pH-Dependent Chalcogenopyrylium Dyes as Potential Sensitizers for Photodynamic Therapy: Selective Retention in Tumors by Exploiting pH Differences between Tumor and Normal Tissue

1999 ◽  
Vol 70 (4) ◽  
pp. 630-636 ◽  
Author(s):  
David A. Bellnier ◽  
David N. Young ◽  
Michael R. Detty ◽  
Susan H. Camacho ◽  
Allan R. Oseroff
Keyword(s):  
Photodynamic Therapy ◽  
Normal Tissue ◽  
Chalcogenopyrylium Dyes ◽  
Selective Retention ◽  
Ph Dependent

APPLICATION OF PIXE TO CANCER RESEARCH

1992 ◽  
Vol 02 (04) ◽  
pp. 529-534 ◽  
Author(s):  
HUIYING YAO ◽  
XIANZHOU ZENG ◽  
JIYAO CHEN ◽  
WEN CHEN ◽  
HUAIXIN CAI ◽  
...  
Keyword(s):  
Cancer Research ◽  
Trace Elements ◽  
Photodynamic Therapy ◽  
Normal Tissue ◽  
Second Generation ◽  
Tumor Tissue ◽  
Photodynamic Effect ◽  
Malignant Tumours ◽  
Local Destruction

Photodynamic therapy (PDT) is a promising approach to the local destruction of malignant tumours. This method is based on the partially selective retension in tumor tissue of the photosensitizers which have photodynamic effect. It is important for PDT to determine the photosentizer concentration in tumor and in normal tissue. We quantitatively analysed the concentration of the metallic phthalocyanines, a class of photosensitizers now recognized as “second generation” PDT drugs and studied its action in different time by PIXE technique. The paper shows also the correlation between trace elements and cancer.

scholarly journals Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

2018 ◽  
Vol 6 (4) ◽  
pp. 746-765 ◽  
Author(s):  
Houjuan Zhu ◽  
Penghui Cheng ◽  
Peng Chen ◽  
Kanyi Pu
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Spatial Resolution ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Recent Progress ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Ablation Efficiency ◽  
Excellent Spatial Resolution

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.

Assessment of the relevance of GaPc substituted with azido-polyethylene glycol chains for photodynamic therapy. Design, synthetic strategy, fluorescence, singlet oxygen generation, and pH-dependent spectroscopic behaviour

2017 ◽  
Vol 41 (18) ◽  
pp. 10027-10036 ◽  
Author(s):  
Veysel Koç ◽  
Sevinc Zehra Topal ◽  
Duygu Aydın Tekdaş ◽  
Özge Dilara Ateş ◽  
Emel Önal ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polyethylene Glycol ◽  
Singlet Oxygen ◽  
Synthetic Route ◽  
Spectroscopic Behaviour ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Synthetic Strategy ◽  
Ph Dependent ◽  
Therapy Design

New synthetic route and PDT potential of symmetrically and asymmetrically substituted Ga(iii)Pcs with terminal azides.

New sensitizers for photodynamic therapy. Controlled synthesis of purpurins and their effect on normal tissue

1989 ◽  
Vol 32 (4) ◽  
pp. 904-908 ◽  
Author(s):  
Alan R. Morgan ◽  
Ashraff Rampersaud ◽  
Greta M. Garbo ◽  
Rick W. Keck ◽  
Steven H. Selman
Keyword(s):  
Photodynamic Therapy ◽  
Normal Tissue ◽  
Controlled Synthesis

pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride-Porphyrin Nanoprobe

ChemPlusChem ◽  
2016 ◽  
Vol 81 (6) ◽  
pp. 535-540 ◽  
Author(s):  
Chi-Fai Chan ◽  
Yan Zhou ◽  
Hongyu Guo ◽  
Junying Zhang ◽  
Lijun Jiang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Carbon Nitride ◽  
Water Soluble ◽  
Ph Dependent

ChemInform Abstract: New Sensitizers for Photodynamic Therapy: Controlled Synthesis of Purpurins and Their Effect on Normal Tissue.

ChemInform ◽  
1989 ◽  
Vol 20 (38) ◽  
Author(s):  
A. R. MORGAN ◽  
A. RAMPERSAUD ◽  
G. M. GARBO ◽  
R. W. KECK ◽  
S. H. SELMAN
Keyword(s):  
Photodynamic Therapy ◽  
Normal Tissue ◽  
Controlled Synthesis
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