scholarly journals HUMIDIFIER LUNG: CHARACTERIZATION OF FEATURES AND COMPARISON TO OTHER HYPERSENSITIVITY PNEUMONITIS PHENOTYPES

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 279-279
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Humidifier Lung

scholarly journals Features of humidifier lung and comparison with summer‐type hypersensitivity pneumonitis

Respirology ◽  
2021 ◽  
Author(s):  
Masafumi Shimoda ◽  
Kozo Morimoto ◽  
Yoshiaki Tanaka ◽  
Koji Furuuchi ◽  
Takeshi Osawa ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Humidifier Lung

scholarly journals Establishment and Characterization of a Novel Fibroblastic Cell Line (SCI13D) Derived from the Broncho-Alveolar Lavage of a Patient with Fibrotic Hypersensitivity Pneumonitis

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1193
Author(s):  
Paolo Giannoni ◽  
Marco Grosso ◽  
Giuseppina Fugazza ◽  
Mario Nizzari ◽  
Maria Cristina Capra ◽  
...  
Keyword(s):  
Cell Line ◽  
Hypersensitivity Pneumonitis ◽  
Type I Collagen ◽  
Smooth Muscle Actin ◽  
Usual Interstitial Pneumonia ◽  
Type I ◽  
Fibroblastic Cell ◽  
Primary Fibroblasts

Hypersensitivity pneumonitis (HP) is a diffuse interstitial lung disease (ILD) caused by the inhalation of a variety of antigens in susceptible individuals. Patients with fibrotic HP (fHP) may show histopathological and radiological manifestations similar to patients with idiopathic pulmonary fibrosis (usual interstitial pneumonia-like pattern of fibrosis) that are associated with a worse prognosis. We describe here the establishment and characterization of a fibroblastic cell line derived from the broncho-alveolar lavage (BAL) of a patient with fHP, a 53 year old man who presented at our Pneumology Unit with cough and dyspnea. The fHP diagnosis was based on international criteria and multidisciplinary discussion. Primary fibroblasts were expanded in vitro until passage 36. These fibroblasts displayed morpho/phenotypical features of myofibroblasts, showing high positivity for α-smooth muscle actin, type I collagen, and fibronectin as determined by quantitative RT-PCR and cyto-fluorographic analysis. Cytogenetic analyses further evidenced trisomy of chromosome 10, which interestingly harbors the FGF2R gene. To our knowledge, this is the first fibroblastic cell line derived from an fHP patient and might, therefore, represent a suitable tool to model the disease in vitro. We preliminarily assessed here the activity of pirfenidone, further demonstrating a consistent inhibition of cells growth by this antifibrotic drug.

Humidifier Lung: Hypersensitivity Pneumonitis Related to Thermotolerant Bacterial Aerosols

CHEST Journal ◽  
1976 ◽  
Vol 69 (2) ◽  
pp. 294-296 ◽  
Author(s):  
Peter F. Kohler ◽  
Gary Gross ◽  
John Salvaggio ◽  
June Hawkins
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Bacterial Aerosols ◽  
Humidifier Lung

Clinical and radiological characteristics of ultrasonic humidifier lung and summer-type hypersensitivity pneumonitis

2020 ◽  
Vol 174 ◽  
pp. 106196
Author(s):  
Susumu Sakamoto ◽  
Marie Furukawa ◽  
Hiroshige Shimizu ◽  
Muneyuki Sekiya ◽  
Shion Miyoshi ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Ultrasonic Humidifier ◽  
Humidifier Lung

Hypersensitivity pneumonitis

2020 ◽  
pp. 4244-4256
Author(s):  
S. J. Bourke ◽  
G.P. Spickett
Keyword(s):  
Lung Fibrosis ◽  
Hypersensitivity Pneumonitis ◽  
Granulomatous Inflammation ◽  
Working Fluid ◽  
Thermophilic Actinomycetes ◽  
Diverse Range ◽  
Immune Mediated ◽  
Insidious Development ◽  
Bird Fancier’S Lung ◽  
Humidifier Lung

