scholarly journals Affordable oral healthcare: Dental biofilm disruption using chloroplast made enzymes with chewing gum delivery

2021 ◽  
Author(s):  
R. Singh ◽  
Z. Ren ◽  
Y. Shi ◽  
S. Lin ◽  
K‐C. Kwon ◽  
...  
Keyword(s):  
Chewing Gum ◽  
Dental Biofilm ◽  
Biofilm Disruption

Effects of Octenidine on the Formation and Disruption of Dental Biofilms: An Exploratory In Situ Study in Healthy Subjects

2021 ◽  
pp. 002203452199904
Author(s):  
B. Reda ◽  
J. Dudek ◽  
M. Martínez-Hernández ◽  
M. Hannig
Keyword(s):  
Biofilm Formation ◽  
Healthy Subjects ◽  
Periodontal Diseases ◽  
Oral Diseases ◽  
Biofilm Thickness ◽  
Dental Biofilm ◽  
Octenidine Dihydrochloride ◽  
Biofilm Disruption ◽  
Low Sensitivity

Dental biofilms are highly structured, complex multispecies communities that, if left untreated, lead to severe oral complications such as caries and periodontal diseases. Therefore, antibiofilm agents are often recommended for both preventive and therapeutic measures. However, biofilm management can be challenging due to the low sensitivity of biofilms to antimicrobial treatments. Octenidine dihydrochloride (OCT) is a highly effective antibacterial agent. Because the OCT antibiofilm efficacy has not been studied in situ, this exploratory crossover study aimed to evaluate the effects of OCT mouth rinsing on biofilm formation and on the disruption of mature biofilms. Moreover, a comparison to the gold-standard chlorhexidine (CHX) was conducted. The biofilms were formed intraorally by 5 healthy volunteers on enamel specimens fixed to acrylic splints. For biofilm formation analysis, OCT, CHX, or water rinses were applied for 30 s every 12 h. The samples evaluation took place at 24-and 48-h time points. For biofilm disruption analysis, sample assessment was performed before and directly after the first OCT or CHX rinse on 48-h mature biofilms. A second rinse was carried out 12 h later. The last assessment was applied to 72-h mature biofilms. The biofilms were analyzed by fluorescence microscopy and transmission electron microscopy. The results showed OCT significantly reducing biofilm formation and bacterial vitality in situ. Simultaneously, the biofilm thickness was strongly decreased. Moreover, a single application of OCT to a 48-h mature biofilm induced substantial biofilm disruption. In addition, the efficacy of OCT compared favorably to CHX. These findings show that OCT rinses prevent biofilm formation and disrupt preexisting mature biofilms formed by healthy subjects. This work suggests that OCT might be used for dental biofilm management as a part of the medical treatment of oral diseases. Future studies with a larger subject heterogeneity and number are needed to confirm the observed OCT effects.

scholarly journals The effectiveness of apple, sugar-free chewing gum and Rolly Brush® in the reduction of plaque index: crossover randomized clinical trial

2021 ◽  
Vol 29 (1) ◽  
Author(s):  
Luana Moreira ◽  
Mariana Pontes ◽  
Egina Brum ◽  
Larissa Silva ◽  
Dhelfeson Douglas De Oliveira ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dental Plaque ◽  
Periodontal Diseases ◽  
The Self ◽  
The Other ◽  
Plaque Index ◽  
Chewing Gum ◽  
Dental Biofilm ◽  
Index Evaluation ◽  
Dental Plaque Index

Background: The implementation of the self-cleaning practice is of fundamental importance for the maintenance of oral health and to remove the human dental biofilm which is considered the main etiological factor for the development of caries and periodontal diseases.                      Objective: This study aimed to evaluate the use of chewing gum, Rolly Brush® and apples as forms of mechanical control and removal of the dental biofilm in the absence of brushing. Materials and Methods: Eighteen volunteers were submitted to plaque index evaluation after a period of 24 hours of no oral hygiene. Then, they would use one of the methods: chewing gum, Rolly Brush®, apple or tooth brushing, chosen by a draw, for one minute, and then, plaque index was evaluated again. This stage was repeated until all participants were submitted to all selected methods, in periods of 24 hours each.   Results: Dental brushing was more effective when compared to each of the other methods applied and there was a statistically significant reduction of dental plaque index after apllying all methods of cleaning in all groups. Conclusion: Chewing gum, Rolly Brush® and apple may be used as auxiliary to dental brushing or when such method is impossible to be performed. Clinicaltrials.gov: number of protocol NCT 03.601.585.

