MicroRNA‐203 mediates P. gingivalis LPS‐induced inflammation and differentiation of periodontal ligament cells

Oral Diseases ◽  
2022 ◽  
Author(s):  
Yang Yang ◽  
Dongping Ren ◽  
Duo Zhao ◽  
Bo Zhang ◽  
Rui Ye
Keyword(s):  
Periodontal Ligament ◽  
Periodontal Ligament Cells

Hypoxia stimulates collagen hydroxylation in gingival fibroblasts and periodontal ligament cells

2021 ◽  
Author(s):  
Chiaki Morimoto ◽  
Masahide Takedachi ◽  
Kohsuke Kawasaki ◽  
Junpei Shimomura ◽  
Mari Murata ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Periodontal Ligament Cells ◽  
Gingival Fibroblasts

Genome‐Wide DNA (hydroxy)methylation reveals the individual epigenetic landscape importance on osteogenic phenotype acquisition in periodontal ligament cells

2021 ◽  
Author(s):  
Rogério S. Ferreira ◽  
Rahyza I. F. Assis ◽  
Geórgia da S. Feltran ◽  
Iasmin Caroline do Rosário Palma ◽  
Beatriz G. Françoso ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Periodontal Ligament Cells ◽  
Epigenetic Landscape ◽  
Genome Wide ◽  
The Individual

GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells

2016 ◽  
Vol 118 (4) ◽  
pp. 699-708
Author(s):  
Shinichiro Yoshida ◽  
Naohide Yamamoto ◽  
Naohisa Wada ◽  
Atsushi Tomokiyo ◽  
Daigaku Hasegawa ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Inflammatory Cytokines ◽  
Periodontal Ligament ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells ◽  
Pro Inflammatory Cytokines

scholarly journals The Cytolethal Distending Toxin Induces Receptor Activator of NF-κB Ligand Expression in Human Gingival Fibroblasts and Periodontal Ligament Cells

2005 ◽  
Vol 73 (1) ◽  
pp. 342-351 ◽  
Author(s):  
G. N. Belibasakis ◽  
A. Johansson ◽  
Y. Wang ◽  
C. Chen ◽  
S. Kalfas ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Mrna Expression ◽  
Periodontal Ligament ◽  
Aggressive Periodontitis ◽  
Periodontal Ligament Cells ◽  
Cytolethal Distending Toxin ◽  
Gingival Fibroblasts ◽  
Wild Type ◽  
Rankl Expression ◽  
Receptor Activator

ABSTRACT Actinobacillus actinomycetemcomitans is associated with localized aggressive periodontitis, a disease characterized by rapid loss of the alveolar bone surrounding the teeth. Receptor activator of NF-κB Ligand (RANKL) and osteoprotegerin (OPG) are two molecules that regulate osteoclast formation and bone resorption. RANKL induces osteoclast differentiation and activation, whereas OPG blocks this process by acting as a decoy receptor for RANKL. The purpose of this study was to investigate the effect of A. actinomycetemcomitans on the expression of RANKL and OPG in human gingival fibroblasts and periodontal ligament cells. RANKL mRNA expression was induced in both cell types challenged by A. actinomycetemcomitans extract, whereas OPG mRNA expression remained unaffected. Cell surface RANKL protein was also induced by A. actinomycetemcomitans, whereas there was no change in OPG protein secretion. A cytolethal distending toxin (Cdt) gene-knockout strain of A. actinomycetemcomitans did not induce RANKL expression, in contrast to its wild-type strain. Purified Cdt from Haemophilus ducreyi alone, or in combination with extract from the A. actinomycetemcomitans cdt mutant strain, induced RANKL expression. Pretreatment of A. actinomycetemcomitans wild-type extract with Cdt antiserum abolished RANKL expression. In conclusion, A. actinomycetemcomitans induces RANKL expression in periodontal connective tissue cells. Cdt is crucial for this induction and may therefore be involved in the pathological bone resorption during the process of localized aggressive periodontitis.

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