Thermal Conductivity and Thermal Diffusivity of Biomaterials: A Simultaneous Measurement Technique

1977 ◽  
Vol 99 (3) ◽  
pp. 148-154 ◽  
Author(s):  
T. A. Balasubramaniam ◽  
H. F. Bowman
Keyword(s):  
Thermal Conductivity ◽  
Thermal Properties ◽  
Thermal Diffusivity ◽  
Measurement Technique ◽  
Thermal Model ◽  
In Vitro Measurements ◽  
Made In

A technique is presented for the simultaneous determination of thermal conductivity and thermal diffusivity of biomaterials. Measurements are derived from the transient power supplied to a thermistor probe operated in a self-heated mode. The thermal properties are extracted through the use of an appropriate thermal model. Thermal conductivity is determined through a simple algebraic equation. Thermal diffusivity is determined from a convenient set of nondimensionalized curves. The technique can be used in vivo and in vitro. Measurements can be made in sample volumes of less than 1 cc in less than 30 s.

The Simultaneous Measurement of Thermal Conductivity, Thermal Diffusivity, and Perfusion in Small Volumes of Tissue

1984 ◽  
Vol 106 (3) ◽  
pp. 192-197 ◽  
Author(s):  
J. W. Valvano ◽  
J. T. Allen ◽  
H. F. Bowman
Keyword(s):  
Thermal Conductivity ◽  
Thermal Properties ◽  
Thermal Diffusivity ◽  
Tissue Perfusion ◽  
Effective Thermal Diffusivity ◽  
Liver Preparation ◽  
Improved Technique ◽  
Power Response

An improved technique is presented for the “in-vivo” determination of thermal conductivity, thermal diffusivity, and perfusion using a self-heated spherical thermistor probe. In the presence of flow, solution of the time-dependent, probe-tissue coupled thermal model allows the measurement of “effective” thermal conductivity and “effective” thermal diffusivity, which represent the thermal properties of the perfused tissue. Perfusion can be quantified from both “effective” thermal properties. In the presence of flow, it has been shown that the transient power response does not follow t−1/2 as has been previously assumed. An isolated rat liver preparation has been developed to validate the measurement technique. Radioactive microspheres are used to determine the true perfusion from the total collected hepatic vein flow. Experimental data demonstrates the ability to quantify perfusion in small volumes of tissue.

Thermal Properties of Thin Metallic Layer Deposited on Insulators: Effect of the Interface on the Independent Determination of the Thermal Diffusivity and Conductivity of the Layer

2008 ◽  
Author(s):  
Danie`le Fournier ◽  
Jean Paul Roger ◽  
Christian Fretigny
Keyword(s):  
Thermal Conductivity ◽  
Thermal Properties ◽  
Thermal Diffusivity ◽  
Thermal Resistance ◽  
Thermal Contact ◽  
Heat Diffusion ◽  
Metallic Layer ◽  
Good Thermal Contact ◽  
Lateral Heat

Lateral heat diffusion thermoreflectance is a very powerful tool for determining directly the thermal diffusivity of layered structures. To do that, experimental data are fitted with the help of a heat diffusion model in which the ratio between the thermal conductivity k and the thermal diffusivity D of each layer is fixed, and the thermal properties of the substrate are known. We have shown in a previous work that it is possible to determine independently the thermal diffusivity and the thermal conductivity of a metallic layer deposited on an insulator, by taking into consideration all the data obtained at different modulation frequencies. Moreover, it is well known that to prevent a lack of adhesion of a gold film deposited on substrates like silica, an intermediate very thin (Cr or Ti) layer is deposited to assure a good thermal contact. We extend our previous work: the asymptotic behaviour determination of the surface temperature wave at large distances from the modulated point heat source for one layer deposited on the substrate to the two layers model. In this case (very thin adhesion coating whose thermal properties and thickness are known), it can be establish that the thermal diffusivity and the thermal conductivity of the top layer can still be determined independently. It is interesting to underline that the calculus can also be extended to the case of a thermal contact resistance which has often to be taken into account between two solids. We call thermal resistance a very thin layer exhibiting a very low thermal conductivity. In this case, the three parameters we have to determine are the thermal conductivity and the thermal diffusivity of the layer and the thermal resistance. We will show that, in this case, the thermal conductivity of the layer is always obtained independently of a bound of the couple thermal resistance – thermal diffusivity, the thermal diffusivity being under bounded and the thermal resistance lower bounded. Experimental results on thin gold layers deposited on silica with and without adhesion layers are presented to illustrate the method. Discussions on the accuracy will also be presented.

