scholarly journals Pronation–Supination Motion Is Altered in a Rat Model of Post-Traumatic Elbow Contracture

2017 ◽  
Vol 139 (7) ◽  
Author(s):  
Chelsey L. Dunham ◽  
Ryan M. Castile ◽  
Aaron M. Chamberlain ◽  
Leesa M. Galatz ◽  
Spencer P. Lake
Keyword(s):  
Animal Model ◽  
Soft Tissues ◽  
Lateral Collateral Ligament ◽  
Human Condition ◽  
Joint Contracture ◽  
Elbow Injury ◽  
Flexion Extension ◽  
Post Traumatic ◽  
Elbow Contracture ◽  
Anterior Capsulotomy

The elbow joint is highly susceptible to joint contracture, and treating elbow contracture is a challenging clinical problem. Previously, we established an animal model to study elbow contracture that exhibited features similar to the human condition including persistent decreased range of motion (ROM) in flexion–extension and increased capsule thickness/adhesions. The objective of this study was to mechanically quantify pronation–supination in different injury models to determine if significant differences compared to control or contralateral persist long-term in our animal elbow contracture model. After surgically inducing soft tissue damage in the elbow, Injury I (anterior capsulotomy) and Injury II (anterior capsulotomy with lateral collateral ligament transection), limbs were immobilized for 6 weeks (immobilization (IM)). Animals were evaluated after the IM period or following an additional 6 weeks of free mobilization (FM). Total ROM for pronation–supination was significantly decreased compared to the uninjured contralateral limb for both IM and FM, although not different from control limbs. Specifically, for both IM and FM, total ROM for Injury I and Injury II was significantly decreased by ∼20% compared to contralateral. Correlations of measurements from flexion–extension and pronation–supination divulged that FM did not affect these motions in the same way, demonstrating that joint motions need to be studied/treated separately. Overall, injured limbs exhibited persistent motion loss in pronation–supination when comparing side-to-side differences, similar to human post-traumatic joint contracture. Future work will use this animal model to study how elbow periarticular soft tissues contribute to contracture.

scholarly journals Surgical treatment for terrible triad injury of the elbow with anteromedial coronoid fracture through a combined surgical approach

2018 ◽  
Vol 46 (8) ◽  
pp. 3053-3064 ◽  
Author(s):  
Guanyi Liu ◽  
Jingen Hu ◽  
Weihu Ma ◽  
Ming Li ◽  
Rongming Xu ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Surgical Approach ◽  
Lateral Collateral Ligament ◽  
Surgical Approaches ◽  
Terrible Triad ◽  
Coronoid Fracture ◽  
Flexion Extension ◽  
Post Traumatic ◽  
Coronoid Fractures ◽  
The Mean

Summary Objective To report the results of the surgical treatment of terrible triad injury with anteromedial coronoid fracture through a combined surgical approach. Methods This retrospective study evaluated data from patients who underwent surgery to repair terrible triad injuries and anteromedial coronoid fractures. Surgical treatment involved radial head repair or replacement, medial and lateral collateral ligament repair, and coronoid fracture fixation through combined approaches. Evaluations were performed using the Mayo Elbow Performance Score (MEPS) and anteroposterior and lateral radiographs of the elbow. Results Twenty-two patients (15 males, seven females; mean ± SD age, 47.5 ± 11.4 years) were enrolled in this study. Fracture union and concentric reduction of both the ulnotrochlear and radiocapitellar articulations were achieved in all patients. The mean ± SD follow-up was 31.6 ± 11.9 months. The mean ± SD arc of flexion–extension was 110.3° ± 26.3° and arc of forearm rotation was 139.5° ± 17.1°. The mean ± SD MEPS was 88.1 ± 12.2 points, with results classified as excellent in eight elbows, good in ten, and fair in four. Six patients had radiographic signs of post-traumatic arthritis. Three patients required secondary surgeries. Conclusion Combined surgical approaches can be considered for the treatment of terrible triad injuries in association with anteromedial coronoid fractures.

Increased volume and collagen crosslinks drive soft tissue contribution to post‐traumatic elbow contracture in an animal model

2020 ◽  
Author(s):  
Chelsey L. Dunham ◽  
Heiko Steenbock ◽  
Jürgen Brinckmann ◽  
Alex J. Reiter ◽  
Ryan M. Castile ◽  
...  
Keyword(s):  
Animal Model ◽  
Soft Tissue ◽  
Collagen Crosslinks ◽  
Post Traumatic ◽  
Elbow Contracture

Recent advances in animal model experimentation in autism research

2013 ◽  
Vol 26 (5) ◽  
pp. 264-271 ◽  
Author(s):  
Mousumi Tania ◽  
Md. Asaduzzaman Khan ◽  
Kun Xia
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Human Condition ◽  
Behavioral Alterations ◽  
Important Place ◽  
Adult Mice ◽  
Recent Advances ◽  
Model Study ◽  
Disease Biology ◽  
Animal Model Study

