scholarly journals Aerobic exercise training and vascular function with ageing in healthy men and women

2019 ◽  
Vol 597 (19) ◽  
pp. 4901-4914 ◽  
Author(s):  
Douglas R. Seals ◽  
Erzsebet E. Nagy ◽  
Kerrie L. Moreau
Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Guevar Alkhateeb ◽  
Lars Donath

Abstract Background Sports and exercise training can attenuate age-related declines in physical function. As people age, they suffer a progressive deterioration of overall muscle structure and function, such as muscle diameter, strength, mass, and power. Therefore, supporting older adults—aged 50 years and above—to continue being physically active is a very important factor. Several forms of exercise (strength, agility, endurance, balance, and flexibility) are recommended. In this regard, football has been repeatedly shown to be an integrative approach to promote measures of strength, endurance, and agility. However, there has been no previous randomized controlled trial that comparatively investigates the effects of football training versus traditional aerobic exercise training on muscle architecture and patella tendon properties in healthy community dwellers. The study protocol is designed to examine whether football differentially affects muscle thickness, muscle length, fascicle length, pennation angle, patella tendon length, and thickness compared to a workload matched traditional aerobic exercise training regimen. Methods The study sample consists of 60 untrained but healthy men (50–60 years old), who will be randomly assigned (strata: age, activate) to two groups: football group (n = 30) and aerobic group (n = 30). The intervention will take place within 12 consecutive weeks, two times a week for 60 min each session. The football group will perform recreational football training as a large-sided game, whereas the aerobic group undergoes a running exercise. Both groups have the same external workload ranging between moderate and high exercise intensity. The outcome measure will be collected before and after the intervention period. Discussion Findings of this study will provide insight into the effects of 24 sessions of both football and aerobic training program on the selected groups of men adults, including detecting their effects on the thigh muscle architecture. Trial registration DRKS—German Clinical Trials Register, DRKS00020536. Registered on 30 January 2020.


2003 ◽  
Vol 284 (4) ◽  
pp. H1378-H1387 ◽  
Author(s):  
James W. E. Rush ◽  
James R. Turk ◽  
M. Harold Laughlin

Vascular oxidative stress contributes to endothelial dysfunction. Aerobic exercise training improves vascular function. The purpose of this study was to test the hypothesis that exercise training would improve the balance of antioxidant to prooxidant enzymes and reduce markers of oxidative stress in aortic endothelial cells (AEC). Female Yucatan miniature pigs either remained sedentary (SED) or were exercise trained (EX) for 16–19 wk. EX pigs had increased AEC SOD-1 protein levels and Cu/Zn SOD activity of the whole aorta compared with SED pigs. Protein levels of other antioxidant enzymes (SOD-2, catalase) were not affected by exercise training. Protein levels of p67phox, a subunit of the prooxidant enzyme NAD(P)H oxidase, were reduced in EX vs. SED AEC. These EX adaptations were associated with lower AEC malondialdehyde levels and decreased phosphorylation of ERK-1/2. Endothelial nitric oxide synthase protein, protein nitrotyrosine content, and heme oxygenase-1 protein were not different in EX vs. SED pigs. We conclude that chronic aerobic exercise training influenced both antioxidant and prooxidant enzymes and decreased indexes of oxidative stress in AEC. These adaptations may contribute to improved endothelial function with exercise training.


1989 ◽  
Vol 63 (3) ◽  
pp. 254-256 ◽  
Author(s):  
James O. Hill ◽  
John Thiel ◽  
Patricia A. Heller ◽  
Clyde Markon ◽  
Gerald Fletcher ◽  
...  

1993 ◽  
Vol 25 (Supplement) ◽  
pp. S79
Author(s):  
L. Panton ◽  
L. Garzarella ◽  
S. McCue ◽  
G. Guillen ◽  
L. Williams ◽  
...  

Author(s):  
Lukas Daniel Trachsel ◽  
Maxime Boidin ◽  
Christine Henri ◽  
Annik Fortier ◽  
Julie Lalongé ◽  
...  

We aimed to compare cardiopulmonary exercise test (CPET) parameters, cardiac adaptations and proportion of responders after different aerobic training programs amongst women and men with coronary heart disease (CHD). Patients with CHD were evaluated with a CPET and echocardiography before and after 3 month of aerobic exercise training. V̇O2 peak exercise training response was assessed according to the median V̇O2 peak change post vs. pre-training in the whole cohort (stratification non-/low-responders (NLRes) vs. high-responders) and normalized for lean body mass (LBM). Eighty three CHD patients were included (19 women, 64 men), (27 patients with interval, 19 with continuous and 37 with a combination). V̇O2 peak, peak work load normalized for LBM, pulmonary (i.e. ventilation and OUES) and O2 pulse were significantly lower in women vs. men.These parameters improved similarly with training in both sexes (p<0.05). There were no differences in the proportion of NLRes among women and men with CHD (7/19 or 37% vs. 35/64 or 55%, p=0.1719). Left ventricular ejection fraction and mean peak early diastolic mitral annulus velocity improved similarly with training in both sexes (p<0.05). Women and men with CHD have a similar exercise training response regarding key CPET, echocardiographic parameters. The proportion of responders is similar. ClinicalTrials.gov: NCT03414996, NCT02048696, NCT03443193 Novelty: Cardiopulmonary adaptations to exercise training is similar among CHD men and women Proportion of V̇O2 peak non-/low-/high-responders is similar in CHD men and women LV systolic (LVEF) and diastolic (e’) function improved similarly after exercise training in CHD men and women


1989 ◽  
Vol 44 (5) ◽  
pp. M147-M157 ◽  
Author(s):  
J. A. Blumenthal ◽  
C. F. Emery ◽  
D. J. Madden ◽  
L. K. George ◽  
R. E. Coleman ◽  
...  

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