scholarly journals Synthesis, characterization and fungicidal activity of some diorganotin(IV) with 2-thioacetic-5-phenyl-1,3,4-oxadiazole

2014 ◽  
Vol 5 (2) ◽  
Author(s):  
Emad Yousif ◽  
Hadeel Adil ◽  
Ahmed Majeed ◽  
Yang Farina
Keyword(s):  
Fungicidal Activity ◽  
Octahedral Geometry ◽  
In Vitro Tests ◽  
Cercospora Arachidicola ◽  
Electrolytic Conductance ◽  
Physico Chemical ◽  
119Sn Nmr ◽  
Nmr Techniques ◽  
Uv Visible

Complexes of the type R2SnL2, where R = phenyl, butyl and methyl and LH = 2-thioacetic-5-phenyl-1,3,4-oxadiazole, have been synthesized and characterized by physico-chemical (elemental analysis, and electrolytic conductance) and spectral (UV-Visible, IR and (1H, 13C and 119Sn NMR) techniques. Monomer structures for the complexes, bidentate and octahedral geometry was proposed for the complexes prepared. Preliminary in vitro tests for fungicidal activity show that all prepared compounds display good activity to Gibberela, Cercospora arachidicola, Physolospora piricola and Fusarium oxysporum. Moreover, the Ph2SnL2 shows a higher inhibition percentage then diorganotin carboxylate.

scholarly journals Synthesis, characterization and antimicrobial Studies of complexes of some metal ions with 5(2-hydroxy benzylidine) -2-thio ether -1, 3, 4-thiadiazole

2010 ◽  
Vol 7 (1) ◽  
pp. 585-592
Author(s):  
Baghdad Science Journal
Keyword(s):  
Iron Complex ◽  
Octahedral Geometry ◽  
Planar Geometry ◽  
In Vitro Tests ◽  
Conductivity Measurements ◽  
Antimicrobial Studies ◽  
Square Planar ◽  
Escherchia Coli ◽  
Complex Display

A new series of Fe (III) , Co (II) , Ni (II) and Cu (II) complexes of the Schiff base, 5 (2-hydroxy benzylidine) -2-thio ether -1, 3, 4-thiadiazole were prepared and characterized .The imine behaves as a bidentate. The nature of bonding and the stereochemistry of the complexes were deduced from metal analyses, infrared, electronic spectra,magnetic susceptibility and conductivity measurements, an octahedral geometry was suggested for all complexes except the copper complex has a square planar geometry .preliminary in vitro tests for antimicrobial activity show that all the prepared compounds except iron complex display good activity to gram positive Staphelococcus aures and gram negative Escherchia coli.

scholarly journals Synthesis, Characterization and in vitro Antimicrobial, Anticancer Activity of Random Copolyester using Orcinol

2021 ◽  
Vol 33 (9) ◽  
pp. 2119-2126
Author(s):  
T. Sivaramakrishnan ◽  
G. Elango
Keyword(s):  
In Vitro Cytotoxicity ◽  
Diffusion Method ◽  
Dsc Studies ◽  
Repeat Units ◽  
Nmr Techniques ◽  
Crystalline Nature ◽  
Uv Visible ◽  
Tga And Dsc

In present study, a novel random copolyester i.e. poly(3-oxy-5-methylphenyl-4-oxynaphthal-1- yl)isophthalate (PONI) was synthesized through solution polycondensation methodology involving orcinol, 1,4-naphthalene diol and isophthaloyl chloride and its solubility in common solvents along with viscosity measurements were performed. The structure of the repeat units in the polyester chain were ascertained based on the spectral characterization of UV-visible, FTIR, 1H & 13C NMR techniques. Thermal analysis of the copolyester were performed by TGA and DSC studies. The activation energy for thermal decomposition of polyester was estimated by well-known kinetic methods. The surface morphology and crystalline nature of the polymer were explored by employing SEM and WAXD methods. The antimicrobial efficacy of copolyester was assessed through well-diffusion method using a Gram-positive and a Gram-negative bacteria. The in vitro cytotoxicity of the polyester prepared was verified against HeLa cell line using MTT assay.