Hypersensitivity pneumonitis is an immune-mediated lung disease in which the repeated inhalation of certain antigens provokes a hypersensitivity response, with granulomatous inflammation in the distal bronchioles and alveoli of susceptible people. A diverse range of antigens including bacteria (Thermophilic actinomycetes), fungi (Trichosporon cutaneum), animal proteins (bird antigens), mycobacteria, and chemicals may cause the disease. The commonest forms are bird fancier’s lung, farmer’s lung, humidifier lung, and metal-working fluid pneumonitis. In some cases no antigen is identified. Acute disease is characterized by recurrent episodes of breathlessness, cough, fevers, malaise, and flu-like symptoms occurring 4–8 hours after antigen exposure. Fever and basal crackles are the main physical signs. Chronic disease is characterized by the insidious development of dyspnoea and persistent pneumonitis, sometimes progressing to lung fibrosis. Clinical features are similar to those of other varieties of pulmonary fibrosis, but clubbing is uncommon.

Humidifier lung: hypersensitivity pneumonitis related to thermotolerant bacterial aerosols

CHEST Journal ◽  
1976 ◽  
Vol 69 (2) ◽  
pp. 294-296 ◽  
Author(s):  
P. F. Kohler ◽  
G. Gross ◽  
J. Salvaggio ◽  
J. Hawkins
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Bacterial Aerosols ◽  
Humidifier Lung

scholarly journals Humidifier lung induced by endotoxin and various pathogens: Characteristic differences from other phenotypes of hypersensitivity pneumonitis

2020 ◽  
Vol 31 ◽  
pp. 101267
Author(s):  
Masafumi Shimoda ◽  
Kozo Morimoto ◽  
Yoshiaki Tanaka ◽  
Ohta Ken ◽  
Kozo Yoshimori
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Humidifier Lung

scholarly journals Antigen avoidance and outcome of nonfibrotic and fibrotic hypersensitivity pneumonitis

2021 ◽  
pp. 00474-2021
Author(s):  
Takashi Nishida ◽  
Eriko Kawate ◽  
Takashi Ishiguro ◽  
Tetsu Kanauchi ◽  
Yoshihiko Shimizu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Mortality Rate ◽  
Bronchoalveolar Lavage ◽  
Medical Records ◽  
Poor Prognosis ◽  
Hypersensitivity Pneumonitis ◽  
First Line ◽  
Humidifier Lung ◽  
Related Mortality

BackgroundHypersensitivity pneumonitis (HP) is classified into nonfibrotic and fibrotic phenotypes. Patients with nonfibrotic HP often experience recurrence and develop fibrosis, whereas those with fibrotic HP have a poor prognosis. Although antigen avoidance has long been the first line of treatment for HP, its impact on prognosis has been poorly reported.MethodsMedical records of 121 patients with HP diagnosed by new diagnostic criteria of ATS/JRS/ALAT guidelines and treated at our institution in Saitama, Japan, were retrospectively analysed. HP was classified into nonfibrotic and fibrotic phenotypes and 6 HP subtypes: summer-type, bird-related, home-related, and occupational HP, humidifier lung, and hot tub lung. Achievement of reduced exposure to inciting agents was divided into complete antigen avoidance (CAA) and incomplete antigen avoidance (IAA) by HP subtype.ResultsOf the 74 patients with nonfibrotic HP, 30 achieved CAA and experienced no recurrence or development of fibrosis. In the remaining 44 patients with IAA, 24 (54.5%) experienced recurrence and/or development of fibrosis. The all-cause 5-year mortality rate in the 47 patients with fibrotic HP was 47.8%. Negative prognostic factors of HP-related mortality in these patients were <50% lymphocytes in bronchoalveolar lavage (BAL) and honeycombing. Multivariate analysis showed a tendency for IAA to be related to poorer survival (hazard ratio: 3.452, 95% CI, 0.964-12.359, p=0.057).ConclusionsIn the patients with nonfibrotic HP, CAA resulted in no recurrence or development of fibrosis and longer survival. In the patients with fibrotic HP, <50% lymphocytes in BAL and honeycombing were negative prognostic factors for mortality.

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