Risk of hepatitis‐E virus infections among blood donors in a regional blood transfusion centre in western India

Aim: Hepatitis E virus (HEV) transmission through blood transfusion is a major public health issue worldwide. We aimed to determine the seroprevalence of HEV in blood donors in the Qassim region of Saudi Arabia. Materials & methods: Serum samples (n = 1078) were collected from volunteer blood donors and tested for the presence of anti-HEV IgG and IgM by indirect ELISA. Results: The seroprevalence of anti-HEV IgG among the blood donors was 5.7% overall. Anti-HEV IgG and IgM seropositivity were significantly higher in non-Saudi donors than in Saudi donors (22.1 vs 3 and 7.8 vs 0.2% for anti-HEV IgG and IgM, respectively). Conclusion: The seroprevalence of HEV among blood donors in the Qassim region was lower than previous estimates for other regions of the country and neighboring countries.

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The association of elevated alanine aminotransferase levels with hepatitis E virus infections among blood donors in China

Transfusion ◽

10.1111/trf.13991 ◽

2017 ◽

Vol 57 (2) ◽

pp. 273-279 ◽

Cited By ~ 6

Author(s):

Meiyu Wang ◽

Miao He ◽

Binting Wu ◽

Ling Ke ◽

Tingting Han ◽

...

Keyword(s):

Alanine Aminotransferase ◽

Hepatitis E Virus ◽

Blood Donors ◽

Hepatitis E ◽

Virus Infections

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Seroprevalence of the hepatitis E virus among blood donors in the Qassim Region, Saudi Arabia

10.21203/rs.3.rs-18073/v1 ◽

2020 ◽

Author(s):

Bader Alhatlani ◽

Waleed Aljabr ◽

Mohammed Almarzouqi ◽

Sami Alhatlani ◽

Rayan Alzunaydi ◽

...

Keyword(s):

Public Health ◽

Saudi Arabia ◽

Blood Transfusion ◽

Hepatitis E Virus ◽

Blood Donors ◽

Geographical Area ◽

Hepatitis E ◽

Public Health Issue ◽

Serum Samples ◽

Major Public Health Issue

Abstract Objectives The aim of this study was to evaluate the seroprevalence of hepatitis E virus (HEV), a major public health issue worldwide with the potential for transmission via blood transfusion, in blood donors in the Qassim Region, Saudi Arabia. Serum samples (n = 1,078) were collected from volunteer blood donors from January to April 2019 and tested for the presence of anti-HEV IgG and IgM by indirect enzyme-linked immunosorbent assays. Results Overall, the seroprevalence of anti-HEV IgG and IgM among blood donors was 5.7% and 1.3%, respectively. Additionally, the seropositive rates of anti-HEV IgG and IgM were significantly higher in non-Saudi donors (22.1% and 7.8%) than in Saudi donors (3% and 0.2%). The seroprevalence of anti-HEV IgG increased with age; however, there was no correlation between gender and anti-HEV IgG and/or IgM. The seroprevalence of HEV among blood donors in the Qassim Region was lower than previous estimates for other regions of the country. Further studies covering a wider geographical area are needed to validate and expand the findings and to determine the importance of HEV screening in the region.

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Case–Control Study of Risk Factors for Acquired Hepatitis E Virus Infections in Blood Donors, United Kingdom, 2018–2019

Emerging Infectious Diseases ◽

10.3201/eid2706.203964 ◽

2021 ◽

Vol 27 (6) ◽

pp. 1654-1661

Author(s):

Iona Smith ◽

Bengü Said ◽

Aisling Vaughan ◽

Becky Haywood ◽

Samreen Ijaz ◽

...

Keyword(s):

Risk Factors ◽

United Kingdom ◽

Hepatitis E Virus ◽

Blood Donors ◽

Case Control Study ◽

Hepatitis E ◽

Case Control ◽

Virus Infections ◽

Control Study

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Low Hepatitis E Virus Prevalence Among Blood Donor in Dali in China

10.21203/rs.3.rs-118265/v1 ◽

2020 ◽

Author(s):

Ping Fu ◽

Baochai Lin ◽

Bingting Wu ◽

Ling Ke ◽

Tianfu Yang ◽

...

Keyword(s):

Blood Transfusion ◽

Ethnic Minority ◽

Odds Ratio ◽

Hepatitis E Virus ◽

Blood Donors ◽

Hepatitis E ◽

Enzyme Linked Immunosorbent Assay ◽

Serum Samples ◽

Iga Antibodies ◽

Positive Rate

Abstract BACKGROUND: Hepatitis E virus (HEV) is a nonenveloped RNA virus causing Hepatitis E worldwide. An increasing transfusion transmission cases of HEV infections from asymptomatic blood donors which causing serious illnesses in immunosuppressed recipients have been reported in the past few years. China is one of the highly prevalent regions of HEV, it is important to evaluate the risk of HEV transmission from blood transfusion. METHODS: A total of 1864 serum samples from blood donors and demographic characteristics were randomly collected from Feb to Mar 2018 in Dali city. Anti-HEV IgG, IgM and IgA antibodies and HEV antigen were examined by enzyme-linked immunosorbent assay (ELISA). HEV RNA was detected by real-time PCR. Multivariable logistic regression modelling was used to examine risk factors associated with HEV prevalence.RESULTS: Overall, the positive rate of anti-HEV IgG, IgM, and IgA antibodies was 13.36% (249/1864), 1.13%(21/1864), and 1.82%(34/1864), respectively. However, none of the 1864 serum samples was detected as HEV antigen-positive nor HEV RNA positive. The positive rate of anti-HEV IgG antibody is high as 28.57% (2/7) in the donors with isolated elevated alanine aminotransferase (ALT). Females (16.69%) had a significantly higher HEV seroprevalence than males (13.04%) (odds ratio [OR]: 1.34 [95% CI, 1.02-1.75]). Other ethnic minority (24.32%) and Bai (18.85%) donors had a significantly higher HEV seroprevalence when compared to Han (12.21%) blood donors (odds ratio [OR], 2.25 [95% CI, 1.04-4.88] for other ethnic minority, 1.65 [95% CI, 1.24-2.19] for Bai). Conclusions: Dali, Yunnan province, China is an endemic region for HEV and have a relatively low risk of HEV transmission via blood transfusion. Whether to formulate the strategy for HEV screening in blood center needed further researched.

