A head‐to‐head comparison of risankizumab and ixekizumab for genital psoriasis: a real‐life, 24‐week, prospective study.

Author(s):  
E Sotiriou ◽  
K Bakirtzi ◽  
I Papadimitriou ◽  
A Tsentemeidou ◽  
P Eftychidou ◽  
...  

Author(s):  
A.T. Touhouche ◽  
M. Cassagne ◽  
E. Bérard ◽  
F. Giordano‐Labadie ◽  
A. Didier ◽  
...  


2019 ◽  
Vol 229 (3) ◽  
pp. 277-285 ◽  
Author(s):  
Charles Sabbagh ◽  
Loréna Masseline ◽  
Gérard Grelpois ◽  
Alexandre Ntouba ◽  
Jeanne Dembinski ◽  
...  






2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Marine Lesourd ◽  
Jean Baptiste Beauval ◽  
Benjamin Pradere ◽  
Daniel Portalez ◽  
Xavier Gamé ◽  
...  


Thorax ◽  
2017 ◽  
Vol 73 (8) ◽  
pp. 782-784 ◽  
Author(s):  
Maria del Carmen Vennera ◽  
Carlos Sabadell ◽  
Cesar Picado

Efficacy of omalizumab in severe asthma is well documented; however, the optimal duration of the treatment remains unclear. In an open prospective study, we sought to assess the persistence of response in subjects withdrawing from omalizumab treatment. We evaluated 49 patients who voluntarily accepted to discontinue omalizumab treatment after 6 years of therapy. Asthma relapse was defined as any severe asthma exacerbation associated with loss of asthma control. Twelve patients relapsed in the first year of follow-up, and 7 within 13 and 48 months. These results suggest that the effects of 6 years of omalizumab may persist after discontinuation of therapy in 60% of patients for at least 4 years.



Author(s):  
Marietta Iacucci ◽  
Samuel C.L. Smith ◽  
Alina Bazarova ◽  
Uday N. Shivaji ◽  
Pradeep Bhandari ◽  
...  


2020 ◽  
Author(s):  
Laura Courtellemont ◽  
jerome Guinard ◽  
Clemence Guillaume ◽  
Susanna Giache ◽  
Vincent Rzepecki ◽  
...  

Introduction The SARS-CoV-2 pandemic has become a major public health issue worldwide. Developing and evaluating rapid and easy-to-perform diagnostic tests is an absolute priority. The current prospective study was designed to assess diagnostic performances of an antigen-based rapid detection test (COVID-VIRO) in a real-life setting. Methods Two nasopharyngeal specimens of symptomatic or asymptomatic adult patients hospitalized in the Infectious Diseases Department or voluntarily accessing the COVID-19 Screening Department of the Regional Hospital of Orleans, France, were concurrently collected. COVID VIRO diagnostic specificity and sensitivity were assessed in comparison to real-time reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) results. A subgroup of patients underwent an additional oropharyngeal and/or a saliva swab for rapid testing. Results 121 patients already having a confirmed infection and 127 patients having no evidence of recent or ongoing infection were enrolled, for a total of 248 couple of nasopharyngeal swab specimens. Overall COVID-VIRO sensitivity was 96.7% (IC: 93.5%-99.9%). In asymptomatic patients, patients having symptoms for more than 4 days and those having a RT-qPCR Cycle threshold value >32, sensitivity was of 100%, 95.8% and 96.9% respectively. The concordance between RT-qPCR and COVID VIRO rapid test was 100% for the 127 patients with no SARS-CoV-2 infection. Conclusion COVID-VIRO test had 100% specificity and above 95% sensitivity, better than WHO recommendations (specificity ≥97-100%, sensitivity ≥80%). These rapid tests are particularly interesting for large-scale screening in Emergency Department, low resource settings and airports.



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