Uric Acid Variability and All-Cause Mortality: A Prospective Cohort Study in Northern China

2021 ◽  
Author(s):  
M. Wang ◽  
C. Wang ◽  
M. Zhao ◽  
Y. Li ◽  
S. Yao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Northern China ◽  
All Cause Mortality

Relationship between Serum Uric Acid and Mortality Risk in Hemodialysis Patients: A Multicenter Prospective Cohort Study

2020 ◽  
Vol 51 (10) ◽  
pp. 823-832
Author(s):  
Yaya Yang ◽  
Xianhui Qin ◽  
Yumin Li ◽  
Shenglin Yang ◽  
Junzhi Chen ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Mortality Risk ◽  
Prospective Cohort ◽  
All Cause Mortality ◽  
Multicenter Prospective Cohort Study ◽  
Multicenter Prospective Cohort ◽  
Cvd Mortality

<b><i>Background:</i></b> Several studies have reported that low serum uric acid (SUA) levels are related to increased risk of mortality in maintenance hemodialysis (MHD) patients. However, the possible detrimental effects of high SUA on the mortality risk have not been well examined. Moreover, the possible effect modifiers for the SUA-mortality association have not been fully investigated. To address the aforementioned gap, we aimed to explore the nonlinear relationship between SUA levels and all-cause and cardiovascular disease (CVD) mortality risk, and to examine any possible effect modifiers in MHD patients. <b><i>Methods:</i></b> We conducted a multicenter, prospective cohort study among 1,018 MHD patients from 8 hemodialysis centers. The primary outcome was all-cause mortality, and the secondary outcomes were CVD mortality and non-CVD mortality. <b><i>Results:</i></b> The mean value for SUA in the total population was 8.5 ± 1.9 mg/dL. The lowest and highest quintiles of SUA were &#x3c;7.0 and &#x3e;10.1 mg/dL, respectively. Over a median follow-up of 45.6 months, 343 deaths were recorded, of which 202 (58.9%) were due to CVD. When SUA was assessed as quintiles, a significantly higher risk of all-cause mortality was found in patients in quintile 1 (&#x3c;7.0 mg/dL; hazard ratio [HR], 1.33; 95% confidence interval [CI]: 1.02–1.73) or quintile 5 (≥10.1 mg/dL; HR, 1.47; 95% CI: 1.09–2.00), compared to those in quintiles 2–4 (7–10.1 mg/dL). Moreover, the U-shaped SUA-mortality association was mainly found in those with lower C-reactive protein levels (&#x3c;3 compared with ≥3 mg/L; <i>p</i> for interaction = 0.018). Similar trends were found for CVD mortality and non-CVD mortality. <b><i>Conclusion:</i></b> There was a U-shaped relationship between SUA levels and the risk of all-cause mortality, CVD mortality, and non-CVD mortality in MHD patients.

scholarly journals Depression, non-fatal stroke and all-cause mortality in old age: A prospective cohort study of primary care patients

2013 ◽  
Vol 150 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Sebastian Köhler ◽  
Frans Verhey ◽  
Siegfried Weyerer ◽  
Birgitt Wiese ◽  
Kathrin Heser ◽  
...  
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Old Age ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Fatal Stroke ◽  
All Cause Mortality ◽  
Primary Care Patients

scholarly journals All-cause mortality and periodontitis in 60-70-year-old men: a prospective cohort study

2012 ◽  
Vol 39 (10) ◽  
pp. 940-946 ◽  
Author(s):  
Gerard J. Linden ◽  
Katie Linden ◽  
John Yarnell ◽  
Alun Evans ◽  
Frank Kee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
All Cause Mortality ◽  
Old Men

scholarly journals The associations of dietary patterns with all-cause mortality and other lifestyle factors in the elderly: An age-specific prospective cohort study

2019 ◽  
Vol 38 (1) ◽  
pp. 288-296 ◽  
Author(s):  
Wenjing Zhao ◽  
Shigekazu Ukawa ◽  
Emiko Okada ◽  
Kenji Wakai ◽  
Takashi Kawamura ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Dietary Patterns ◽  
Prospective Cohort ◽  
The Elderly ◽  
Lifestyle Factors ◽  
All Cause Mortality
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