Delayed diagnosis and treatment of secondary syphilis in pancreas‐kidney transplant recipient: Need for increased awareness of sexually transmitted infections in solid organ transplantation

2021 ◽  
Author(s):  
Hayley Crossman ◽  
Elan Guterman ◽  
Monica Fung
Keyword(s):  
Transplant Recipient ◽  
Sexually Transmitted Infections ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Solid Organ Transplantation ◽  
Delayed Diagnosis ◽  
Secondary Syphilis ◽  
Solid Organ ◽  
Sexually Transmitted ◽  
Recipient Need

scholarly journals Klebsiella ozaenaeBacteremia in a Kidney Transplant Recipient

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Shree Kumar ◽  
Talal Alfaadhel ◽  
Meteb M. AlBugami
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Solid Organ Transplantation ◽  
Gastrointestinal Symptoms ◽  
Organ Transplant Recipient ◽  
Solid Organ Transplant Recipient ◽  
Solid Organ ◽  
High Grade Fever ◽  
Short Period

Infections remain a dreadful complication after solid organ transplantation. Almost all microorganisms could cause this complication, including unusual ones. We report a 73-year-old patient, with a history of kidney transplant for 38 years on minimum immunosuppression, who presented with high-grade fever and gastrointestinal symptoms.Klebsiella ozaenaewas isolated from blood cultures. She had a prompt response to antibiotics and recovered completely in a short period. Subsequent evaluation of her nasal cavity and sinuses did not show any abnormalities.Klebsiella ozaenaeis primarily a colonizer of the oral and nasopharyngeal mucosa, which does not usually cause severe infections. Only 12 cases ofKlebsiella ozaenaebacteremia have been reported, none of them in the context of solid organ transplant recipient.

scholarly journals Microsporidia Infection in a Mexican Kidney Transplant Recipient

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Oscar Xavier Hernández-Rodríguez ◽  
Octavio Alvarez-Torres ◽  
Norma Ofelia Uribe-Uribe
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Asymptomatic Patients ◽  
Immunodeficiency Virus ◽  
Hygienic Conditions

Microorganisms of the microsporidia group are obligated intracellular protozoa that belong to the phylum Microspora; currently they are considered to be related or belong to the fungi reign. It is considered an opportunistic infection in humans, and 14 species belonging to 8 different genera have been described. Immunocompromized patients such as those infected with human immunodeficiency virus (HIV), also HIV serum-negative asymptomatic patients, with poor hygienic conditions, and recipients of bone marrow or solid organ transplantation are susceptible to develop deinfection. Sixtytransplantedpatients with renal microsporidia infection have been reported worldwide. The aim of this paper is to inform about the 2nd case of kidney transplant and microsporidia infection documented in Mexico.

scholarly journals Severe Acute Respiratory Syndrome Corona Virus-2 Infection in a Pediatric Kidney Transplant Recipient: A Case Report from India

2021 ◽  
pp. 367-373
Author(s):  
Ravi Raju Tatapudi ◽  
Venkateswara Rao Kopparti ◽  
Anusha Poosapati ◽  
Srinivas Metta ◽  
Vedita Palli ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Solid Organ Transplantation ◽  
Clinical Manifestations ◽  
Severe Illness ◽  
Solid Organ ◽  
Corona Virus

COVID-19 pandemic affected millions of people across India. COVID-19 cases are fewer in children with less severity and better outcomes than in adults. However, a small proportion develop severe illness and succumb to the disease. Clinical manifestations and optimal management of COVID-19 in immunocompromised children are not clearly known. Remdesivir was shown to be efficient in reducing the recovery time in COVID-19 patients requiring supplemental oxygen. Remdesivir is approved for use in children with severe COVID-19, but there are no guidelines in patients with risk factors like recent solid organ transplantation. We report a case of a 10-year-old kidney transplant recipient (KTR) infected with severe acute respiratory syndrome corona virus-2, 2.5 months after the transplantation. Unlike most children, he presented with high fever, cough, and vomiting. His inflammatory markers were elevated. In this case report, we discussed management and clinical outcomes of this patient. In view of recent kidney transplantation and the severity of infection with emergent oxygen requirement, we gave him remdesivir. We continued prednisolone and tacrolimus and stopped mycophenolate. He recovered completely in 7 days. We feel that severely immunosuppressed KTR children with COVID-19 will benefit with remdesivir administration. Monitoring tacrolimus trough levels is essential for maintaining adequate immunosuppression.

scholarly journals FusariumInfection in a Kidney Transplant Recipient Successfully Treated with Voriconazole

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Ahmed M. Alkhunaizi ◽  
Ali M. Bazzi ◽  
Ali A. Rabaan ◽  
Elwaleed A. Ahmed
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
High Mortality ◽  
Kidney Transplant Recipient ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Fusariuminfections in solid-organ transplant recipients are rare and carry high mortality. We report a case of a kidney transplant recipient who developed infection withFusariumspecies. The patient received treatment with oral voriconazole for five months with good response.

scholarly journals A Pediatric Case of Sirolimus-Associated Pneumonitis After Kidney Transplantation

2020 ◽  
Vol 25 (5) ◽  
pp. 459-464 ◽  
Author(s):  
Jelte Kelchtermans ◽  
Jessica Chang ◽  
Wendy Glaberson ◽  
Marissa DeFreitas ◽  
Monica Alba-Sandoval ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Pulmonary Toxicity ◽  
Pediatric Population ◽  
Kidney Transplant Recipient ◽  
Ventilatory Support ◽  
Solid Organ Transplantation ◽  
Adult Patients ◽  
High Dose ◽  
Solid Organ ◽  
Drug Concentrations

