Ajwain oil attenuates allergic response of ovalbumin‐induced allergic rhinitis via alteration of inflammatory, oxidative stress, and Th1/Th2 responses

2021 ◽  
Author(s):  
Jingjing Li ◽  
Prashant Raghav ◽  
Chunyan Hu
Keyword(s):  
Oxidative Stress ◽  
Allergic Rhinitis ◽  
Allergic Response ◽  
Th2 Responses

Overexpression of the Superoxide Anion and NADPH Oxidase Isoforms 1 and 4 (NOX1 and NOX4) in Allergic Nasal Mucosa

2009 ◽  
Vol 23 (4) ◽  
pp. 370-376 ◽  
Author(s):  
Joon Hwan Moon ◽  
Tae Hoon Kim ◽  
Heung Man Lee ◽  
Seung Hoon Lee ◽  
Whan Choe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Allergic Rhinitis ◽  
Nadph Oxidase ◽  
Nasal Mucosa ◽  
Vascular Endothelium ◽  
Superoxide Anion ◽  
Nasal Polyps ◽  
Inflammatory Cells ◽  
Submucosal Glands ◽  
Cellular Source

Background The purpose of this study was to investigate the expression and distribution of superoxide anion, NADPH oxidase (NOX)1, and NOX4 in healthy, allergic nasal mucosa and nasal polyps to evaluate the possible influence of oxidative stress on the development of allergic rhinitis and nasal polyps. Methods The expression and distribution of superoxide anion, NOX1 and NOX4 were evaluated in healthy and allergic nasal mucosa and nasal polyps, using dihydroethidium fluorescence, semiquantitative reverse transcriptase-polymerase chain reaction, immunohistochemistry, and Western blot. Results NOX1 and NOX4 were localized mainly in the epithelial layer, submucosal glands, vascular endothelium, and inflammatory cells in healthy and allergic nasal mucosa and nasal polyps. The cellular source that generated superoxide anion is also localized in the epithelial cells, submucosal glands, vascular endothelium, and inflammatory cells, demonstrating the similar sites of expression of NOX1 and NOX4 in healthy and allergic nasal mucosa and nasal polyps. NOX1 and NOX4 mRNA and proteins and superoxide anions had increased levels of expression in allergic nasal mucosa and nasal polyps compared with healthy nasal mucosa. Conclusions These results indicate that NOX1 and NOX4 may play an important role in reactive oxygen species production, contributing to the oxidative stress in allergic rhinitis and nasal polyp tissues.

scholarly journals Local allergic rhinitis

2014 ◽  
Vol 67 (suppl. 1) ◽  
pp. 49-56
Author(s):  
Maja Buljcik-Cupic ◽  
Dragana Lemez ◽  
Slobodan Savovic ◽  
Ljiljana Jovancevic ◽  
Danijela Dragicevic
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Immunoglobulin E ◽  
Provocation Test ◽  
Allergic Response ◽  
Prick Test ◽  
Local Allergic Rhinitis ◽  
Provocation Tests ◽  
Number Of Patients ◽  
The Impact

Local allergic rhinitis is a localized allergic response of the nasal mucosa to aeroallergens in the absence of atopy with characteristic production of specific local immunoglobulin E antibodies in the nasal mucosa, T helper type 2 cellular infiltration response during the exposure to aeroallergens and positive results via the nasal allergic provocation test with the release of inflammatory mediators (triptase and eosinophil cationic proteins). Even though the prevalence of local allergic rhinitis has been and is still being investigated, a large number of patients with diagnosed non-allergic rhinitis or idiopathic rhinitis are currently classified as having local allergic rhinitis. The causes of local allergic rhinitis are most commonly house dust, dust mites, pollens and many others. Diagnosis of local allergic rhinitis is made using nasal allergen provocation tests when the prick test for standard inhalation allergens and the serum specific immunoglobulin analysis for aeroallergens are negative. The increasing amount of data on localized allergic response in non-atopic patients asks for many answers regarding local allergic rhinitis. These answers can be obtained by a study on the prevalence and incidence in children and adults, the impact of positive family atopy in the development of disease, the impact of associated diseases of the lower respiratory tract and conjunctiva, the effectiveness of drug treatment and the issue of administration of specific immunotherapy.

A New Oxidative Stress Marker for Thiol-Disulphide Homeostasis in Seasonal Allergic Rhinitis

2016 ◽  
Vol 30 (3) ◽  
pp. e53-e57 ◽  
Author(s):  
Seckin Ulusoy ◽  
Nilhan Nurlu Ayan ◽  
Mehmet Emre Dinc ◽  
Abdulhalim Is ◽  
Cemile Bicer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Oxidative Stress Marker ◽  
Stress Marker

scholarly journals Anti-allergic and anti-inflammatory effects of resveratrol via inhibiting TXNIP-oxidative stress pathway in a mouse model of allergic rhinitis

2020 ◽  
Vol 13 (10) ◽  
pp. 100473
Author(s):  
Weitian Zhang ◽  
Ru Tang ◽  
Guangyi Ba ◽  
Mingxian Li ◽  
Hai Lin
Keyword(s):  
Oxidative Stress ◽  
Allergic Rhinitis ◽  
Mouse Model ◽  
Oxidative Stress Pathway ◽  
Anti Inflammatory ◽  
Stress Pathway

Nasal Allergic Response Mediated by Histamine H3 Receptors in Murine Allergic Rhinitis

2005 ◽  
Vol 115 (10) ◽  
pp. 1778-1784 ◽  
Author(s):  
Muneo Nakaya ◽  
Yasushi Fukushima ◽  
Naonobu Takeuchi ◽  
Kimitaka Kaga
Keyword(s):  
Allergic Rhinitis ◽  
Allergic Response ◽  
Histamine H3 Receptors ◽  
H3 Receptors ◽  
Histamine H3

scholarly journals Inhibition of Allergic Response by Intranasal Selective NF-κB Decoy Oligodeoxynucleotides in a Murine Model of Allergic Rhinitis

2017 ◽  
Vol 9 (1) ◽  
pp. 61 ◽  
Author(s):  
Jee Hye Wee ◽  
Yu-Lian Zhang ◽  
Chae-Seo Rhee ◽  
Dong-Young Kim
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Allergic Response

Oxidative stress in the airways of children with asthma and allergic rhinitis

2012 ◽  
Vol 23 (6) ◽  
pp. 556-561 ◽  
Author(s):  
Melda Celik ◽  
Ayfer Tuncer ◽  
Ozge U. Soyer ◽  
Cansın Saçkesen ◽  
H Tanju Besler ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Allergic Rhinitis ◽  
Children With Asthma

scholarly journals Increased oxidative stress in allergic rhinitis. Attention; Ruywayda Adams

2021 ◽  
Vol 8 (1) ◽  
pp. 01-02
Author(s):  
Hilary Solomons
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Cigarette Smoke ◽  
Environmental Exposure ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Ample Evidence ◽  
Allergic Disorders

There is ample evidence that allergic disorders such as asthma, rhinitis and atopic dermatitis are mediated by oxidative stress. Excessive exposure to reactive oxygen and nitrogen species is the hallmark of oxidative stress and leads to damage of proteins, lipids and DNA. Oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution and cigarette smoke.

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