Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease

2013 ◽  
Vol 275 (1) ◽  
pp. 71-83 ◽  
Author(s):  
X. Huang ◽  
P. Sjögren ◽  
J. Ärnlöv ◽  
T. Cederholm ◽  
L. Lind ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Kidney Disease ◽  
Serum Fatty Acid ◽  
The Metabolic Syndrome ◽  
Fatty Acid Patterns

The metabolic syndrome and chronic kidney disease

2006 ◽  
Vol 15 (4) ◽  
pp. 361-365 ◽  
Author(s):  
Carmen A Peralta ◽  
Manjula Kurella ◽  
Joan C Lo ◽  
Glenn M Chertow
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
The Metabolic Syndrome

scholarly journals The Metabolic Syndrome and Risk of Chronic Kidney Disease: Pathophysiology and Intervention Strategies

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Heather A. LaGuardia ◽  
L. Lee Hamm ◽  
Jing Chen
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Intervention Strategies ◽  
Elevated Blood ◽  
The Metabolic Syndrome ◽  
Prevalence Of Obesity ◽  
Complications And Mortality

Metabolic syndrome is characterized by a clustering of cardiovascular risk factors, including abdominal obesity, elevated blood pressure and glucose concentrations, and dyslipidemia. The presence of this clinical entity is becoming more pervasive throughout the globe as the prevalence of obesity increases worldwide. Moreover, there is increased recognition of the complications and mortality related to this syndrome. This paper looks to examine the link between metabolic syndrome and the development of chronic kidney disease.

scholarly journals The metabolic syndrome and chronic kidney disease in a Southeast Asian cohort

2007 ◽  
Vol 71 (7) ◽  
pp. 693-700 ◽  
Author(s):  
C. Kitiyakara ◽  
S. Yamwong ◽  
S. Cheepudomwit ◽  
S. Domrongkitchaiporn ◽  
N. Unkurapinun ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Southeast Asian ◽  
The Metabolic Syndrome ◽  
Asian Cohort

Associations of chronic kidney disease with the metabolic syndrome in non-diabetic elderly

2006 ◽  
Vol 21 (12) ◽  
pp. 3608-3609 ◽  
Author(s):  
M. Kanauchi ◽  
K. Kanauchi ◽  
K. Kimura ◽  
T. Inoue ◽  
Y. Saito
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
The Metabolic Syndrome

Risks of Nocturia in Patients with Chronic Kidney Disease—Do the Metabolic Syndrome and its Components Matter?

2012 ◽  
Vol 188 (6) ◽  
pp. 2269-2273 ◽  
Author(s):  
Mei-Yi Wu ◽  
Yi-Lien Wu ◽  
Yung-Ho Hsu ◽  
Yuh-Feng Lin ◽  
Yang-Chih Fan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
The Metabolic Syndrome

scholarly journals Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

Metabolites ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 98
Author(s):  
Justyna Korczyńska ◽  
Aleksandra Czumaj ◽  
Michał Chmielewski ◽  
Maciej Śledziński ◽  
Adriana Mika ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Kidney Disease ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Kidney Disease ◽  
Elevated Serum ◽  
Serum Levels ◽  
Mrna Levels ◽  
Serum Fatty Acid ◽  
Serum Leptin

Chronic kidney disease (CKD) is associated with an increased level of leptin and an abnormal fatty acid (FA) profile in the serum. However, there are no data on the associations between them, and the reason for increased serum levels in patients with CKD is not well elucidated. Recently, we found that a CKD-related abnormal FA profile caused significant changes in the expression of genes involved in lipid metabolism in hepatocytes. The aim of this study was to examine whether leptin gene expression in subcutaneous adipose tissue (SAT) of patients with CKD may contribute to increased serum levels of this adipokine and whether the abnormal serum FA profile observed in CKD patients has an impact on leptin gene expression in adipocytes. The FA profile was measured in serum samples from patients with CKD and controls by GC–MS. The relative mRNA levels of leptin were measured in SAT by Real-Time PCR. Moreover, the effect of the CKD-related abnormal FA profile on leptin gene expression was studied in in vitro cultured 3T3-L1 adipocytes. Patients with CKD had higher concentrations of serum leptin than controls and higher expression level of the leptin gene in SAT. They also had increased serum monounsaturated FAs and decreased polyunsaturated FAs. The incubation of adipocytes with FAs isolated from CKD patients resulted in an increase of the levels of leptin mRNA. Increased leptin gene expression in SAT may contribute to elevated concentrations of these adipokine in patients with CKD. CKD-related alterations of the FA profile may contribute to elevated serum leptin concentrations in patients with CKD by increasing the gene expression of this adipokine in SAT.

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