Synthesis and pesticidal activity of some 4-Azolylmethyl-1,3-dioxolanes, based on cyclic ketones

2021 ◽  
pp. 6417-6422
Author(s):  
V.S. Talismanov ◽  
S.V. Popkov ◽  
S.S. Zykova ◽  
О.G. Karmanova
Keyword(s):  
Fungicidal Activity ◽  
In Vitro Tests ◽  
Cyclic Ketones ◽  
Entire Concentration Range ◽  
Sodium Salts

In vitro tests of substituted 1,3-dioxolanes, based on cyclic ketones and substituted with 1H-1,2,4-triazole and 1H-imidazole showed a fungicidal activity lower than the activity of the triadimefon, and spiroxamine. Studied compounds in the entire concentration range: from 0.001 to 10 mg/L showed noticeable retardant properties. The target compounds were derived by cyclization of substituted cyclohexanones with epichlorohydrin followed by alkylation of the derived 2 chloromethyl-1,3 dioxolanes of sodium salts of imidazole or 1,2,4-triazole.

scholarly journals Synthesizing, Structuring, and Characterizing Bioactivities of .Cr(III), La(III), and Ce(III) .Complexes with Nitrogen, Oxygen .and Sulpher donor bidentate Schiff base ligands

2021 ◽  
Vol 18 (4(Suppl.)) ◽  
pp. 1545
Author(s):  
Anaam M. Rasheed ◽  
Sinan M. M. Al-Bayati ◽  
Dr.Rehab A.M. Al-Hasani ◽  
Muna Ali Shakir
Keyword(s):  
Schiff Bases ◽  
Schiff Base Ligands ◽  
Minimal Inhibitory Concentrations ◽  
Gram Positive Bacteria ◽  
Physico Chemical ◽  
Visible Spectra ◽  
Ft Ir ◽  
Uv Visible ◽  
Anti Fungal

Two Schiff bases, namely, 3-(benzylidene amino) -2-thioxo-6-methyl 2,5-dihydropyrimidine-4(3H)-one (LS])and 3-(benzylidene amino)-6-methyl pyrimidine 4(3H, 5H)-dione(LA)as chelating ligands), were used to prepare some complexes of Cr(III), La(III), and Ce(III)] ions. Standard physico-chemical procedures including metal analysis M%, element microanalysis (C.H.N.S) , magnetic susceptibility, conductometric measurements, FT-IR and UV-visible Spectra were used to identify Metal (III) complexes and  Schiff bases (LS) and (LA). According to findings, a [Cr(III) complex] showed six coordinated octahedral geometry, while [La(III), and Ce(III) complexes]were structured with coordination number seven.  Schiff's bases and mineral complexes were examined in vitro to investigate potential inhibition against Gram-positive bacteria such as Pseudonomous aerugionosa and Gram-negative bacteria such as Staphylococcus aureus. The low concentration for inhibition has been also determined by studying the minimal inhibitory concentrations MIC .Antibiotics (Ampicillin, Amoxicillin) have been chosen to contrast their activity. Furthermore, Anti-fungal activity against two types of fungi ʺAspergillus flavusʺ and ʺPenicillum Spp.ʺ was studied for these compounds. The results of the antibacterial activity were better compared to the standard drugs.

scholarly journals Antifungal and Spectral Studies of Cr(III) and Mn(II) Complexes Derived from 3,3′-Thiodipropionic Acid Derivative

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Sulekh Chandra ◽  
Amit Kumar Sharma
Keyword(s):  
Magnetic Susceptibility ◽  
Acid Derivative ◽  
Elemental Analysis ◽  
Fungicidal Activity ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Bonding Parameters ◽  
Metal Ligand

The Cr(III) and Mn(II) complexes with a ligand derived from 3,3′-thiodipropionic acid have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, IR, UV, and EPR spectral studies. The complexes are found to have [Cr(L)X]X2 and [Mn(L)X]X, compositions, where L = quinquedentate ligand and X=NO3−, Cl− and OAc−. The complexes possess the six coordinated octahedral geometry with monomeric compositions. The evaluated bonding parameters, Aiso and β, account for the covalent type metal-ligand bonding. The fungicidal activity of the compounds was evaluated in vitro by employing Food Poison Technique.

