APPLICATION OF PIXE TO CANCER RESEARCH

1992 ◽  
Vol 02 (04) ◽  
pp. 529-534 ◽  
Author(s):  
HUIYING YAO ◽  
XIANZHOU ZENG ◽  
JIYAO CHEN ◽  
WEN CHEN ◽  
HUAIXIN CAI ◽  
...  

Photodynamic therapy (PDT) is a promising approach to the local destruction of malignant tumours. This method is based on the partially selective retension in tumor tissue of the photosensitizers which have photodynamic effect. It is important for PDT to determine the photosentizer concentration in tumor and in normal tissue. We quantitatively analysed the concentration of the metallic phthalocyanines, a class of photosensitizers now recognized as “second generation” PDT drugs and studied its action in different time by PIXE technique. The paper shows also the correlation between trace elements and cancer.

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Rui Chen ◽  
Luzhong Zhang ◽  
Jian Gao ◽  
Wei Wu ◽  
Yong Hu ◽  
...  

Hydrogen peroxide is a signal molecule of the tumor, and its overproduction makes a higher concentration in tumor tissue compared to normal tissue. Based on the fact that peroxalates can make chemiluminescence with a high efficiency in the presence of hydrogen peroxide, we developed nanomicelles composed of peroxalate ester oligomers and fluorescent dyes, called peroxalate nanomicelles (POMs), which could image hydrogen peroxide with high sensitivity and stability. The potential application of the POMs in photodynamic therapy (PDT) for cancer was also investigated. It was found that the PDT-drug-loaded POMs were sensitive to hydrogen peroxide, and the PDT drug could be stimulated by the chemiluminescence from the reaction between POMs and hydrogen peroxide, which carried on a self-therapy of the tumor without the additional laser light resource.


2002 ◽  
Vol 85 (2) ◽  
pp. 131-150 ◽  
Author(s):  
Hugh Barr ◽  
Catherine Kendall ◽  
Janelle Reyes-Goddard ◽  
Nicolas Stone

Photodynamic therapy is a method for local destruction of tissue or organisms by generating toxic oxygen and other reactive species using light absorbed by an administered or an endogenously generated photosensitiser. It is a highly promising treatment for patients with cancer. More recently it has found increasing use as a method of therapy for non-cancerous illnesses. It depends on the exploitation of natural and vital reactions widespread in nature that have driven and preserved life on this planet. Following administration of a photosensitiser or its precursor there is an accumulation or retention in areas of cancer and disease relative to adjacent normal tissue. The photosensitiser is inactive until irradiated by light, following which cellular destruction occurs. The clear attraction of this method is the possibility of some targeting of the disease by drug and by the area irradiated. This explanation although oversimplified has been the reason for the scientific and clinical interest in photodynamic therapy. An understanding of evolutionary photobiology is enormously helpful to understand disease response and clinical outcomes.


2019 ◽  
Vol 18 (2) ◽  
pp. 336-342 ◽  
Author(s):  
Álvaro F. Magalhães ◽  
Vânia C. Graça ◽  
Ricardo C. Calhelha ◽  
I. L. Ferreira Machado ◽  
L. F. Vieira Ferreira ◽  
...  

Squaraine dyes have recently attracted interest as potential second generation photosensitizers for photodynamic therapy.


2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 10575-10575 ◽  
Author(s):  
R. T. Aharonov ◽  
S. Rosenwald ◽  
T. B. Edmonston ◽  
I. Barshack ◽  
M. Feinmesser ◽  
...  

2018 ◽  
Vol 6 (4) ◽  
pp. 746-765 ◽  
Author(s):  
Houjuan Zhu ◽  
Penghui Cheng ◽  
Peng Chen ◽  
Kanyi Pu

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.


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