Inhibitory effect ofAstragalus membranaceusroot on matrix metalloproteinase-1 collagenase expression and procollagen destruction in ultraviolet B-irradiated human dermal fibroblasts by suppressing nuclear factor kappa-B activity

2012 ◽  
Vol 65 (1) ◽  
pp. 142-148 ◽  
Author(s):  
Min Jung Hong ◽  
Eun Bit Ko ◽  
Seong Kyu Park ◽  
Mun Seog Chang
Keyword(s):  
Matrix Metalloproteinase ◽  
Nuclear Factor Kappa B ◽  
Inhibitory Effect ◽  
Dermal Fibroblasts ◽  
Ultraviolet B ◽  
Nuclear Factor ◽  
Human Dermal Fibroblasts ◽  
Nuclear Factor Kappa ◽  
Matrix Metalloproteinase 1

scholarly journals Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Lalita Subedi ◽  
So-Hyeon Baek ◽  
Sun Yeou Kim
Keyword(s):  
Protein Kinase ◽  
Nuclear Factor Kappa B ◽  
Genetically Engineered ◽  
Dermal Fibroblasts ◽  
Ultraviolet B ◽  
Mitogen Activated Protein Kinase ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Mitogen Activated Protein ◽  
Inflammatory Proteins

Resveratrol, a natural stilbenoid, is produced by several plants, especially grape vines. Its strong potency against obesity, metabolic disorders, vascular disease, inflammation, and various cancers has already been reported. Large amounts of wine or grapes need to be consumed to obtain the amount of resveratrol required for biological activity. Pure resveratrol at concentrations as low as 10 μM induces cytotoxicity to normal cells. To overcome these limitations, we prepared genetically modified resveratrol-enriched rice (RR). We previously reported the strong antiaging potential of RR against ultraviolet B/reactive oxygen species-induced toxicity in normal human dermal fibroblasts (NHDF). As aging is characterized by neuroinflammation and neurodegeneration, we further evaluated the role of RR against LPS-induced neuroinflammation. RR inhibited nitric oxide production and the expression of inflammatory proteins such as iNOS and COX-2. RR significantly modulated mitogen-activated protein kinase signaling, activator protein AP-1 signaling, and nuclear factor kappa B (NF-κB) mediated transcription of inflammatory proteins via inhibition of NF-κB translocation, IkB phosphorylation, and proinflammatory cytokine productions such as interleukin IL-6, IL-1β, tumor necrosis factor alpha (TNF-α), and prostaglandin E2 (PGE2). These findings show that the strong antineuroinflammatory effects of RR can be beneficial for aging-mediated neurodegenerative conditions as well as disorders of the central nervous system caused by neuroinflammation.

Baicalein inhibits matrix metalloproteinase 1 expression via activation of TRPV 1‐Ca‐ ERK pathway in ultraviolet B–irradiated human dermal fibroblasts

2019 ◽  
Vol 28 (5) ◽  
pp. 568-575 ◽  
Author(s):  
Kuo‐Feng Huang ◽  
Kuo‐Hsing Ma ◽  
Yen‐Jung Chang ◽  
Liang‐Chuan Lo ◽  
Tian‐You Jhap ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dermal Fibroblasts ◽  
Ultraviolet B ◽  
Erk Pathway ◽  
Human Dermal Fibroblasts ◽  
Matrix Metalloproteinase 1

scholarly journals Inhibitory Effect of Opuntia humifusa Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression

2018 ◽  
Vol 19 (9) ◽  
pp. 2503 ◽  
Author(s):  
Ah-Ram Han ◽  
Tae-Gyu Lim ◽  
Young-Ran Song ◽  
Mi Jang ◽  
Young Rhee ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Radical Scavenging ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Dermal Fibroblasts ◽  
Ros Generation ◽  
Skin Damage ◽  
Opuntia Humifusa ◽  
Matrix Metalloproteinase 1 ◽  
Solar Ultraviolet

Opuntia humifusa is a type of cactus whose fruits have been used in folk medicine for the treatment of several diseases. In the present study, we aimed to determine whether O. humifusa fruit water extract (OHE) has inhibitory effects against solar ultraviolet (sUV)-induced matrix metalloproteinase-1 (MMP-1) expression. In ex vivo human skin, we found that OHE suppressed sUV radiation-induced MMP-1 expression. The inhibitory effect of OHE was confirmed in human dermal fibroblasts. OHE treatment reduced sUV-induced MMP-1 expression by suppressing reactive oxygen species (ROS) generation and phosphorylation of c-Jun, a component of transcription factor activator protein 1 (AP-1). On the other hand, OHE recovered the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and type 1 collagen production attenuated by sUV. As upstream signaling pathways for AP-1, MKK4-JNK, MEK-ERK, and MKK3/6-p38 phosphorylation were downregulated by OHE treatment. In addition, OHE exhibited DPPH radical scavenging activity. These findings demonstrate that OHE has a preventive effect against sUV-induced skin damage via suppression of pathways triggered by ROS.

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