What Can Be Done With Baling Wire and Chewing Gum?

2007 ◽  
Author(s):  
Judge Karla Fultz ◽  
Todd Beveridge
Keyword(s):  
Chewing Gum

Effect of Chewing Gum on Bowel Motility in Women Undergoing Post-Operative Cesarean Section

2018 ◽  
Vol 3 (06) ◽  
Author(s):  
Dr.Randa Mohammed AboBaker
Keyword(s):  
Cesarean Section ◽  
Hospital Stay ◽  
Demographic Data ◽  
Length Of Hospital Stay ◽  
Chewing Gum ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Bowel Motility ◽  
Gum Chewing ◽  
Significant Difference

Postoperative Ileus (POI) is one of the most common problems after obstetrics, gynecologic and abdominal surgeries. Sham feeding, such as gum chewing, accelerates the return of bowel function and the length of hospital stay. The present study aims to evaluate the effect of chewing gum on bowel motility in women undergoing post-operative cesarean section. Intervention study was used at the Postpartum Department of Maternity and Children Hospital, KSA. A randomized controlled clinical trial research design. Through a convenience technique, 80 post Caesarian Section (CS) women were included in the study. Data were collected through three tools: Tool (I): Socio-demographic data and reproductive history interview schedule. Tool (II): Postoperative Assessment Sheet. Tool (III): Outcomes of gum chewing and the length of hospital stay.  Method: subjects were assigned randomly into two groups of (40) the experimental and (40) the control. Subjects in the study group were asked to chew two pieces of sugarless gum for 30 min/three times daily in the morning, noon, and evening immediately after recovery from anesthesia and in Postpartum Department; while subjects in the control group followed the hospital routine care. Each woman in both groups was tested abdominally using a stethoscope to auscultate the bowel sounds and asked to report immediately the time of either passing flatus or stool. Results: illustrated that a highly statistically significant difference was observed between the two groups concerning their gum chewing outcomes. Where, P = 0.000. The study concluded that gum chewing is safe, well tolerated and appears to be effective in reducing the incidence and consequences of POI following CS.

Swallowing Rehabilitation Using Chewing Gum Containing Capsaicin.

2002 ◽  
Vol 53 (3) ◽  
pp. 285-288 ◽  
Author(s):  
Hirohito Umeno ◽  
Sachiyo Hamakawa ◽  
Kyujirou Gondoh ◽  
Hidetaka Shirouzu ◽  
Yoshikazu Yoshida ◽  
...  
Keyword(s):  
Chewing Gum ◽  
Swallowing Rehabilitation

Study of technological characteristics of the Health in gum® base for chewing gum

2020 ◽  
pp. 18-21
Author(s):  
E. Blynskaya ◽  
S. Tishkov ◽  
V. Bueva ◽  
K. Alekseev ◽  
V. Alekseev ◽  
...  
Keyword(s):  
Dosage Form ◽  
Patent Protection ◽  
Chewing Gum ◽  
Direct Compression ◽  
Technological Properties ◽  
Technological Characteristics ◽  
Chewing Gums

Medicated chewing gum is a convenient dosage form that allows to expand the range of medicines, ensure adherence of patients to the treatment and extend patent protection for well-known names of medicines. This article describes the technological properties of the Health in Gum® chewing gum base, which provides medicinal chewing gums with minimal addition of excipients by direct compression.

