scholarly journals Systemic inflammation and the relationship between periodontitis, edentulism and all‐cause mortality: a 17‐year prospective cohort study

2021 ◽  
Author(s):  
Lewis Winning ◽  
Christopher C. Patterson ◽  
Katie Linden ◽  
Kathy M. Cullen ◽  
Frank Kee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Systemic Inflammation ◽  
Prospective Cohort ◽  
All Cause Mortality ◽  
The Relationship

Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study

2019 ◽  
Vol 35 (5) ◽  
pp. 854-860 ◽  
Author(s):  
Jun Morinaga ◽  
Tatsuyuki Kakuma ◽  
Hirotaka Fukami ◽  
Manabu Hayata ◽  
Kohei Uchimura ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Mortality Risk ◽  
Prospective Cohort ◽  
Premature Aging ◽  
Skewed Distribution ◽  
Maintenance Hemodialysis ◽  
All Cause Mortality ◽  
Uremic Patients ◽  
The Relationship

Abstract Background Patients undergoing hemodialysis treatment have a poor prognosis, as many develop premature aging. Systemic inflammatory conditions often underlie premature aging phenotypes in uremic patients. We investigated whether angiopoietin-like protein 2 (ANGPTL 2), a factor that accelerates the progression of aging-related and noninfectious inflammatory diseases, was associated with increased mortality risk in hemodialysis patients. Methods We conducted a multicenter prospective cohort study of 412 patients receiving maintenance hemodialysis and evaluated the relationship between circulating ANGPTL2 levels and the risk for all-cause mortality. Circulating ANGPTL2 levels were log-transformed to correct for skewed distribution and analyzed as a continuous variable. Results Of 412 patients, 395 were included for statistical analysis. Time-to-event data analysis showed high circulating ANGPTL2 levels were associated with an increased risk for all-cause mortality after adjustment for age, sex, hemodialysis vintage, nutritional status, metabolic parameters and circulating high-sensitivity C-reactive protein levels {hazard ratio [HR] 2.04 [95% confidence interval (CI) 1.10–3.77]}. High circulating ANGPTL2 levels were also strongly associated with an increased mortality risk, particularly in patients with a relatively benign prognostic profile [HR 3.06 (95% CI 1.86–5.03)]. Furthermore, the relationship between circulating ANGPTL2 levels and mortality risk was particularly strong in patients showing few aging-related phenotypes, such as younger patients [HR 7.99 (95% CI 3.55–18.01)], patients with a short hemodialysis vintage [HR 3.99 (95% CI 2.85–5.58)] and nondiabetic patients [HR 5.15 (95% CI 3.19–8.32)]. Conclusion We conclude that circulating ANGPTL2 levels are positively associated with mortality risk in patients receiving maintenance hemodialysis and that ANGPTL2 could be a unique marker for the progression of premature aging and subsequent mortality risk in uremic patients, except those with significant aging-related phenotypes.

scholarly journals Depression, non-fatal stroke and all-cause mortality in old age: A prospective cohort study of primary care patients

2013 ◽  
Vol 150 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Sebastian Köhler ◽  
Frans Verhey ◽  
Siegfried Weyerer ◽  
Birgitt Wiese ◽  
Kathrin Heser ◽  
...  
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Old Age ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Fatal Stroke ◽  
All Cause Mortality ◽  
Primary Care Patients

scholarly journals All-cause mortality and periodontitis in 60-70-year-old men: a prospective cohort study

2012 ◽  
Vol 39 (10) ◽  
pp. 940-946 ◽  
Author(s):  
Gerard J. Linden ◽  
Katie Linden ◽  
John Yarnell ◽  
Alun Evans ◽  
Frank Kee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
All Cause Mortality ◽  
Old Men

THE RELATIONSHIP BETWEEN DIENOGEST (VISANNE®) AND DEPRESSIVE SYMPTOMS: A PROSPECTIVE COHORT STUDY

2021 ◽  
Vol 116 (3) ◽  
pp. e364-e365
Author(s):  
Sung Pil Choo ◽  
SiHyun Cho ◽  
Jung-Ho Shin ◽  
Nayoung Bae ◽  
So Hyun Ahn
Keyword(s):  
Cohort Study ◽  
Depressive Symptoms ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
The Relationship

scholarly journals The associations of dietary patterns with all-cause mortality and other lifestyle factors in the elderly: An age-specific prospective cohort study

2019 ◽  
Vol 38 (1) ◽  
pp. 288-296 ◽  
Author(s):  
Wenjing Zhao ◽  
Shigekazu Ukawa ◽  
Emiko Okada ◽  
Kenji Wakai ◽  
Takashi Kawamura ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Dietary Patterns ◽  
Prospective Cohort ◽  
The Elderly ◽  
Lifestyle Factors ◽  
All Cause Mortality
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