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

Comparison of High Purity Factor IX Concentrates and a Prothrombin Complex Concentrate in a Canine Model of Thrombogenicity

1991 ◽  
Vol 66 (05) ◽  
pp. 609-613 ◽  
Author(s):  
I R MacGregor ◽  
J M Ferguson ◽  
L F McLaughlin ◽  
T Burnouf ◽  
C V Prowse
Keyword(s):  
High Purity ◽  
Time Course ◽  
Prothrombin Complex Concentrate ◽  
Degradation Products ◽  
Canine Model ◽  
Factor Ix ◽  
In Vitro Tests ◽  
Albumin Infusion

SummaryA non-stasis canine model of thrombogenicity has been used to evaluate batches of high purity factor IX concentrates from 4 manufacturers and a conventional prothrombin complex concentrate (PCC). Platelets, activated partial thromboplastin time (APTT), fibrinogen, fibrin(ogen) degradation products and fibrinopeptide A (FPA) were monitored before and after infusion of concentrate. Changes in FPA were found to be the most sensitive and reproducible indicator of thrombogenicity after infusion of batches of the PCC at doses of between 60 and 180 IU/kg, with a dose related delayed increase in FPA occurring. Total FPA generated after 100-120 IU/kg of 3 batches of PCC over the 3 h time course was 9-12 times that generated after albumin infusion. In contrast the amounts of FPA generated after 200 IU/kg of the 4 high purity factor IX products were in all cases similar to albumin infusion. It was noted that some batches of high purity concentrates had short NAPTTs indicating that current in vitro tests for potential thrombogenicity may be misleading in predicting the effects of these concentrates in vivo.

A Comparison of the in Vitro and in Vivo Thrombogenic Activity of Factor IX Concentrates Using Stasis (Wessler) and Non-Stasis Rabbit Models

1980 ◽  
Vol 44 (02) ◽  
pp. 081-086 ◽  
Author(s):  
C V Prowse ◽  
A E Williams
Keyword(s):  
Platelet Rich Plasma ◽  
Thrombus Formation ◽  
Factor Ix ◽  
Coagulation System ◽  
In Vitro Tests ◽  
Clinical Use ◽  
Low Activity

SummaryThe thrombogenic effects of selected factor IX concentrates were evaluated in two rabbit models; the Wessler stasis model and a novel non-stasis model. Concentrates active in either the NAPTT or TGt50 in vitro tests of potential thrombogenicity, or both, caused thrombus formation in the Wessler technique and activation of the coagulation system in the non-stasis model. A concentrate with low activity in both in vitro tests did not have thrombogenic effects in vivo, at the chosen dose. Results in the non-stasis model suggested that the thrombogenic effects of factor IX concentrates may occur by at least two mechanisms. A concentrate prepared from platelet-rich plasma and a pyrogenic concentrate were also tested and found to have no thrombogenic effect in vivo.These studies justify the use of the NAPTT and TGt50 in vitro tests for the screening of factor IX concentrates prior to clinical use.

In Vitro Thrombogenicity Tests of Factor IX Concentrates

1979 ◽  
Vol 42 (05) ◽  
pp. 1355-1367 ◽  
Author(s):  
C V Prowse ◽  
A Chirnside ◽  
R A Elton
Keyword(s):  
Factor Viii ◽  
Partial Thromboplastin Time ◽  
Generation Time ◽  
Activated Partial Thromboplastin Time ◽  
Factor Ix ◽  
In Vitro Tests ◽  
Factor Viii Inhibitor ◽  
Factor Ixa ◽  
Viii Inhibitor

SummaryVarious factor IX concentrates have been examined in a number of in vitro tests of thrombogenicity. The results suggest that some tests are superfluous as in concentrates with activity in any of these tests activation is revealed by a combination of the non-activated partial thromboplastin time, the thrombin (or Xa) generation time and factor VIII inhibitor bypassing activity tests. Assay of individual coagulant enzymes revealed that most concentrates contained more factor IXa than Xa. However only a small number of concentrates, chiefly those that had been purposefully activated, contained appreciable amounts of either enzyme.

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