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Low Hepatitis E virus prevalence among blood donor in Dali in China

10.21203/rs.3.rs-118265/v2 ◽

2021 ◽

Author(s):

Ping Fu ◽

Baochai Lin ◽

Bingting Wu ◽

Ling Ke ◽

Tianfu Yang ◽

...

Keyword(s):

Risk Factors ◽

Blood Transfusion ◽

Ethnic Minority ◽

Odds Ratio ◽

Hepatitis E Virus ◽

Blood Donors ◽

Hepatitis E ◽

Serum Samples ◽

Iga Antibodies ◽

Positive Rate

Abstract BACKGROUND: Hepatitis E virus (HEV) is a nonenveloped RNA virus causing Hepatitis E worldwide. An increasing transfusion transmission cases of HEV infections from asymptomatic blood donors which causing serious illnesses in immunosuppressed recipients have been reported in the past few years. China is one of the highly prevalent regions of HEV, it is important to evaluate the risk of HEV transmission from blood transfusion. METHODS: A total of 1864 serum samples from blood donors and demographic characteristics were randomly collected from Feb to Mar 2018 in Dali city. Anti-HEV IgG, IgM and IgA antibodies and HEV antigen were examined by enzyme-linked immunosorbent assay (ELISA). HEV RNA was detected by real-time PCR. Multivariable logistic regression modelling was used to examine risk factors associated with HEV prevalence.RESULTS: Overall, the positive rate of anti-HEV IgG, IgM, and IgA antibodies was 13.36% (249/1864), 1.13%(21/1864), and 1.82%(34/1864), respectively. However, none of the 1864 serum samples was detected as HEV antigen-positive nor HEV RNA positive. The positive rate of anti-HEV IgG antibody is high as 28.57% (2/7) in the donors with isolated elevated alanine aminotransferase (ALT). Females (16.69%) had a significantly higher HEV seroprevalence than males (13.04%) (odds ratio [OR]: 1.34 [95% CI, 1.02-1.75]). Other ethnic minority (24.32%) and Bai (18.85%) donors had a significantly higher HEV seroprevalence when compared to Han (12.21%) blood donors (odds ratio [OR], 2.25 [95% CI, 1.04-4.88] for other ethnic minority, 1.65 [95% CI, 1.24-2.19] for Bai). Conclusions: Dali, Yunnan province, China is an endemic region f of hepatitis E virus, and women, Bai and other ethnic minorities may be potential risk factors for hepatitis E virus infection.. The risk of transmission of hepatitis E virus through blood transfusion is relatively low, and the specific risk value needs to be further tested by expanding the sample size. Whether to formulate the strategy for HEV screening in blood center needed further researched.

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A Nationwide Survey of the Seroprevalence of Hepatitis E Virus Infections Among Blood Donors in Thailand

Viral Immunology ◽

10.1089/vim.2018.0146 ◽

2019 ◽

Vol 32 (7) ◽

pp. 302-307 ◽

Cited By ~ 3

Author(s):

Sujittra Jupattanasin ◽

Siwaporn Chainuvati ◽

Watcharasak Chotiyaputta ◽

Tipsuda Chanmanee ◽

Orawan Supapueng ◽

...

Keyword(s):

Hepatitis E Virus ◽

Blood Donors ◽

Nationwide Survey ◽

Hepatitis E ◽

Virus Infections

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Seroprevalence of the hepatitis E virus among blood donors in the Qassim Region, Saudi Arabia

10.21203/rs.3.rs-18073/v2 ◽

2020 ◽

Author(s):

Bader Alhatlani ◽

Waleed Aljabr ◽

Mohammed Almarzouqi ◽

Sami Alhatlani ◽

Rayan Alzunaydi ◽

...

Keyword(s):

Public Health ◽

Saudi Arabia ◽

Blood Transfusion ◽

Hepatitis E Virus ◽

Blood Donors ◽

Geographical Area ◽

Hepatitis E ◽

Public Health Issue ◽

Serum Samples ◽

Major Public Health Issue

Abstract ObjectivesTo evaluate the seroprevalence of hepatitis E virus (HEV), a major public health issue worldwide with the potential for transmission via blood transfusion, in blood donors in the Qassim Region, Saudi Arabia. Serum samples (n = 1,078) were collected from volunteer blood donors from January to April 2019 and tested for the presence of anti-HEV IgG and IgM by indirect enzyme-linked immunosorbent assays.ResultsOverall, the seroprevalence of anti-HEV IgG among blood donors was 5.7%. Additionally, the seropositive rates of anti-HEV IgG and IgM were significantly higher in non-Saudi donors (22.1% and 35.3%) than in Saudi donors (3% and 7.4%). The seroprevalence of anti-HEV IgG increased with age; however, there was no correlation between gender and anti-HEV IgG and/or IgM. The seroprevalence of HEV among blood donors in the Qassim Region was lower than previous estimates for other regions of the country. Further studies covering a wider geographical area are needed to validate and expand the findings and to determine the importance of HEV screening in the region.

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