scholarly journals The actin‐regulating kinase homologue MoArk1 plays a pleiotropic function in M agnaporthe oryzae

2013 ◽  
Vol 14 (5) ◽  
pp. 470-482 ◽  
Author(s):  
Jiamei Wang ◽  
Yan Du ◽  
Haifeng Zhang ◽  
Chen Zhou ◽  
Zhongqiang Qi ◽  
...  
Keyword(s):  
Kinase Homologue ◽  
Pleiotropic Function

scholarly journals Adipokines and coronary artery disease

2015 ◽  
Vol 78 (3) ◽  
Author(s):  
Teresa Strisciuglio ◽  
Gennaro Galasso ◽  
Dario Leosco ◽  
Roberta De Rosa ◽  
Giuseppe Di Gioia ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Scientific Evidence ◽  
Behavioral Strategies ◽  
Physiological Processes ◽  
Pathological Conditions ◽  
Artery Disease ◽  
Pleiotropic Function

Adipose tissue, besides being an important energetic storage, is also a source of cytokines and hormones which act in a paracrine, autocrine and especially endocrine manner, influencing the cardiometabolic axis. Adipokines are a group of mediators with pleiotropic function, that are involved in many physiological processes, so that a disregulation in their secretion can lead to multiple pathological conditions. In this review our aim was to clarify the role of adipokines in the pathogenesis of atherosclerosis, especially in coronary artery disease, and based on current scientific evidence, to analyze the therapeutic and behavioral strategies that are so far available.

scholarly journals Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans

2010 ◽  
Vol 76 (3) ◽  
pp. 662-676 ◽  
Author(s):  
Gui Shen ◽  
Amy Whittington ◽  
Kejing Song ◽  
Ping Wang
Keyword(s):  
Cryptococcus Neoformans ◽  
Pleiotropic Function

scholarly journals Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

Nature ◽  
2006 ◽  
Vol 445 (7125) ◽  
pp. 324-327 ◽  
Author(s):  
J. P. J. Saeij ◽  
S. Coller ◽  
J. P. Boyle ◽  
M. E. Jerome ◽  
M. W. White ◽  
...  
Keyword(s):  
Gene Expression ◽  
Host Gene ◽  
Host Gene Expression ◽  
Kinase Homologue

scholarly journals A cyclin-dependent protein kinase homologue associated with the basal body domains in the ciliate Tetrahymena thermophila

2002 ◽  
Vol 1591 (1-3) ◽  
pp. 119-128 ◽  
Author(s):  
Hong Zhang ◽  
Xueqin Huang ◽  
Liren Tang ◽  
Qian-Jin Zhang ◽  
Joseph Frankel ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Basal Body ◽  
Tetrahymena Thermophila ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Kinase Homologue

scholarly journals A functional study of all 40 Caenorhabditis elegans insulin-like peptides

2018 ◽  
Vol 293 (43) ◽  
pp. 16912-16922 ◽  
Author(s):  
Shanqing Zheng ◽  
Hilton Chiu ◽  
Jeffrey Boudreau ◽  
Tony Papanicolaou ◽  
William Bendena ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Peptide Ligands ◽  
Peptide Sequence ◽  
Functional Study ◽  
C Elegans ◽  
Multiple Phenotypes ◽  
Dauer Formation ◽  
Pleiotropic Function

The human genome encodes 10 insulin-like genes, whereas the Caenorhabditis elegans genome remarkably encodes 40 insulin-like genes. Knockout strategies to determine the roles of all the insulin/insulin-like peptide ligands (INS) in C. elegans has been challenging due to functional redundancy. Here, we individually overexpressed each of the 40 ins genes pan-neuronally, and monitored multiple phenotypes including: L1 arrest life span, neuroblast divisions under L1 arrest, dauer formation, and fat accumulation, as readouts to characterize the functions of each INS in vivo. Of the 40 INS peptides, we found functions for 35 INS peptides and functionally categorized each as agonists, antagonists, or of pleiotropic function. In particular, we found that 9 of 16 agonistic INS peptides shortened L1 arrest life span and promoted neuroblast divisions during L1 arrest. Our study revealed that a subset of β-class INS peptides that contain a distinct F peptide sequence are agonists. Our work is the first to categorize the structures of INS peptides and relate these structures to the functions of all 40 INS peptides in vivo. Our findings will promote the study of insulin function on development, metabolism, and aging-related diseases.

scholarly journals FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.

1993 ◽  
Vol 4 (5) ◽  
pp. 495-510 ◽  
Author(s):  
E A Elion ◽  
B Satterberg ◽  
J E Kranz
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Maximal Activity ◽  
Kinase Assay ◽  
G1 Arrest ◽  
Multicopy Suppressor ◽  
Signal Transduction Cascade ◽  
Kinase Homologue

The mitogen-activated protein (MAP) kinase homologue FUS3 mediates both transcription and G1 arrest in a pheromone-induced signal transduction cascade in Saccharomyces cerevisiae. We report an in vitro kinase assay for FUS3 and its use in identifying candidate substrates. The assay requires catalytically active FUS3 and pheromone induction. STE7, a MAP kinase kinase homologue, is needed for maximal activity. At least seven proteins that specifically associate with FUS3 are phosphorylated in the assay. Many of these substrates are physiologically relevant and are affected by in vivo levels of numerous signal transduction components. One substrate is likely to be the transcription factor STE12. A second is likely to be FAR1, a protein required for G1 arrest. FAR1 was isolated as a multicopy suppressor of a nonarresting fus3 mutant and interacts with FUS3 in a two hybrid system. Consistent with this FAR1 is a good substrate in vitro and generates a FUS3-associated substrate of expected size. These data support a model in which FUS3 mediates transcription and G1 arrest by direct activation of STE12 and FAR1 and phosphorylates many other proteins involved in the response to pheromone.

PKL01, an Ndr kinase homologue in plant, shows tyrosine kinase activity

2012 ◽  
Vol 152 (4) ◽  
pp. 347-353 ◽  
Author(s):  
S. Katayama ◽  
Y. Sugiyama ◽  
N. Hatano ◽  
T. Terachi ◽  
N. Sueyoshi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Tyrosine Kinase Activity ◽  
Kinase Homologue ◽  
Ndr Kinase

A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans

2004 ◽  
Vol 46 (5) ◽  
pp. 247-255 ◽  
Author(s):  
Ping Wang ◽  
Gary M. Cox ◽  
Joseph Heitman
Keyword(s):  
Protein Kinase ◽  
Cryptococcus Neoformans ◽  
Camp Pathway ◽  
Kinase Homologue

scholarly journals Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy

2011 ◽  
Vol 60 (5) ◽  
pp. 625-630 ◽  
Author(s):  
Yukie Shibata ◽  
Miki Kawada-Matsuo ◽  
Yasuhito Shirai ◽  
Naoaki Saito ◽  
Dan Li ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Diacylglycerol Kinase ◽  
Potential Target ◽  
Kinase Homologue
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