Choroidal vascularity index changes during the Valsalva manoeuvre in healthy volunteers

2021 ◽  
Author(s):  
Mehmet Orkun Sevik ◽  
Furkan Çam ◽  
Aslan Aykut ◽  
Volkan Dericioğlu ◽  
Özlem Şahin
Keyword(s):  
Healthy Volunteers ◽  
Valsalva Manoeuvre ◽  
Index Changes

scholarly journals Measurement of the retinal venous pressure with a new instrument in healthy subjects

2021 ◽  
Author(s):  
Richard Stodtmeister ◽  
Emilie Wetzk ◽  
Robert Herber ◽  
Karin R. Pillunat ◽  
Lutz E. Pillunat
Keyword(s):  
Healthy Volunteers ◽  
Contact Lens ◽  
Airway Pressure ◽  
Venous Pressure ◽  
Intraclass Correlation ◽  
Valsalva Manoeuvre ◽  
Cross Sectional ◽  
Retinal Venous Pressure ◽  
New Instrument ◽  
Venous Pulsation

Abstract Background The retinal venous pressure (RVP) is a determining factor for the blood supply of the retina as well as the optic nerve head and until recently has been measured by contact lens dynamometry (CLD). A new method has been developed, potentially offering better acceptance. The applicability and the results of both methods were compared. Methods The type of this study is cross sectional. The subjects were 36 healthy volunteers, age 26 ± 5 years (mean ± s). Tonometry: rebound tonometer (RT) (iCare). The measurements were performed during an increase in airway pressure of 20 mmHg (Valsalva manoeuvre). Principle of RVP measurement: the central retinal vein (CRV) is observed during an increase of intraocular pressure (IOP) and at the start of pulsation, which corresponds with the RVP. Two different instruments for the IOP enhancement where used: contact lens dynamometry and the new instrument, IOPstim. Principle: a deflated balloon of 8 mm diameter—placed on the sclera laterally of the cornea—is filled with air. As soon as a venous pulsation occurs, filling is stopped and the IOP is measured, equalling the RVP. Examination procedure: randomization of the sequence: CLD or IOPstim, IOP, mydriasis, IOP three single measurements (SM) of the IOP with RT or of the pressure increase with CLD at an airway pressure of 20 mmHg, 5 min break, IOP, and three SM using the second method at equal pressure (20 mmHg). Results Spontaneous pulsation of the CRV was present in all 36 subjects. Pressures are given in mmHg. IOP in mydriasis 15.6 ± 3.3 (m ± s). Median RVP (MRVP)) of the three SM: CLD/IOPstim, 37.7 ± 5.2/24.7 ± 4.8 (t test: p < 0.001). Range of SM: 3.2 ± 1.8/2.9 ± 1.3 (t test: p = 0.36). Intraclass correlation coefficient (ICC) of SM: 0.88/0.83. ANOVA in SM: p = 0.48/0.08. MRVP CLD minus MRVP IOPstim: 13.0 ± 5.6. Ratio MRVP CLD/MRVP IOPstim: 1.56 ± 3.1. Cooperation and agreeability were slightly better with the IOPstim. Conclusion This first study with the IOPstim in humans was deliberately performed in healthy volunteers using Valsalva conditions. As demonstrated by ICC and ANOVA, reproducible SM can be obtained by both methods and the range of the SM does not differ greatly. The higher MRVP in CLD could be explained by the different directions of the force vectors.

Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers

1999 ◽  
Vol 13 (6) ◽  
pp. 1230 ◽  
Author(s):  
B Schmekel ◽  
I Rydberg ◽  
B Norlander ◽  
K.n Sjöswärd ◽  
J Ahlner ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Stereoselective Pharmacokinetics

Estimation of 15O PET in healthy volunteers with automated ROI analysis by FineSRT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S673-S673
Author(s):  
Ryo Takeuchi ◽  
Keiichi Matsumoto ◽  
Setsu Sakamoto ◽  
Yuhji Nakamoto ◽  
Michio Senda
Keyword(s):  
Healthy Volunteers
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