P9‐25: Usefulness of comprehensive evaluation of spirometry and impulse oscillometry with airway reversibility in the diagnosis of cough variant asthma, bronchial asthma, and asthma‐COPD overlap

Abstract Background: Bronchial asthma (BA) has different phenotypes, and it requires a clinically effective subtype classification system. The impulse oscillometry system (IOS) is a novel device used in respiratory functional tests. However, its efficacy has not been validated. Therefore, this study aimed to assess the relationship between BA and the IOS parameters, and the difference in the therapeutic effects of inhaled corticosteroids (ICSs) among the subtype classifications was evaluated using the IOS.Methods: The following ICSs were randomly prescribed in daily medical care: coarse-particle ICS (fluticasone propionate [FP]), fine-particle ICS (mometasone furoate [MF]), and moderate-particle ICS (budesonide [BUD]). The treatment effects were assessed using the Asthma Health Questionnaire (AHQ) and the Asthma Control Test (ACT), and were compared among the three subtypes (central predominant, peripheral predominant, and resistless) using the IOS.Results: In the central predominant type, the AHQ score of the MF group was significantly higher than that of the FP and BUD groups. In the peripheral predominant type, the MF group had a significantly lower AHQ than the FP group. In the resistless type, no significant difference was observed in the AHQ scores among the three groups. Moreover, similar results were obtained in the study using ACTConclusions: A strong association was observed between IOS subtype classification and ICS particle size in terms of therapeutic efficiency in BA. This result indicates that the ICS particle size must be identified using the IOS subtype classification before treatment.

Download Full-text

Examinations Of Impulse Oscillometry In The University Students With A History Of Bronchial Asthma

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5673 ◽

2012 ◽

Author(s):

Yoshihito Tanaka ◽

Shingo Takanashi ◽

Akihito Hayashi ◽

Takeshi Morimoto ◽

Kageaki Taima ◽

...

Keyword(s):

University Students ◽

Bronchial Asthma ◽

Impulse Oscillometry ◽

History Of ◽

The University

Download Full-text

THE SITE OF AIRWAY OBSTRUCTION AMONG PATIENTS OF BRONCHIAL ASTHMA: ROLE OF IMPULSE OSCILLOMETRY

CHEST Journal ◽

10.1378/chest.134.4_meetingabstracts.p5004 ◽

2008 ◽

Vol 134 (4) ◽

pp. 5P ◽

Cited By ~ 1

Author(s):

Harmanjit S. Hira ◽

Anshu Singh

Keyword(s):

Airway Obstruction ◽

Bronchial Asthma ◽

Impulse Oscillometry

Download Full-text

Impulse Oscillometry May Be Useful in Evaluation of Bronchiectasis Severity and Prediction of Airway Reversibility.

10.21203/rs.3.rs-445238/v1 ◽

2021 ◽

Author(s):

Cuiyan Tan ◽

Donghai Ma ◽

Kongqiu Wang ◽

Changli Tu ◽

Meizhu Chen ◽

...

Keyword(s):

Airway Resistance ◽

Severe Disease ◽

Peripheral Resistance ◽

Roc Curves ◽

Small Airways ◽

Impulse Oscillometry ◽

Airway Diseases ◽

The Difference ◽

Obstructive Airway Diseases ◽

Airway Reversibility

Abstract BackgroundImpulse oscillometry (IOS) can be used to evaluateairway impedance in patients with obstructive airway diseases. Previous studies have demonstrated that IOS parameters differ betweenbronchiectasis patients and healthy controls. This study aims to explore the usefulness of IOS in assessing disease severity and airway reversibility in bronchiectasis.MethodSeventy-four patients with non-cystic fibrosis bronchiectasis who visited our Respiratory Medicine outpatient clinic were consecutively recruited. Spirometry, plethysmography and IOS tests were performed. Patients were stratified into mild, moderate and severe disease according to Reiff, Bhalla, BSI, FACED, and BRICS scores. Airway reversibility was measured by bronchodilation test (BDT) and the result was classified as positive or negative.. ROC curves of IOS parameters was used to assess the usefulness of IOS parameters in predicting airway reversibility. Correlations between the IOS, spirometric lung function and bronchiectasis severity parameters were analysed.ResultsMany IOS parameters, such as airway resistance at 5Hz (R5), small airways resistance (R5–R20), total airway reactance (X5), resonance frequency (Fres), total airway impedance at 5Hz (Z5), and peripheral resistance (Rp) increased with increased bronchiectasis severity according to the FACED, BSI and Reiff scores. Large airway resistance (R20) and central resistance (Rc) were not significantly different among groups with differentbronchiectasis severity. The difference between R5 and R20 (R5-R20) showed 81.0% sensitivity, and 69.8%specificity in predicting the airway reversibility in bronchiectasis with AUC of 0.794 (95%CI, 0.672-0.915).ConclusionIOS measurements are useful indicators of bronchiectasis severity and may be useful for predicting the airway reversibility.

Download Full-text

A retrospective analysis of usefulness of impulse oscillometry system in the treatment of asthma

10.21203/rs.3.rs-22555/v4 ◽

2020 ◽

Author(s):

Hiroyuki Sugawara ◽

Atsushi Saito ◽

Saori Yokoyama ◽

Kazunori Tsunematsu ◽

Hirofumi Chiba ◽

...

Keyword(s):

Bronchial Asthma ◽

Inhaled Corticosteroids ◽

Therapeutic Effects ◽

Impulse Oscillometry ◽

Asthma Control Test ◽

Subtype Classification ◽

Predominant Type ◽

The Difference ◽

Act Score ◽

The Relationship

Abstract Background: Bronchial asthma (BA) has different phenotypes, and it requires a clinically effective subtype classification system. The impulse oscillometry system (IOS) is an emerging technique device used in respiratory functional tests. However, its efficacy has not been validated. Therefore, this study aimed to assess the relationship between BA and the IOS parameters, and the difference in the therapeutic effects of inhaled corticosteroids (ICSs) among the subtype classifications was evaluated using the IOS.Methods: Of the 245 patients with bronchial asthma who were screened, 108 were enrolled in this study. These patients were divided based on three subtypes according to the IOS result as follows: central predominant type (n = 34), peripheral predominant type (n = 58), and resistless type (n = 16). Then, the following ICSs were randomly prescribed in daily medical care: coarse-particle ICS (fluticasone propionate [FP]), fine-particle ICS (mometasone furoate [MF]), and moderate-particle ICS (budesonide [BUD]). The treatment effects were assessed using the Asthma Health Questionnaire (AHQ) and the Asthma Control Test (ACT) and were compared among the three subtypes.Results: In the central predominant type, the AHQ score of the MF group was significantly higher than that of the FP group (15.4 vs. 3.6, p < 0.01) and the BUD group (15.4 vs. 8.8, p < 0.05); the ACT score of the FP group was significantly higher than that of the MF and BUD groups (24.3 vs. 21.7, 22.3, respectively, p < 0.05) at 4 weeks after treatment. In the peripheral predominant type, the AHQ score of the FP group was significantly higher than that of the MF group (14.1 vs. 3.4, p < 0.05); the ACT score of the FP group was lower than that of the MF and BUD groups (22.8 vs. 24.6, 24.4, respectively, p < 0.01) at 4 weeks after treatment. Conclusions: An association was observed between IOS subtype classification and ICS particle size in terms of therapeutic efficacy in BA. This result indicates that the IOS could be an effective tool in the selection of ICS and the evaluation of the BA phenotype.

Download Full-text