ASPECTOS ANTROPOLÓGICOS, BIOQUÍMICOS, MICROBIOLÓGICOS E CLÍNICOS DO CÁLCULO DENTÁRIO: UMA REVISÃO DA LITERATURA

2018 ◽  
Author(s):  
Raphael Hirata Júnior
Keyword(s):  
Oral Cavity ◽  
Oral Hygiene ◽  
Preventive Measures ◽  
Dental Calculus ◽  
Dental Biofilm

Resumo: O cálculo dentário é uma estrutura calcificada a partir do biofilme dentário (placa bacteriana) que, após o seu estabelecimento, é de difícil remoção e constitui um mecanismo de patogenicidade importante em diversas situações patológicas da cavidade oral por estar sempre coberto por uma camada viável de biofilme não mineralizada. A presente revisão de literatura releva a importância dos biofilmes calcificados nos contextos de doença, seus aspectos clínicos e microbiológicos em tempos anciães e contemporâneos, e sobre as medidas terapêuticas e preventivas. Apesar de todo conhecimento gerado sobre as doenças da cavidade oral, ainda são limitadas as abordagens clínicas a respeito dos mecanismos de controle dos cálculos dentários.Abstract: Dental calculus is a calcified structure from the dental biofilm (plaque), which, after its establishment, is difficult to remove and constitutes an important mechanism of pathogenicity in various pathological situations of the oral cavity because it is always covered by a viable layer of non-mineralized biofilm. The present literature highlights the importance of calcified biofilms in disease contexts, clinical and microbiological of dental calculus aspects in ancient and contemporary eras, and in therapeutic and preventive measures. Despite all the knowledge generated about the diseases of the oral cavity, the clinical approaches regarding the mechanisms of control of dental calculus still need investigations.Palavras Chave: Cálculo dentário, Calcificação do biofilme, Higiene oralKey words: Dental calculus, Biofilm calcification, Oral hygiene

CHEWING GUM

BMJ ◽  
1913 ◽  
Vol 1 (2721) ◽  
pp. 416-416 ◽  
Author(s):  
H. Kerr
Keyword(s):  
Chewing Gum

scholarly journals The comparative effect of propolis in two different vehicles; mouthwash and chewing-gum on plaque accumulation and gingival inflammation

2015 ◽  
Vol 09 (02) ◽  
pp. 272-276 ◽  
Author(s):  
Nuray Ercan ◽  
Ebru Olgun Erdemir ◽  
Serdar Yucel Ozkan ◽  
Meltem Karsiyaka Hendek
Keyword(s):  
Health Care ◽  
Clinical Study ◽  
Oral Health ◽  
Oral Hygiene ◽  
Chewing Gum ◽  
Gingival Inflammation ◽  
Comparative Effect ◽  
Gingival Health ◽  
General Chemical ◽  
Single Blind

ABSTRACT Objective: In general, chemical plaque agents have been used in mouthwashes, gels, and dentifrices. In some situations, application of mouthwashes and dentifrices can be difficult. Therefore, different approaches for oral health-care have been needed. The aim of this study was to evaluate the effect of propolis chewing-gum compared to propolis-containing mouthwash on gingival inflammation and plaque accumulation on patients that refrained from daily oral hygiene procedures for 5 days. Materials and Methods: 10 college students with systemically healthy and very good oral hygiene and gingival health were included in this randomized, single-blind, crossover 5-day plaque regrowth with a 3-day washout period clinical study. After plaque scores were reduced to zero, participants were asked to refrain from oral hygiene procedures and allocated to either propolis mouthwash or chewing-gum group. Chewing-gum was performed after meals 3 times a day for 20 min mouthwash group was instructed to rinse mouthwash 2 times a day for 1 min. On day 5, the clinical periodontal measurements containing plaque and gingival indexes were taken from the participants. Results: The both plaque and gingival indexes of propolis mouthwash group were significantly lower than that of the propolis chewing-gum group (P = 0.005). Conclusion: It was demonstrated that the propolis mouthwash was more effective than the propolis chewing gum on the plaque inhibition and the gingival inflammation.

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