scholarly journals Neuroaxonal Regeneration is More Pronounced in Early Multiple Sclerosis than in Traumatic Brain Injury Lesions

2012 ◽  
Vol 23 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Lucas Schirmer ◽  
Doron Merkler ◽  
Fatima B. König ◽  
Wolfgang Brück ◽  
Christine Stadelmann
CNS Spectrums ◽  
2006 ◽  
Vol 11 (S6) ◽  
pp. 1-11 ◽  
Author(s):  
Jeffrey L. Cummings ◽  
David B. Arciniegas ◽  
Benjamin R. Brooks ◽  
Robert M. Herndon ◽  
Edward C. Lauterbach ◽  
...  

AbstractUncontrollable episodes of emotional expression occur in a variety of neurological conditions. This emotional disinhibition syndrome is characterized by episodes of crying or laughing that are unrelated to or out of proportion to the eliciting stimulus. This syndrome is common among patients with amyotrophic lateral sclerosis, multiple sclerosis, stroke, and traumatic brain injury and a variety of terms and definitions have been used to describe it. The confusing nomenclature has been a barrier to understanding, diagnosis, and treatment of this disorder. The authors propose a unifying term, involuntary emotional expression disorder (IEED), and provide diagnostic criteria for this disorder.


2011 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Farshid Amirabdollahian ◽  
Garth Johnson

Haptic and robotic technologies have the potential to provide assessment during interaction with humans. This manuscript presents our earlier research during the I-Match project where a haptic peg-in-hole test was used in order to compare between healthy volunteers' performance and those with neurological impairment. Subjects all performed a series of haptic virtual peg-in-hole tasks with varying degrees of difficulty determined by the hole diameter. Haptic instrument, Phantom Desktop 1.5, allowed for recording of biomechanical data which is used to present some variant features between the two subject groups. This paper analyses the placement time, maximum peg transfer velocity, collision forces recorded during peg placement and also insertion accuracy. The first three parameters showed statistically significant differences between the two groups while the last, insertion accuracy, showed insignificant differences (p= 0.152). This is thought to be due to the large clearance value between the smallest hole diameter and the peg. To identify differences between the haptic peg-in-hole and the established NHPT, we are currently in process of conducting a further experiment with a haptic replica of the NHPT test, in order to investigate effects resulting from addition of haptic force feedback compared to the original NHPT test, as well as allowing to explore influences caused by the 1 mm clearance value as originally proposed by Wade.Furthermore, in order to investigate if this method can identify differences between subjects with different neurological conditions, a larger group of subjects with neurological conditions such as stroke, multiple sclerosis, and traumatic brain injury is required to explore potency of this approach for identifying differences between these different conditions.


2021 ◽  
pp. 1-27
Author(s):  
Sarah J. Wallace ◽  
Janaki Kothari ◽  
Anushki Jayasekera ◽  
Jessica Tointon ◽  
Toluwalase Baiyewun ◽  
...  

Abstract Background and Objectives: This systematic review aimed to identify and appraise the evidence for online peer-support interventions for caregivers of stroke survivors (with and without aphasia), and people with dementia, traumatic brain injury (TBI), Parkinson’s disease and multiple sclerosis. Research Design and Methods: Systematic review conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Five databases were systematically searched up until September 2020: EMBASE, PubMed, CINAHL, Scopus and Web of Science. Two reviewers independently screened titles, abstracts and full-text articles. The methodological quality of included studies was assessed using Physiotherapy Evidence Database (PEDro) and Mixed-Methods Appraisal Tool (MMAT) scales. Interventions were described using the Template for Intervention Description and Replication (TIDieR) checklist. Results: A total of 3026 records were identified from database searches. Following screening, 18 studies reporting 17 interventions were included in this review. Most studies (n = 13) reported interventions for caregivers of people with dementia. All studies incorporated an element of peer support as part of the intervention, however, most interventions (n = 15) comprised both psychosocial and educational elements. Statistically significant changes were reported for 11 interventions in one or more of the following domains: caregiver knowledge, mental health, stress, depression, distress, burden, self-efficacy, mastery, helplessness and perceived support. Qualitative outcomes included perceived reductions in stress and increased emotional and informational support. Discussion and Implications: Positive changes in caregiver outcomes were identified in response to multi-component online interventions (i.e., peer support in addition to education). Peer support was often poorly described, limiting the conclusions that could be drawn about the intervention components which result in better outcomes. Online interventions may provide an accessible and effective means of supporting caregivers.


2019 ◽  
Vol 33 (11) ◽  
pp. 1775-1787
Author(s):  
Samuel Turcotte ◽  
Maude Beaudoin ◽  
Catherine Vallée ◽  
Claude Vincent ◽  
François Routhier

Objectives:This systematic review documents the content and the quality of the psychometric evidence concerning the utilization of the Community Integration Questionnaire for individuals living with a disability other than a traumatic brain injury.Data sources:Medline, Embase, CINAHL, OTseeker and PsycINFO (searched from inception to June 2019).Review methods:Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used for conducting and reporting this review. Studies that investigated at least one psychometric property of the Community Integration Questionnaire for individuals living with a disability other than traumatic brain injury were included. Data extraction and critical methodological appraisal of the articles (MacDermid checklist, COnsensus-based Standards for the selection of health Measurement INstruments checklist) were independently performed and validated by the first two authors.Results:Ten studies representing 3000 individuals met the inclusion criteria. Five populations were documented. There are positive and trustable data regarding internal consistency for adults living with multiple sclerosis, spinal cord injury or burns and in mixed samples ( α = 0.71–0.84). Construct validity is fairly documented for adults living with multiple sclerosis or aphasia and in mixed samples. Test–retest reliably is acceptable for adults living with multiple sclerosis (intraclass correlation coefficient = 0.91–0.97) as well as responsiveness (area under the receiver operating characteristic curve = 0.81). Other psychometric properties could not be demonstrated sufficiently solid.Conclusion:Many psychometric properties of the Community Integration Questionnaire are still poorly evaluated for adults living with a disability other than a traumatic brain injury. However, promising data have been documented in each population included in this review.


2021 ◽  
Vol 1 (8) ◽  
Author(s):  
Sara D. Khangura

CADTH’s Horizon Scanning Service identifies new and emerging technologies that may be of interest to health care decision-makers in Canada Health Technology Update articles generally focus on a single technology or intervention. This Horizon Scan presents a brief summary of information relevant to the Portable Neuromodulation Stimulator, designed to be used in conjunction with physical therapy to improve balance or gait impairments associated with mild-to-moderate symptoms of multiple sclerosis or mild-to-moderate traumatic brain injury.


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