The effects of temperature and dissolved oxygen on antioxidant defences and oxidative damage in the fathead minnow Pimephales promelas

2013 ◽  
Vol 82 (3) ◽  
pp. 1086-1092 ◽  
Author(s):  
E. D. Clotfelter ◽  
S. J. H. Lapidus ◽  
A. C. Brown
Keyword(s):  
Oxidative Damage ◽  
Dissolved Oxygen ◽  
Fathead Minnow ◽  
Pimephales Promelas ◽  
Antioxidant Defences ◽  
Effects Of Temperature

Chronic Effects of Low Dissolved Oxygen Concentrations on the Fathead Minnow (Pimephales promelas)

1971 ◽  
Vol 28 (8) ◽  
pp. 1119-1123 ◽  
Author(s):  
William A. Brungs
Keyword(s):  
Dissolved Oxygen ◽  
Fathead Minnow ◽  
Pimephales Promelas ◽  
Fathead Minnows ◽  
Low Dissolved Oxygen ◽  
Chronic Effects ◽  
Lower Oxygen ◽  
Time Required ◽  
Oxygen Concentrations

Fathead minnows were exposed to constant dissolved oxygen concentrations (1.0–5.0 mg/liter) for 11 months. The number of eggs produced per female was reduced at 2.0 mg/liter; no spawning occurred at 1.0 mg/liter. Fry growth was reduced significantly at all concentrations below the control (7.9 mg/liter). Fry survival was reduced at 4.0 mg/liter and lower dissolved oxygen concentrations; 18% of the survivors at 4.0 mg/liter were deformed. The time required for hatching was increased at successively lower oxygen concentrations by as much as 50% (from 5.0 under control conditions to 7.8 days at 2.0 mg/liter), but no effect on percentage hatch was observed.

Responses in a Fathead Minnow (Pimephales promelas) Lifecycle Test and in Wild White Sucker (Catostomus commersoni) Exposed to a Canadian Bleached Kraft Mill Effluent

2010 ◽  
Vol 45 (2) ◽  
pp. 187-200 ◽  
Author(s):  
Joanne L. Parrott ◽  
L. Mark Hewitt ◽  
Tibor G. Kovacs ◽  
Deborah L. MacLatchy ◽  
Pierre H. Martel ◽  
...  
Keyword(s):  
Egg Production ◽  
Fathead Minnow ◽  
Pimephales Promelas ◽  
Fish Reproduction ◽  
White Sucker ◽  
Catostomus Commersoni ◽  
Liver Size ◽  
Paper Mill Effluent ◽  
Kraft Mill Effluent ◽  
Kraft Mill

Abstract To evaluate currently available bioassays for their use in investigating the causes of pulp and paper mill effluent effects on fish reproduction, the responses of wild white sucker (Catostomus commersoni) collected from the receiving environment at the bleached kraft mill at La Tuque, Quebec, were compared with responses of fathead minnow (Pimephales promelas) exposed to effluent in a laboratory lifecycle test. White sucker collected at effluent exposed sites had increased liver size but none of the reproductive effects that had been documented in earlier field studies at this site. Exposure to 1, 3, 10, 30, and 100% bleached kraft mill effluent (BKME) in the lab led to significantly decreased length, but increased weight and liver size in male fathead minnow. Female length was also decreased and liver size was increased at high effluent exposures. Most effluent concentrations (1 to 30%) significantly increased egg production compared with controls. The fathead minnow lifecycle assay mirrored the effects seen in wild fish captured downstream of the BKME discharge. These results will be used to select short-term fish tests for investigating the causes of and solutions to the effects of mill effluents on fish reproduction.

scholarly journals nLethal and sublethal effects of diluted bitumen and conventional oil on fathead minnow (Pimephales promelas) larvae exposed during their early development

2021 ◽  
pp. 105884
Author(s):  
Roxanne Bérubé ◽  
Charles Gauthier ◽  
Thibault Bourdin ◽  
Marilou Bouffard ◽  
Gaëlle Triffault-Bouchet ◽  
...  
Keyword(s):  
Early Development ◽  
Fathead Minnow ◽  
Sublethal Effects ◽  
Pimephales Promelas ◽  
Conventional Oil

