Comparison of Human Surrogate Responses in Underbody Blast Loading Conditions

2020 ◽  
Vol 142 (9) ◽  
Author(s):  
K. Ott ◽  
D. Drewry ◽  
M. Luongo ◽  
J. Andrist ◽  
R. Armiger ◽  
...  
Keyword(s):  
Vertical Direction ◽  
Whole Body ◽  
Matched Pair ◽  
Loading Conditions ◽  
Occupant Safety ◽  
Vertical Loading ◽  
Impact Biomechanics ◽  
Biomechanical Response ◽  
Hybrid Iii

Abstract Impact biomechanics research in occupant safety predominantly focuses on the effects of loads applied to human subjects during automotive collisions. Characterization of the biomechanical response under such loading conditions is an active and important area of investigation. However, critical knowledge gaps remain in our understanding of human biomechanical response and injury tolerance under vertically accelerated loading conditions experienced due to underbody blast (UBB) events. This knowledge gap is reflected in anthropomorphic test devices (ATDs) used to assess occupant safety. Experiments are needed to characterize biomechanical response under UBB relevant loading conditions. Matched pair experiments in which an existing ATD is evaluated in the same conditions as a post mortem human subject (PMHS) may be utilized to evaluate biofidelity and injury prediction capabilities, as well as ATD durability, under vertical loading. To characterize whole body response in the vertical direction, six whole body PMHS tests were completed under two vertical loading conditions. A series of 50th percentile hybrid III ATD tests were completed under the same conditions. Ability of the hybrid III to represent the PMHS response was evaluated using a standard evaluation metric. Tibial accelerations were comparable in both response shape and magnitude, while other sensor locations had large variations in response. Posttest inspection of the hybrid III revealed damage to the pelvis foam and skin, which resulted in large variations in pelvis response. This work provides an initial characterization of the response of the seated hybrid III ATD and PMHS under high rate vertical accelerative loading.

Comparison of Hybrid-III and Postmortem Human Surrogate Response to Simulated Underbody Blast Loading

2015 ◽  
Vol 137 (5) ◽  
Author(s):  
Ann Marie Bailey ◽  
John J. Christopher ◽  
Robert S. Salzar ◽  
Frederick Brozoski
Keyword(s):  
Human Body ◽  
High Rate ◽  
Whole Body ◽  
Loading Conditions ◽  
Test Device ◽  
Vertical Loading ◽  
Military Vehicle ◽  
Acceleration Data ◽  
Hybrid Iii ◽  
Chaotic Nature

Response of the human body to high-rate vertical loading, such as military vehicle underbody blast (UBB), is not well understood because of the chaotic nature of such events. The purpose of this research was to compare the response of postmortem human surrogates (PMHS) and the Hybrid-III anthropomorphic test device (ATD) to simulated UBB loading ranging from 100 to 860 g seat and floor acceleration. Data from 13 whole body PMHS tests were used to create response corridors for vertical loading conditions for the pelvis, T1, head, femur, and tibia; these responses were compared to Hybrid-III responses under matched loading conditions.

An Experimental and Numerical Study of Hybrid III Dummy Response to Simulated Underbody Blast Impacts

2017 ◽  
Vol 139 (12) ◽  
Author(s):  
Karthik Somasundaram ◽  
Anil Kalra ◽  
Don Sherman ◽  
Paul Begeman ◽  
King H. Yang ◽  
...  
Keyword(s):  
High Speed ◽  
Numerical Study ◽  
High Stress ◽  
Fe Model ◽  
Loading Conditions ◽  
Stress Concentrations ◽  
Vertical Loading ◽  
Laboratory Setup ◽  
Body Regions ◽  
Hybrid Iii

Anthropometric test devices (ATDs) such as the Hybrid III dummy have been widely used in automotive crash tests to evaluate the risks of injury at different body regions. In recent years, researchers have started using automotive ATDs to study the high-speed vertical loading response caused by underbody blast impacts. This study analyzed the Hybrid III dummy responses to short-duration, large magnitude vertical accelerations in a laboratory setup. Two unique test conditions were investigated using a horizontal sled system to simulate underbody blast loading conditions. The biomechanical responses in terms of pelvis acceleration, chest acceleration, lumbar spine force, head accelerations, and neck forces were measured. Subsequently, a series of finite element (FE) analyses were performed to simulate the physical tests. The correlation between the Hybrid III test and numerical model was evaluated using the correlation and analysis (cora) version 3.6.1. The score for the Wayne State University (WSU) FE model was 0.878 and 0.790 for loading conditions 1 and 2, respectively, in which 1.0 indicated a perfect correlation between the experiment and the simulated response. With repetitive vertical impacts, the Hybrid III dummy pelvis showed a significant increase in peak acceleration accompanied by a rupture of the pelvis foam and flesh. The revised WSU Hybrid III model indicated high stress concentrations at the same location, providing a possible explanation for the material failure in actual Hybrid III tests.

