the thiol group of GSH can function as a principal Zn2+ chelator for the maintenance of Zn2+ homeostasis in neurons. These lines of evidence suggest that neuronal GSH levels could be a key factor in post-stroke neuronal survival. In neurons, excitatory amino acid carrier 1 (EAAC1) is involved in the influx of cysteine, and intracellular cysteine is the rate-limiting substrate for the synthesis of GSH. Recently, several studies have indicated that cysteine uptake through EAAC1 suppresses ischemia-induced neuronal death via the promotion of hippocampal GSH synthesis in ischemic animal models. In this article, we aimed to review and describe the role of GSH in hippocampal neuroprotection after ischemia/reperfusion, focusing on EAAC1.

Protective role of vitamin D against oxidative stress in diabetic retinopathy

2021 ◽  
Author(s):  
Maria Stella Valle ◽  
Cristina Russo ◽  
Lucia Malaguarnera
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Diabetic Retinopathy ◽  
Protective Role

scholarly journals Protective Role of Natural and Semi-Synthetic Tocopherols on TNFα-Induced ROS Production and ICAM-1 and Cl-2 Expression in HT29 Intestinal Epithelial Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 160
Author(s):  
Vladana Domazetovic ◽  
Irene Falsetti ◽  
Caterina Viglianisi ◽  
Kristian Vasa ◽  
Cinzia Aurilia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Properties ◽  
Intestinal Barrier ◽  
Protective Role ◽  
Intercellular Adhesion Molecule ◽  
Intestinal Epithelial ◽  
Intercellular Adhesion Molecule 1 ◽  
Beneficial Effects ◽  
Bowel Diseases

Vitamin E, a fat-soluble compound, possesses both antioxidant and non-antioxidant properties. In this study we evaluated, in intestinal HT29 cells, the role of natural tocopherols, α-Toc and δ-Toc, and two semi-synthetic derivatives, namely bis-δ-Toc sulfide (δ-Toc)2S and bis-δ-Toc disulfide (δ-Toc)2S2, on TNFα-induced oxidative stress, and intercellular adhesion molecule-1 (ICAM-1) and claudin-2 (Cl-2) expression. The role of tocopherols was compared to that of N-acetylcysteine (NAC), an antioxidant precursor of glutathione synthesis. The results show that all tocopherol containing derivatives used, prevented TNFα-induced oxidative stress and the increase of ICAM-1 and Cl-2 expression, and that (δ-Toc)2S and (δ-Toc)2S2 are more effective than δ-Toc and α-Toc. The beneficial effects demonstrated were due to tocopherol antioxidant properties, but suppression of TNFα-induced Cl-2 expression seems not only to be related with antioxidant ability. Indeed, while ICAM-1 expression is strongly related to the intracellular redox state, Cl-2 expression is TNFα-up-regulated by both redox and non-redox dependent mechanisms. Since ICAM-1 and Cl-2 increase intestinal bowel diseases, and cause excessive recruitment of immune cells and alteration of the intestinal barrier, natural and, above all, semi-synthetic tocopherols may have a potential role as a therapeutic support against intestinal chronic inflammation, in which TNFα represents an important proinflammatory mediator.

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