Clinical characteristics of and antibody response to spotted fever group rickettsial infections in South India: Case series and serological cohort study

2021 ◽  
Author(s):  
Wolf‐Peter Schmidt ◽  
Carol S. Devamani ◽  
Divyaa Elangovan ◽  
Neal Alexander ◽  
Winsley Rose ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antibody Response ◽  
Clinical Characteristics ◽  
South India ◽  
Spotted Fever ◽  
Case Series ◽  
Spotted Fever Group ◽  
Rickettsial Infections

scholarly journals Molecular and serological evidence of flea-associated typhus group and spotted fever group rickettsial infections in Madagascar

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Rado J. L. Rakotonanahary ◽  
Alan Harrison ◽  
Alice N. Maina ◽  
Ju Jiang ◽  
Allen L. Richards ◽  
...  
Keyword(s):  
Spotted Fever ◽  
Spotted Fever Group ◽  
Serological Evidence ◽  
Rickettsial Infections

Rickettsial Infections around the World, Part 1: Pathophysiology and the Spotted Fever Group

2005 ◽  
Vol 9 (2) ◽  
pp. 54-62
Author(s):  
Jashin J. Wu ◽  
David B. Huang ◽  
Katie R. Pang ◽  
Stephen K. Tyring
Keyword(s):  
Spotted Fever ◽  
Clinical Manifestations ◽  
Review Article ◽  
Learning Activity ◽  
Clinical Aspects ◽  
Spotted Fever Group ◽  
Infectious Agents ◽  
Important Group ◽  
Rickettsial Infections ◽  
Rickettsial Diseases

Background: The rickettsial diseases are an important group of infectious agents that have dermatological manifestations. These diseases are important to consider in endemic areas, but in certain suspicious cases, possible acts of bioterrorism should warrant prompt notification of the appropriate authorities. Objective: In this two part review article, we review these diverse diseases by examining established and up-to-date information about the pathophysiology, epidemiology, clinical manifestations, and treatment of the ricksettsiae. Methods: Using PubMed to search for relevant articles, we browsed over 500 articles to compose a clinically based review article. Results: Part one focuses on pathophysiology of the rickettsial diseases and the clinical aspects of the spotted fever group. Conclusions: At the completion of part one of this learning activity, participants should be able to discuss all of the clinical manifestations and treatments of the sported fever group. Participants should also be familiar with the pathophysiology of the rickettsial diseases.

scholarly journals Diagnosis of spotted fever group Rickettsia infections: the Asian perspective

2019 ◽  
Vol 147 ◽  
Author(s):  
Matthew T. Robinson ◽  
Jaruwan Satjanadumrong ◽  
Tom Hughes ◽  
John Stenos ◽  
Stuart D. Blacksell
Keyword(s):  
Positive Result ◽  
Diagnostic Tests ◽  
Quantitative Polymerase Chain Reaction ◽  
Spotted Fever ◽  
Emerging Infectious Diseases ◽  
Immunofluorescence Assay ◽  
Diagnostic Methods ◽  
Spotted Fever Group ◽  
Sample Collection ◽  
Rickettsial Infections

Abstract Spotted fever group rickettsiae (SFG) are a neglected group of bacteria, belonging to the genus Rickettsia, that represent a large number of new and emerging infectious diseases with a worldwide distribution. The diseases are zoonotic and are transmitted by arthropod vectors, mainly ticks, fleas and mites, to hosts such as wild animals. Domesticated animals and humans are accidental hosts. In Asia, local people in endemic areas as well as travellers to these regions are at high risk of infection. In this review we compare SFG molecular and serological diagnostic methods and discuss their limitations. While there is a large range of molecular diagnostics and serological assays, both approaches have limitations and a positive result is dependent on the timing of sample collection. There is an increasing need for less expensive and easy-to-use diagnostic tests. However, despite many tests being available, their lack of suitability for use in resource-limited regions is of concern, as many require technical expertise, expensive equipment and reagents. In addition, many existing diagnostic tests still require rigorous validation in the regions and populations where these tests may be used, in particular to establish coherent and worthwhile cut-offs. It is likely that the best strategy is to use a real-time quantitative polymerase chain reaction (qPCR) and immunofluorescence assay in tandem. If the specimen is collected early enough in the infection there will be no antibodies but there will be a greater chance of a PCR positive result. Conversely, when there are detectable antibodies it is less likely that there will be a positive PCR result. It is therefore extremely important that a complete medical history is provided especially the number of days of fever prior to sample collection. More effort is required to develop and validate SFG diagnostics and those of other rickettsial infections.