Issues with the Assay of Factor VIII Activity in Plasma and Factor VIII Concentrates

2000 ◽  
Vol 84 (12) ◽  
pp. 942-948 ◽  
Author(s):  
Henry Kingdon ◽  
Kenneth Mann ◽  
Gilbert White ◽  
Roger Lundblad
Keyword(s):  
Factor Viii ◽  
Hemophilia A ◽  
Coagulation Factors ◽  
Chromogenic Substrate ◽  
In Vitro Measurements ◽  
Factor Viii Concentrates ◽  
The One

SummaryA review of the literature suggests that assays accurate for the determination of factor VIII in plasma samples may not necessarily retain this accuracy when used for the determination of factor VIII in high-purity factor VIII concentrates such as Hemofil ® M. Review of assay data suggests that it is imperative to obtain maximal activation of the factor VIII in the sample with thrombin when using an assay system of isolated coagulation factors such as the two-stage assay or the various chromogenic substrate assays. Based on a combination of ease and reproducibility of performance and correlation of in vivo and in vitro measurements, it is recommended that the one-stage activated partial thromboplastin time performed with plasma from an individual with severe hemophilia A be used for the measurement of factor VIII potency. Chromogenic substrate assays can be used if care is taken to assure optimal activation of factor VIII by thrombin in the assay and the presence of sufficient factor IXa, phospholipid and calcium ions to stabilize factor Villa during the assay process.

scholarly journals DETERMINATION OF THERMAL PROPERTIES OF COFFEE BEANS AT DIFFERENT DEGREES OF ROASTING

2018 ◽  
Vol 13 (4) ◽  
pp. 498
Author(s):  
Danilo Barbosa Cardoso ◽  
Ednilton Tavares de Andrade ◽  
Renso Alfredo Aragón Calderón ◽  
Mariane Helena Sanches Rabelo ◽  
Camila De Almeida Dias ◽  
...  
Keyword(s):  
Thermal Conductivity ◽  
Thermal Properties ◽  
Thermal Diffusivity ◽  
Specific Heat ◽  
Infinite Cylinder ◽  
Element Analysis ◽  
Heating Source ◽  
Mixing Method ◽  
Cylinder Method

<p>The aim of this study was to determine the main thermal properties of the granular mass of coffee (specific heat, thermal conductivity, and thermal diffusivity) for different degrees of roasting, as well as to model and simulate thermal conductivity at different degrees of roasting. For determination of specific heat, the mixing method was used, and for thermal conductivity, the theoretically infinite cylinder method with a central heating source. Thermal diffusivity was simulated algebraically using the results of the properties cited above and of the apparent specific mass of the product. Thermal conductivity was also simulated and optimized through finite element analysis software. At darker roasting, there was an increase in specific heat and a reduction in thermal conductivity and thermal diffusivity. Comparing thermal conductivity determined in relation to simulated and optimized conductivity, the mean relative error was 1.02%, on average.</p>

Hepatic clearance of indocyanine in the dog

1960 ◽  
Vol 198 (4) ◽  
pp. 881-885 ◽  
Author(s):  
William J. Stekiel ◽  
John P. Kampine ◽  
Edward F. Banaszak ◽  
James J. Smith
Keyword(s):  
Experimental Error ◽  
Single Injection ◽  
Hepatic Clearance ◽  
Sodium Pentobarbital ◽  
Two Factors ◽  
Peripheral Arterial ◽  
Made In

The clearance and extraction by the liver of the dye, indocyanine green, was studied in dogs anesthetized with sodium pentobarbital (30 mg/kg). A simultaneous comparison ‘ in vivo’ indicated that within experimental error indocyanine space equals Evans blue space. Additional in vitro experiments suggest that indocyanine space is a reasonably satisfactory measure of plasma volume. Adequate mixing of the injected dye occurs within 2–3 minutes after injection. From 2 to 20 minutes after injection, the peripheral arterial and hepatic venous decay slopes are logarithmic and easily analyzable. Right hepatic vein concentrations of indocyanine were consistently higher (3.3%) than those of the left. Most of the assumptions made in the clearance-extraction principle of measuring hepatic flow are valid. At least two factors, the obtaining of representative hepatic venous samples and determination of true extraction ratio (because of hepatic circulatory time) represent ill-defined sources of error. The soundness of the clearance-extraction principle and unique characteristics of indocyanine make the single injection method a potentially useful tool for study of hepatic blood flow.

