The Quest for New Anticoagulants: From Clinical Development to Clinical Practice

2010 ◽  
Vol 29 (6) ◽  
pp. e12-e22 ◽  
Author(s):  
Stavros Apostolakis ◽  
Gregory YH Lip ◽  
Deirdre A Lane ◽  
Eduard Shantsila
1995 ◽  
Vol 62 (2) ◽  
pp. 188-195
Author(s):  
R. Pianon ◽  
A. D'Amico ◽  
M. Rahmati ◽  
A. Paganelli ◽  
D. Schiavone ◽  
...  

The aim of this work is to try to characterize the prognostic value of DNA flow cytometry in superficial bladder tumours and to try to indicate this investigation in clinical practice. The Authors review results reported in literature and those relative to their experience. Data investigation shows that this test has prognostic significance because it is correlated with the stage and grade of the tumour. The correlation with the clinical development of the tumour is not clear in the Authors’ experience. The Authors think that flow cytometry does not have a precise role in clinical practice.


Hematology ◽  
2014 ◽  
Vol 2014 (1) ◽  
pp. 297-305 ◽  
Author(s):  
Stephan Moll

Abstract Several advances have occurred over the last 2 years in the clinical management of venous thromboembolism (VTE), as evidenced by several high-profile publications in top-tier medical journals. The translation of the knowledge gained into routine clinical practice is an important challenge so that VTE is managed optimally and established and new anticoagulants are used effectively and safely. This chapter reviews issues of VTE treatment from acute management to treatment of long-term complications, addressing new data gained in the last 2 years and putting them into a clinical context, with the goal of improved everyday VTE management.


2016 ◽  
Vol 94 (5) ◽  
pp. 383-387
Author(s):  
Igor N. Bokarev ◽  
T. B. Kondrat’eva

We analyze the effectiveness of new oral anticoagulants and antivitamins K for the treatment of patients with venous problems, atrial fibrillation, and acute coronary syndrome with reference to advantages of this therapy and methods of prevention of complications of these conditions.


2013 ◽  
Vol 17 (5) ◽  
pp. 340-346 ◽  
Author(s):  
Kim Papp ◽  
Marc Bourcier ◽  
Vincent Ho ◽  
Karen Burke ◽  
Boulos Haraoui

Background: Patents on several biologies will expire in Canada in the coming years. As they expire, applications to market subsequent entry biologies (SEBs) may be filed in Canada. Objective: To provide an understanding of the regulatory pathway and types of trials used for SEB authorization in Canada. Methods: Health Canada's draft guidance on SEBs was reviewed in regards to key issues and challenges in the development and authorization of SEBs. Results: Health Canada states that SEBs are not “generic biologies” and their authorization is not a declaration of pharmaceutical or therapeutic equivalence to the originator. The agency recommends that physicians make well-informed decisions regarding therapeutic interchange. Conclusions: Decisions on how to determine the place of SEBs in clinical practice for biologic-naive patients and those already receiving biologies should be made on a case-by-case basis, considering the patient's needs, the characteristics of the biologic required, and the clinical development programs of the applicable SEB.


Author(s):  
Jianshu Wei ◽  
Yelei Guo ◽  
Yao Wang ◽  
Zhiqiang Wu ◽  
Jian Bo ◽  
...  

Abstract Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in the treatment of hematological malignancies. In recent years, fast-growing CAR T clinical trials have actively explored their potential application scenarios. According to the data from the clinicaltrials.gov website, China became the country with the most registered CAR T trials in September 2017. As of June 30, 2020, the number of registered CAR T trials in China has reached 357. In addition, as many as 150 other CAR T trials have been registered on ChiCTR. Although CAR T therapy is flourishing in China, there are still some problems that cannot be ignored. In this review, we aim to systematically summarize the clinical practice of CAR T-cell therapy in China. This review will provide an informative reference for colleagues in the field, and a better understanding of the history and current situation will help us more reasonably conduct research and promote cooperation.


Breast Care ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. 174-176 ◽  
Author(s):  
Johannes Ettl

Palbociclib is the first inhibitor of the cyclin-dependent kinases (CDK) 4 and 6 to be introduced into clinical practice. Preclinical investigations led to its clinical development in advanced hormone receptor (HR)-positive breast cancer. To date, 2 significant clinical trials have been fully published. In this article, the results of these trials and their clinical relevance for the management of HR-positive advanced breast cancer are discussed.


2016 ◽  
Vol 157 (38) ◽  
pp. 1507-1510
Author(s):  
Róbert Gábor Kiss

Antithrombotic drug therapy is a main cornerstone – sometimes a fairly uneven cornerstone – of today’s clinical practice. Patients treated with antithrombotic drugs appear sometimes unawaited at those of our colleagues, who are not necessarily experts of this narrow field. Furthermore, new and newer molecules of antiplatelet and anticoagulant medicines have come into practice, frequently in combination. This dramatic development has been important to patients; pharmacological – and recently nonpharmacological – antithrombotic treatment has paved the way to improve current modalities in cardiology. Combining elements of the “old four” (heparin, coumadin, aspirin, clopidogrel) have been the basis of any improvement for a long time. Nowadays, there has been an involvement of new drugs, direct oral anticoagulants into practice. It is time now to catch up in using new anticoagulants, regardless of our current speciality in medicine. Orv. Hetil., 2016, 157(38), 1507–1510.


2020 ◽  
Vol 7 (1) ◽  
pp. 559-587
Author(s):  
Sourabh Shukla ◽  
He Hu ◽  
Hui Cai ◽  
Soo-Khim Chan ◽  
Christine E. Boone ◽  
...  

Viral nanotechnology exploits the prefabricated nanostructures of viruses, which are already abundant in nature. With well-defined molecular architectures, viral nanocarriers offer unprecedented opportunities for precise structural and functional manipulation using genetic engineering and/or bio-orthogonal chemistries. In this manner, they can be loaded with diverse molecular payloads for targeted delivery. Mammalian viruses are already established in the clinic for gene therapy and immunotherapy, and inactivated viruses or virus-like particles have long been used as vaccines. More recently, plant viruses and bacteriophages have been developed as nanocarriers for diagnostic imaging, vaccine and drug delivery, and combined diagnosis/therapy (theranostics). The first wave of these novel virus-based tools has completed clinical development and is poised to make an impact on clinical practice.


2009 ◽  
Vol 81 (6) ◽  
Author(s):  
Leszek Czerchawski ◽  
Wojciech Witkiewicz

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