Clinical Features of Rickettsial Infection in Children in Tropical Australia—A Report of 15 Cases

2020 ◽  
Vol 66 (6) ◽  
pp. 655-660 ◽  
Author(s):  
Alexandra G A Stewart ◽  
Simon Smith ◽  
Enzo Binotto ◽  
Josh Hanson
Keyword(s):  
Scrub Typhus ◽  
Spotted Fever ◽  
Case Fatality ◽  
Spotted Fever Group ◽  
Tertiary Referral Hospital ◽  
Admission Rates ◽  
Rickettsial Infections ◽  
Retrospective Audit ◽  
Tropical Australia ◽  
The Tropics

Abstract Rickettsial infections are an under-recognized cause of acute, undifferentiated fever in the tropics. In Asia, intensive care unit (ICU) admission rates as high as 21% and case-fatality rates of up to 5% have been reported. This 20-year retrospective audit of children and adults with serologically confirmed scrub typhus or spotted fever group (SFG) infection was performed at a tertiary-referral hospital in tropical Australia. There were 15 paediatric cases during the study period (11 scrub typhus, 3 SFG and 1 undifferentiated). Hypotension [5/15 (33%)], tachycardia [6/15 (40%)] and tachypnoea [6/15 (40%)] were common at presentation. Children were more likely to be hypotensive at admission than adults [5/15 (33%) vs. 5/118 (4%), p = 0.002]. However, no child died or was admitted to ICU, compared with 18/120 (15%) adults who required ICU support during the study period, one of whom died. Paediatric rickettsial infections have a relatively benign clinical course in tropical Australia with serious complications appearing far less frequently than have been reported in the Asian literature.

Spotted Fever Group Rickettsial Infections in Australia

1991 ◽  
Vol 13 (5) ◽  
pp. 876-886 ◽  
Author(s):  
D. J. Sexton ◽  
B. Dwyer ◽  
R. Kemp ◽  
S. Graves
Keyword(s):  
Spotted Fever ◽  
Spotted Fever Group ◽  
Rickettsial Infections

Rickettsial Infections Around the World, Part 1: Pathophysiology and the Spotted Fever Group

2005 ◽  
Vol 9 (2) ◽  
pp. 54-62 ◽  
Author(s):  
Jashin J. Wu ◽  
David B. Huang ◽  
Katie R. Pang ◽  
Stephen K. Tyring
Keyword(s):  
Spotted Fever ◽  
Spotted Fever Group ◽  
Rickettsial Infections ◽  
The World

Seroprevalence of Rickettsial Infections in Northeast India: A Population-Based Cross-Sectional Survey

2021 ◽  
pp. 101053952110158
Author(s):  
Siraj A. Khan ◽  
Manoj V. Murhekar ◽  
Trishna Bora ◽  
Santhosh Kumar ◽  
Jahnabi Saikia ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Spotted Fever ◽  
Age Groups ◽  
Population Based ◽  
Northeast India ◽  
Spotted Fever Group ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Spotted Fever Group Rickettsiae ◽  
Rickettsial Infections

A cross-sectional survey was undertaken to estimate seroprevalence of immunoglobulin G antibodies against scrub typhus, spotted fever group rickettsiae, and typhus group rickettsiae in randomly selected 48 clusters in 12 districts of 3 Northeast states of India: Assam, Meghalaya, and Tripura. Individuals in 3 age groups (5-8, 9-17, and 18-45 years) were selected from each cluster. Sera (N = 2360) tested were collected as part of a national survey on dengue seroprevalence conducted between September 2017 and February 2018. Overall, seroprevalence of 2.5% was detected against rickettsioses, with highest positivity against spotted fever group rickettsiae, followed by scrub typhus and typhus group rickettsiae. Seroprevalence was highest in Tripura (3.7%), followed by Assam (2.6%) and Meghalaya (1.04%). Adults of 18 to 45 years of age were found to be most affected (3.8%). The study findings indicate the need for increasing testing facilities for active case detection at hospital levels. Efforts on implementing effective preventing strategies are suggested to be targeted in disease-specific endemic foci.

scholarly journals First report of the molecular detection of human pathogen Rickettsia raoultii in ticks from the Republic of Korea

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Misbah Tariq ◽  
Jun-Won Seo ◽  
Da Young Kim ◽  
Merlin Jayalal Lawrence Panchali ◽  
Na Ra Yun ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Citrate Synthase ◽  
Phylogenetic Analyses ◽  
Spotted Fever ◽  
Republic Of Korea ◽  
Spotted Fever Group ◽  
Haemaphysalis Longicornis ◽  
Rickettsia Raoultii ◽  
Rickettsial Infections ◽  
The Republic

Abstract Background Rickettsial diseases associated with the spotted fever group constitute a growing number of newly identified Rickettsia pathogens and their tick vectors in various parts of the world. At least 15 distinct tick species belonging to six genera have shown the presence of Rickettsia raoultii. Herein, we report the detection of R. raoultii in ticks from the Republic of Korea (ROK). Methods Thirty-five ticks were collected from 29 patients with tick bites in Gwangju Metropolitan City, Jeollanam Province, ROK. The ticks were identified using molecular, morphological, and taxonomic characteristics. All samples were screened for presence of Rickettsia species using nested polymerase chain reactions of their outer membrane protein (ompA) and citrate synthase (gltA) genes. The amplified products were sequenced for subsequent phylogenetic analyses. Results Sequencing data showed the DNA sequences of R. raoultii in three Haemaphysalis longicornis ticks. All three tick samples were 99.4–100% similar to previously reported partial sequences of ompA of R. raoultii strains CP019435 and MF002523, which formed a single clade with the reference strains. Conclusions We provide the first description and molecular identification of R. raoultii detected in H. longicornis ticks in the ROK. This observation extends the geographical distribution of R. raoultii. Screening of human samples for this pathogen will provide information about the prevalence of rickettsial infections in this region.

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