Functional dyspepsia susceptibility is associated with TGFB1 gene polymorphisms (RS4803455, RS1800469) in H pylori ‐negative Chinese population

2019 ◽  
Vol 31 (10) ◽  
Author(s):  
Cynthia K. Y. Cheung ◽  
Lin Lin Lan ◽  
Yawen Chan ◽  
Kay Yuen ◽  
Pui Kuan Cheong ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
H Pylori ◽  
Tgfb1 Gene

H. pylori Genotypes and Cytokine Gene Polymorphisms Influence the Development of Gastric Intestinal Metaplasia in a Chinese Population

2006 ◽  
Vol 101 (4) ◽  
pp. 714-720 ◽  
Author(s):  
Wai K Leung ◽  
Martin CW Chan ◽  
Ka-Fai To ◽  
Ellen PS Man ◽  
Enders KW Ng ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Cytokine Gene ◽  
Gastric Intestinal Metaplasia ◽  
Cytokine Gene Polymorphisms ◽  
H Pylori

scholarly journals Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Zhijing Xue ◽  
Yuanhai You ◽  
Lihua He ◽  
Yanan Gong ◽  
Lu Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Amino Acid ◽  
Chinese Population ◽  
Statistical Difference ◽  
Variable Region ◽  
Repeat Region ◽  
Geographical Regions ◽  
H Pylori ◽  
Epiya Motifs

Abstract Background The cytotoxin-associated gene A (cagA) is one of the most important virulence factors of Helicobacter pylori (H. pylori). There is a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the C-terminal of CagA protein. This repeat region is thought to play an important role in the pathogenesis of gastrointestinal diseases. The aim of this study was to investigate the diversity of cagA 3′ variable region and the amino acid polymorphisms in the EPIYA segments of the CagA C-terminal region of H. pylori, and their association with gastroduodenal diseases. Methods A total of 515 H. pylori strains from patients in 14 different geographical regions of China were collected. The genomic DNA from each strain was extracted and the cagA 3′ variable region was amplified by polymerase chain reaction (PCR). The PCR products were sequenced and analyzed using MEGA 7.0 software. Results A total of 503 (97.7%) H. pylori strains were cagA-positive and 1,587 EPIYA motifs were identified, including 12 types of EPIYA or EPIYA-like sequences. In addition to the four reported major segments, several rare segments (e.g., B′, B″ and D′) were defined and 20 different sequence types (e.g., ABD, ABC) were found in our study. A total of 481 (95.6%) strains carried the East Asian type CagA, and the ABD subtypes were most prevalent (82.1%). Only 22 strains carried the Western type CagA, which included AC, ABC, ABCC and ABCCCC subtypes. The CagA-ABD subtype had statistical difference in different geographical regions (P = 0.006). There were seven amino acid polymorphisms in the sequences surrounding the EPIYA motifs, among which amino acids 893 and 894 had a statistical difference with gastric cancer (P = 0.004). Conclusions In this study, 503 CagA sequences were studied and analyzed in depth. In Chinese population, most H. pylori strains were of the CagA-ABD subtype and its presence was associated with gastroduodenal diseases. Amino acid polymorphisms at residues 893 and 894 flanking the EPIYA motifs had a statistically significant association with gastric cancer.

Association between AMPKα1 gene polymorphisms and gestational diabetes in the Chinese population: a case‐control study

2021 ◽  
Author(s):  
Mengzhu Guo ◽  
Qingwen Ren ◽  
Feifei Yang ◽  
Tianbi Han ◽  
Wenqiong Du ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

NF1 and PTEN gene polymorphisms and the susceptibility to soft tissue sarcomas in a Chinese population: A case-control study

2021 ◽  
pp. 104603
Author(s):  
Peng Zhang ◽  
Jinyan Liu ◽  
Xinling Li ◽  
Min Gao ◽  
Feifei Feng ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Soft Tissue Sarcomas ◽  
Case Control ◽  
Pten Gene ◽  
Control Study

scholarly journals The Association of Mitofusion-2 Gene Polymorphisms with Susceptibility of Essential Hypertension in Northern Han Chinese Population

2016 ◽  
Vol 13 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Mei Li ◽  
Bei Zhang ◽  
Chuang Li ◽  
Jielin Liu ◽  
Ya Liu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

Association of TNF-α-3959T/C Gene Polymorphisms in the Chinese Population with Intracranial Aneurysms

2017 ◽  
Vol 63 (3-4) ◽  
pp. 349-354 ◽  
Author(s):  
Juntao Hu ◽  
Jie Luo ◽  
Hui Wang ◽  
Chaojia Wang ◽  
Xiaodong Sun ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Population ◽  
Intracranial Aneurysms ◽  
Tnf Α

The association of interleukin-16 gene polymorphisms with IL-16 serum levels and risk of nasopharyngeal carcinoma in a Chinese population

Tumor Biology ◽  
2013 ◽  
Vol 35 (3) ◽  
pp. 1917-1924 ◽  
Author(s):  
Xue Qin ◽  
Qiliu Peng ◽  
Xiaoxia Lao ◽  
Zhiping Chen ◽  
Yu Lu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Serum Levels

Association of Klotho and interleukin 6 gene polymorphisms with aging in Han Chinese population

2014 ◽  
Vol 18 (10) ◽  
pp. 900-904 ◽  
Author(s):  
W. -G. Zhang ◽  
X. -J. Bai ◽  
D. -P. Chen ◽  
Y. Lv ◽  
X. -F. Sun ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Association of XRCC1 gene polymorphisms with idiopathic azoospermia in a Chinese population

2007 ◽  
Vol 9 (6) ◽  
pp. 781-786 ◽  
Author(s):  
Ai-Hua Gu ◽  
Jie Liang ◽  
Ning-Xia Lu ◽  
Bin Wu ◽  
Yan-Kai Xia ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Population ◽  
Xrcc1 Gene

scholarly journals Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population

Medicine ◽  
2017 ◽  
Vol 96 (33) ◽  
pp. e7481 ◽  
Author(s):  
Lu-Bing Liu ◽  
Tong Liu ◽  
Fu-Ze Xin
Keyword(s):  
Colorectal Cancer ◽  
Multidrug Resistance ◽  
Gene Polymorphisms ◽  
Chinese Population
Sign in / Sign up

Export Citation Format

Share Document