scholarly journals Determination of Some Selected Thermal Properties of Pumpkin Seeds (Cucurbita pepo)

2021 ◽  
Vol 25 (4) ◽  
pp. 599-604
Author(s):  
M.O. Sunmonu ◽  
M.M. Odewole ◽  
O.A. Adeyinka ◽  
M.S. Sanusi ◽  
S.O. Musa
Keyword(s):  
Thermal Conductivity ◽  
Thermal Properties ◽  
Thermal Diffusivity ◽  
Moisture Content ◽  
Specific Heat ◽  
Average Moisture Content ◽  
Pumpkin Seed ◽  
C Value ◽  
Pumpkin Seeds

In this study, some selected thermal properties (specific heat, thermal conductivity and thermal diffusivity) in the moisture content range of 5.0-5.6% or green and 4.80 – 5.20% for white varieties of pumpkin seeds were determined. The specific heat was measured using mixture method while the thermal conductivity was measured by transient technique using the heat line source. The green pumpkin seed has average moisture content of 5.2% higher than moisture content of white pumpkin seed of average 4.8%. The average specific heat values of green pumpkin seed are 6.171kJ/kgK and white pumpkin seed 4.327kJ/kgK. The thermal conductivity values for white pumpkin seed ranged from 0.074 to 0.288 W/m°C while that for green pumpkin seed ranged from 0.079 to 0.433 W/m°C. The thermal diffusivity values for green pumpkin ranged from 0.0011 to 0.06 m2/s while that for white pumpkin seed ranged from 0.01 to 0.06 m2/s. It was concluded that the higher the moisture content (5.2%) the higher the value of specific heat of seed (6.171kJ/kgK). It can also be concluded that the thermal conductivity (0.079 to 0.433 W/m°C) value is higher with high moisture content (5.2%).

A Molecular Approach to Immunoscintigraphy: A Study of the T-Antigen Conformation on the Surface of Tumors

1987 ◽  
Vol 26 (01) ◽  
pp. 1-6 ◽  
Author(s):  
S. Selvaraj ◽  
M. R. Suresh ◽  
G. McLean ◽  
D. Willans ◽  
C. Turner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Cell ◽  
T Antigen ◽  
Human Carcinomas ◽  
Animal Tumor ◽  
Synthetic Antigens

The role of glycoconjugates in tumor cell differentiation has been well documented. We have examined the expression of the two anomers of the Thomsen-Friedenreich antigen on the surface of human, canine and murine tumor cell membranes both in vitro and in vivo. This has been accomplished through the synthesis of the disaccharide terminal residues in both a and ß configuration. Both entities were used to generate murine monoclonal antibodies which recognized the carbohydrate determinants. The determination of fine specificities of these antibodies was effected by means of cellular uptake, immunohistopathology and immunoscintigraphy. Examination of pathological specimens of human and canine tumor tissue indicated that the expressed antigen was in the β configuration. More than 89% of all human carcinomas tested expressed the antigen in the above anomeric form. The combination of synthetic antigens and monoclonal antibodies raised specifically against them provide us with invaluable tools for the study of tumor marker expression in humans and their respective animal tumor models.

Storage of Human Blood Platelets

1974 ◽  
Vol 32 (02/03) ◽  
pp. 405-416 ◽  
Author(s):  
M. R Hardeman ◽  
Carina J L. Heynens
Keyword(s):  
Storage Temperature ◽  
Platelet Rich Plasma ◽  
Blood Platelets ◽  
Storage Period ◽  
Serotonin Uptake ◽  
Hypotonic Shock ◽  
Glycolytic Intermediates

SummaryStorage experiments were performed at 4°, 25° and 37° C with platelet-rich plasma under sterile conditions. In some experiments also the effect of storing platelets at 4° C in whole blood was investigated.Before, during and after three days of storage, the platelets were tested at 37° C for their serotonin uptake and response to hypotonic shock. In addition some glycolytic intermediates were determined.A fair correlation was noticed between the serotonin uptake and hypotonic shock experiments. Both parameters were best maintained at 25° C. Also platelet counting, performed after the storage period, indicated 25° C as the best storage temperature. Determination of glycolytic intermediates did not justify any conclusion regarding the optimal storage temperature. Of the various anticoagulants studied, ACD and heparin gave the best results as to the serotonin uptake and hypotonic shock response, either with fresh or stored platelets. The use of EDTA resulted in the lowest activity, especially after storage.The results of these storage experiments in vitro, correspond well with those in vivo reported in the literature.

Sign in / Sign up

Export Citation Format

Share Document