Sirolimus is an immunosuppressive medication often used in solid organ transplantation. It has been associated with severe side effects, including pulmonary toxicity. In adult patients, a single center study found that 14% of those treated with sirolimus developed pulmonary pneumonitis; however, the incidence in the pediatric population is not known. Most reports in adult patients indicate that elevated drug concentrations and a prolonged duration of use are associated with pulmonary toxicity. We report a case of a 17-year-old male kidney transplant recipient who developed rapid-onset respiratory failure, necessitating mechanical ventilation and acute renal replacement therapy for ultrafiltration secondary to sirolimus-induced pneumonitis. He had been treated for acute rejection with corticosteroids 17 days prior to the development of pneumonitis. His symptoms developed within 1 week of initiation of sirolimus and with a serum concentration of 1.1 ng/mL. Sirolimus was discontinued, and, following aggressive diuresis and ventilatory support, his respiratory status returned to baseline. Sirolimus-induced pneumonitis is an important diagnosis to be considered in any transplant recipient receiving sirolimus with new onset fever, cough, or dyspnea without an identifiable source, especially if there is a preceding history of treatment with high-dose corticosteroids.

scholarly journals Trichodysplasia spinulosa in a renal transplant patient: A case report of successful treatment

2020 ◽  
Vol 8 ◽  
pp. 2050313X2095303
Author(s):  
Camille Pennou ◽  
Eileen Javidi ◽  
Julie Lecours ◽  
Annie Bélisle ◽  
Sandra Davar
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Immunosuppressive Therapy ◽  
Kidney Transplant ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Kidney Transplant Recipient ◽  
Solid Organ ◽  
Immunocompromised Patients

Trichodysplasia spinulosa is a rare cutaneous disease caused by the trichodysplasia spinulosa–associated polyomavirus. It occurs more frequently in immunocompromised patients, particularly in solid organ transplants. A few successful treatments have been described in the literature. In our report, we present a biopsy-proven trichodysplasia spinulosa case in a kidney transplant recipient who rapidly responded to a reduction of his immunosuppressive therapy.

scholarly journals Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Romain Vial ◽  
Christine Zandotti ◽  
Sophie Alain ◽  
Alexandre Decourt ◽  
Noémie Jourde-Chiche ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Liver Toxicity ◽  
Kidney Transplant Recipient ◽  
Antiviral Drug ◽  
Viral Gene ◽  
Solid Organ ◽  
Ganciclovir Treatment ◽  
Cmv Disease ◽  
Ul54 Gene

Background. Cytomegalovirus (CMV) antiviral drug resistance constitutes an increasing challenge in transplantation. Foscarnet is usually proposed when resistance for ganciclovir is suspected, but its use is limited by its nephrotoxicity. Case Presentation. We report a case of multiresistant CMV disease in a kidney transplant recipient. Foscarnet was prescribed after ganciclovir treatment failure in a patient with two mutations in the UL97 viral gene. Foscarnet induced biopsy-proven kidney crystal precipitation that resulted in severe acute transplant failure and nephrotic syndrome. Despite a large decrease in immunosuppression, CMV disease was not controlled and a salvage therapy with Brincidofovir (BCV), which is an oral lipid conjugate of cidofovir with limited nephrotoxicity, was attempted. Clinical and virological remission was observed after a 21-day course of BCV, despite mild and reversible liver toxicity. However, a new relapse could not be effectively cured by BCV due to a new mutation in the UL54 gene, which is known to confer resistance to cidofovir. A new course of foscarnet finally resulted in prolonged CMV remission. Herein, we present a review of foscarnet nephropathy cases in solid-organ transplanted patients. Conclusions. This unique case highlights the potential benefit of BCV use during resistant CMV infection, although mutations in the UL54 gene may limit its therapeutic efficacy. These findings need to be confirmed in clinical trials.

scholarly journals Chikungunya in a kidney transplant recipient: a case report

2019 ◽  
Vol 41 (4) ◽  
pp. 575-579 ◽  
Author(s):  
Renato Demarchi Foresto ◽  
Daniel Wagner de Castro Lima Santos ◽  
Maria Amélia Aguiar Hazin ◽  
Alejandro Túlio Zapata Leyton ◽  
Nayara Cordeiro Tenório ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Organ Transplant ◽  
Disease Outbreaks ◽  
Solid Organ ◽  
Northeast Brazil ◽  
Endemic Region ◽  
Chikungunya Fever ◽  
Endemic Areas

ABSTRACT In 2004, a global spread of Chikungunya fever affected most tropical and subtropical regions of the world. In 2016, an outbreak occurred in Northeast Brazil with hundreds of cases documented. Solid organ transplant recipients have a modified immune response to infection and the clinical course is usually different from immunocompetent patients. The diagnosis can be challenging in this population. Most reports describe patients residing in endemic areas, although we must emphasize the importance of differential diagnosis in kidney transplanted travelers who visit endemic regions, such as Northeast Brazil. Here, we reported a case of a kidney transplant recipient that acquired Chikungunya fever after a trip to an endemic region at Northeast Brazil during the outbreak in 2016, with a good clinical evolution. We also present warning recommendations for travelers to endemic areas as additional measures to prevent disease outbreaks.

Urban Spread of Flaviviruses: A New Challenge in Solid-organ Transplant Recipients

2019 ◽  
Vol 70 (1) ◽  
pp. 149-151
Author(s):  
Paolo Antonio Grossi
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Yellow Fever ◽  
Kidney Transplant Recipient ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
The World ◽  
Solid Organ Transplant Recipients

Abstract Yellow fever has never previously been reported in transplant recipients. The first reported case of yellow fever in a kidney transplant recipient in Brazil and the re-emergence of arboviruses in many areas of the world dictate the need of studies aimed to answer multiple unanswered questions.

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