ObjectiveAutism, a lifelong neuro-developmental disorder is a uniquely human condition. Animal models are not the perfect tools for the full understanding of human development and behavior, but they can be an important place to start. This review focused on the recent updates of animal model research in autism.MethodsWe have reviewed the publications over the last three decades, which are related to animal model study in autism.ResultsAnimal models are important because they allow researchers to study the underlying neurobiology in a way that is not possible in humans. Improving the availability of better animal models will help the field to increase the development of medicines that can relieve disabling symptoms. Results from the therapeutic approaches are encouraging remarkably, since some behavioral alterations could be reversed even when treatment was performed on adult mice. Finding an animal model system with similar behavioral tendencies as humans is thus vital for understanding the brain mechanisms, supporting social motivation and attention, and the manner in which these mechanisms break down in autism. The ongoing studies should therefore increase the understanding of the biological alterations associated with autism as well as the development of knowledge-based treatments therapy for those struggling with autism.ConclusionIn this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals.

Effect of Heat in Increasing the Range of Knee Motion After the Development of a Joint Contracture: An Experiment With an Animal Model

2006 ◽  
Vol 87 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Mariko Usuba ◽  
Yutaka Miyanaga ◽  
Shumpei Miyakawa ◽  
Toru Maeshima ◽  
Yoshio Shirasaki
Keyword(s):  
Animal Model ◽  
Joint Contracture ◽  
Knee Motion

scholarly journals ENT trauma in children: causes, frequency and characteristics in different periods of childhood

2020 ◽  
Vol 19 (6) ◽  
pp. 94-101
Author(s):  
E. Yu. Radtsig ◽  
◽  
M. M. Evsikova ◽  
M. A. Varavina ◽  
◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Soft Tissues ◽  
Traumatic Events ◽  
Frequency Of Occurrence ◽  
External Nose ◽  
Post Traumatic

Numerous injuries (and their treatment) have been encountered since the very beginning of the development of human civilization and remain one of the most significant problems in our time, since the frequency of injuries in general (and of ENT organs in particular) does not tend to decrease either in children or adults. ENT injuries are in fourth place in terms of emergency appeal rates. The most common injury to the maxillofacial area is a fracture of the skeleton of the nose. The article presents data on the frequency of occurrence of this pathology and describes the features of the causes that caused it in different periods of childhood, presents an algorithm for managing patients. The role of homeopathic arnica-containing remedies (Arnigel®) in the conservative treatment of reactive post-traumatic events from the soft tissues of the external nose is shown.

scholarly journals Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

2019 ◽  
Vol 7 (S3) ◽  
pp. S81-S81
Author(s):  
Quante Singleton ◽  
Santul Bapat ◽  
Sadanand Fulzele
Keyword(s):  
Animal Model ◽  
Post Traumatic

Finite Element Model of the Human Knee Joint to Study Tibio-Femoral Contact Mechanics

2000 ◽  
Author(s):  
Tammy Haut Donahue ◽  
Maury L. Hull ◽  
Mark M. Rashid ◽  
Christopher R. Jacobs
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Degrees Of Freedom ◽  
Soft Tissues ◽  
Element Model ◽  
Human Knee ◽  
Human Knee Joint ◽  
Solid Models ◽  
Flexion Extension ◽  
A New Technique

Abstract A finite element model of the tibio-femoral joint in the human knee was created using a new technique for developing accurate solid models of soft tissues (i.e. cartilage and menisci). The model was used to demonstrate that constraining rotational degrees of freedom other than flexion/extension when the joint is loaded in compression markedly affects the load distribution between the medial and lateral sides of the joint. The model also was used to validate the assumption that the bones can be treated as rigid.

Management of recurrent post-traumatic seroma of thigh (Morel-Lavallée lesion) by percutaneous aspiration and sclerotherapy using tetracyclines (PAST)

2021 ◽  
Vol 14 (1) ◽  
pp. e238804
Author(s):  
Arunesh Gupta ◽  
Vineet Kumar ◽  
Apurva Agarwal ◽  
Aneesh Suresh
Keyword(s):  
Early Diagnosis ◽  
Conservative Management ◽  
Bacterial Contamination ◽  
Soft Tissues ◽  
Successful Outcome ◽  
Serous Fluid ◽  
Percutaneous Aspiration ◽  
Post Traumatic ◽  
Open Debridement ◽  
Definitive Management

Morel-Lavallée lesion is a chronic, recurrent collection of serous fluid in the soft tissues and usually occurs following injury. The most common sites are thigh, hip and pelvic region. This presents as a local or diffuse swelling and may cause discomfort to the patient besides being a potential site for bacterial contamination. So, early diagnosis and timely management is crucial for an early and successful outcome. The investigation modality of choice for diagnosis of these lesions is MRI. Definitive management ranges from percutaneous aspiration with or without sclerotherapy to open debridement and irrigation. Although recurrences are common with conservative management, it can be minimised with judicious use of sclerotherapy.

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