Environmental Gestagens Activate Fathead Minnow (Pimephales promelas) Nuclear Progesterone and Androgen Receptors in Vitro

2014 ◽  
Vol 48 (14) ◽  
pp. 8179-8187 ◽  
Author(s):  
Laura E. Ellestad ◽  
Mary Cardon ◽  
Ian G. Chambers ◽  
Jennifer L. Farmer ◽  
Phillip Hartig ◽  
...  
Keyword(s):  
Fathead Minnow ◽  
Androgen Receptors ◽  
Pimephales Promelas

scholarly journals Antioxidant strategies for Alzheimer's disease

2002 ◽  
Vol 61 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Michael Grundman ◽  
Patrick Delaney
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin E ◽  
Oxidative Damage ◽  
Functional Decline ◽  
Antioxidant Properties ◽  
Epidemiological Studies ◽  
Clinical Value ◽  
Antioxidant Defences ◽  
Ad Prevention

Oxidative damage is present within the brains of patients with Alzheimer's disease (AD), and is observed within every class of biomolecule, including nucleic acids, proteins, lipids and carbohydrates. Oxidative injury may develop secondary to excessive oxidative stress resulting from β-amyloid-induced free radicals, mitochondrial abnormalities, inadequate energy supply, inflammation or altered antioxidant defences. Treatment with antioxidants is a promising approach for slowing disease progression to the extent that oxidative damage may be responsible for the cognitive and functional decline observed in AD. Although not a uniformly consistent observation, a number of epidemiological studies have found a link between antioxidant intake and a reduced incidence of dementia, AD and cognitive decline in elderly populations. In AD clinical trials molecules with antioxidant properties such as vitamin E andGinkgo bilobaextract have shown modest benefit. A clinical trial with vitamin E is currently ongoing to determine if it can delay progression to AD in individuals with mild cognitive impairment. Combinations of antioxidants might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and ubiquinone). Naturally-occurring compounds with antioxidant capacity are available and widely marketed (e.g. vitamin C, ubiquinone, lipoic acid, β-carotene, creatine, melatonin, curcumin) and synthetic compounds are under development by industry. Nevertheless, the clinical value of these agents for AD prevention and treatment is ambiguous, and will remain so until properly designed human trials have been performed.

Effects of Long-Term Exposure to Carbaryl (Sevin) on Survival, Growth, and Reproduction of the Fathead Minnow (Pimephales promelas)

1972 ◽  
Vol 29 (5) ◽  
pp. 583-587 ◽  
Author(s):  
A. R. Carlson
Keyword(s):  
Life Cycle ◽  
Fathead Minnow ◽  
Pimephales Promelas ◽  
Threshold Concentration ◽  
Fathead Minnows ◽  
Motile Sperm ◽  
High Concentration ◽  
Toxicant Concentration ◽  
Growth And Reproduction

When fathead minnows (Pimephales promelas) were exposed to five concentrations (0.008–0.68 mg/liter) of the insecticide carbaryl for 9 months and throughout a life cycle, the highest concentration prevented reproduction and decreased survival. At the high concentration, testes contained motile sperm and ovaries were in a flaccid condition and appeared to be in a resorptive state. At the 0.68 mg/liter concentration, carbaryl appeared to contribute to mortality of larvae (produced by unexposed parents) within 30 days of hatching. Survival of young grown in the 0.008 mg/liter concentration was reduced. Since no demonstrable effects were noted for survival, growth, or reproduction at the 0.017, 0.062, and 0.21 mg/liter concentrations, this low survival value is considered not due to carbaryl. The 96-hr median tolerance concentration (TL 50) and the lethal threshold concentration (LTC) for 2-month-old fathead minnows were 9.0 mg/liter. The maximum acceptable toxicant concentration (MATC) for fathead minnows exposed to carbaryl in water with a hardness of 45.2 mg/liter and a pH of 7.5 lies between 0.21 and 0.68 mg/liter. The application factors (MATC/96-hr TL50 and MATC/LTC) both lie between 0.023 and 0.075.

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