High prevalence of chronic kidney disease among patients with diabetic foot: A cross‐sectional study at a tertiary hospital in China

Objetivo: analisar a autopercepção de saúde e os fatores associados dos indivíduos com doença renal crônica em terapia dialítica. Método: estudo transversal, quantitativo, com 42 pacientes assistidos na unidade de nefrologia de um hospital público em Recife/PE, no período de maio a agosto de 2016. Os dados foram coletados por meio de entrevista semiestruturada, analisados por estatística descritiva e inferencial, após aprovação do Comitê de Ética em Pesquisa. Resultados: a autoavaliação de saúde ruim esteve presente em 29 (69%) pacientes, porém sem associação com as características sociodemográficas e clínicas (p<0,05). Conclusão: a alta prevalência da autoavaliação de saúde ruim reflete a necessidade de informações educativas e autocuidado para uma melhor compreensão do estado de saúde e consequente adesão terapêutica.ABSTRACTObjective: to examine health self-perception and associated factors in individuals with chronic kidney disease in dialysis therapy. Method: in this quantitative, cross-sectional study of 42 patients attending the nephrology unit of a public hospital in Recife, Pernambuco, from May to August 2016, data were collected by semistructured interview and analyzed by descriptive and inferential statistics, after approval by the research ethics committee. Results: 29 patients (69%) self-assessed their health as poor, but no association was found with sociodemographic and clinical characteristics (p<0.05). Conclusion: the high prevalence of self-assessed poor health reflects the need for educational information and self-care for a better understanding of health status and consequent adherence to therapy.RESUMENObjetivo: analizar la autopercepción de salud y los factores asociados de los individuos con enfermedad renal crónica en terapia dialítica. Método: estudio transversal, cuantitativo, junto a 42 pacientes asistidos en la unidad de nefrología de un hospital público en Recife/Pernambuco, en el período de mayo a agosto de 2016. Los datos fueron recolectados por medio de entrevista semiestructurada, analizados por estadística descriptiva e inferencial, después de la aprobación del Comité de Ética en Investigación.Resultados: la autoevaluación de mala salud estuvo presente en 29 (69%) pacientes, pero sin asociación con las características sociodemográficas y clínicas (p <0,05). Conclusión: la alta prevalencia de la autoevaluación de mala salud refleja la necesidad de informaciones educativas y autocuidado para una mejor comprensión del estado de salud y consecuente adhesión terapéutica.

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Left ventricular global longitudinal strain in chronic kidney disease patients with and without renal replacement therapy: A cross-sectional study

Indian Heart Journal ◽

10.1016/j.ihj.2020.11.074 ◽

2020 ◽

Vol 72 ◽

pp. S26

Author(s):

Ramesh Sankaran ◽

S. Ramalakshmi ◽

Manish Babbu Uppupetai Ganeshbabbu ◽

M. Jayakumar ◽

T.R. Muralidharan ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Renal Replacement Therapy ◽

Kidney Disease ◽

Replacement Therapy ◽

Longitudinal Strain ◽

Global Longitudinal Strain ◽

Cross Sectional Study ◽

Left Ventricular ◽

Sectional Study ◽

Cross Sectional

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Gut Microbiome Composition Remains Stable in Individuals with Diabetes-Related Early to Late Stage Chronic Kidney Disease

Biomedicines ◽

10.3390/biomedicines9010019 ◽

2020 ◽

Vol 9 (1) ◽

pp. 19

Author(s):

Ashani Lecamwasam ◽

Tiffanie M. Nelson ◽

Leni Rivera ◽

Elif I. Ekinci ◽

Richard Saffery ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Relative Abundance ◽

Cross Sectional Study ◽

Early Event ◽

Sectional Study ◽

Cross Sectional ◽

Microbiome Composition ◽

Stool Samples ◽

Late Stages

(1) Background: Individuals with diabetes and chronic kidney disease display gut dysbiosis when compared to healthy controls. However, it is unknown whether there is a change in dysbiosis across the stages of diabetic chronic kidney disease. We investigated a cross-sectional study of patients with early and late diabetes associated chronic kidney disease to identify possible microbial differences between these two groups and across each of the stages of diabetic chronic kidney disease. (2) Methods: This cross-sectional study recruited 95 adults. DNA extracted from collected stool samples were used for 16S rRNA sequencing to identify the bacterial community in the gut. (3) Results: The phylum Firmicutes was the most abundant and its mean relative abundance was similar in the early and late chronic kidney disease group, 45.99 ± 0.58% and 49.39 ± 0.55%, respectively. The mean relative abundance for family Bacteroidaceae, was also similar in the early and late group, 29.15 ± 2.02% and 29.16 ± 1.70%, respectively. The lower abundance of Prevotellaceae remained similar across both the early 3.87 ± 1.66% and late 3.36 ± 0.98% diabetic chronic kidney disease groups. (4) Conclusions: The data arising from our cohort of individuals with diabetes associated chronic kidney disease show a predominance of phyla Firmicutes and Bacteroidetes. The families Ruminococcaceae and Bacteroidaceae represent the highest abundance, while the beneficial Prevotellaceae family were reduced in abundance. The most interesting observation is that the relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting that this is an early event in the development of diabetes associated chronic kidney disease. We hypothesise that the dysbiotic microbiome acquired during the early stages of diabetic chronic kidney disease remains relatively stable and is only one of many risk factors that influence progressive kidney dysfunction.

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