Kinematic and Biomechanical Response of Post-Mortem Human Subjects Under Various Pre-Impact Postures to High-Rate Vertical Loading Conditions

2020 ◽  
Author(s):  
Lauren Wood Zaseck ◽  
Anne C Bonifas ◽  
Carl S Miller ◽  
Nichole Ritchie Orton ◽  
Matthew P Reed ◽  
...  
Keyword(s):  
Human Subjects ◽  
High Rate ◽  
Post Mortem ◽  
Loading Conditions ◽  
Vertical Loading ◽  
Biomechanical Response

scholarly journals Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vidya Chandrasekaran ◽  
Giada Carta ◽  
Daniel da Costa Pereira ◽  
Rajinder Gupta ◽  
Cormac Murphy ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Retinoic Acid Receptor ◽  
Renal Proximal Tubule ◽  
Whole Body ◽  
Proper Function ◽  
Genome Wide ◽  
Glomerular Filtrate ◽  
Proximal Tubular ◽  
Induced Pluripotent

AbstractThe renal proximal tubule is responsible for re-absorption of the majority of the glomerular filtrate and its proper function is necessary for whole-body homeostasis. Aging, certain diseases and chemical-induced toxicity are factors that contribute to proximal tubule injury and chronic kidney disease progression. To better understand these processes, it would be advantageous to generate renal tissues from human induced pluripotent stem cells (iPSC). Here, we report the differentiation and characterization of iPSC lines into proximal tubular-like cells (PTL). The protocol is a step wise exposure of small molecules and growth factors, including the GSK3 inhibitor (CHIR99021), the retinoic acid receptor activator (TTNPB), FGF9 and EGF, to drive iPSC to PTL via cell stages representing characteristics of early stages of renal development. Genome-wide RNA sequencing showed that PTL clustered within a kidney phenotype. PTL expressed proximal tubular-specific markers, including megalin (LRP2), showed a polarized phenotype, and were responsive to parathyroid hormone. PTL could take up albumin and exhibited ABCB1 transport activity. The phenotype was stable for up to 7 days and was maintained after passaging. This protocol will form the basis of an optimized strategy for molecular investigations using iPSC derived PTL.

Characterization of the morning transition from downslope to upslope winds and its connection with the nocturnal inversion breakup at the foot of a gentle slope

2021 ◽  
Author(s):  
Sofia Farina ◽  
Dino Zardi ◽  
Silvana Di Sabatino ◽  
Mattia Marchio ◽  
Francesco Barbano
Keyword(s):  
Salt Lake ◽  
Vertical Direction ◽  
Blow Down ◽  
Physical Mechanisms ◽  
Morning Transition ◽  
Thermally Driven ◽  
Slope Wind ◽  
Slope Flow ◽  
Nocturnal Inversion

<p>Thermally driven winds observed in complex terrain are characterized by a daily cycle dominated by two main phases: a diurnal phase in which winds blow upslope (anabatic), and a nocturnal one in which they revert their direction and blow down slope (katabatic). This alternating pattern also implies two transition phases, following sunrise and sunset respectively. </p><p>Here we study the up-slope component of the slope wind with a focus on the morning transition based on from the MATERHORN experiment, performed in Salt Lake Desert (Utah) between Fall 2012 and Spring 2013. </p><p>The analysis develops along three main paths of investigation. The first one is the selection of the suitable conditions for the study of the diurnal component and the characterization of the morning transition. The second one focuses on the deep analysis of the erosion of the nocturnal inversion at the foot of the slope in order to investigate the physical mechanisms driving it. And the third one consists in the comparison between the experimental data and the results of an analytical model (Zardi and Serafin, 2015). The study of the morning transition in the selected case studies allowed its characterization in terms of the relation with the solar radiation cycle, in terms of its seasonality and in terms of its propagation along the slope and along the vertical direction. Most of the results of this investigation are related to the identification of the main mechanisms of erosion of the nocturnal inversion at the foot of the slope and to its role to the beginning of the transition itself. Finally, it is shown how the above model can fairly reproduce the cycle between anabatic and katabatic flow and their intensity.</p><p>Zardi, D. and S. Serafin, 2015: An analytic solution for daily-periodic thermally-driven slope flow. Quart. J. Roy. Meteor. Soc., 141, 1968–1974.</p>

Blast Mitigation Seat Analysis: Evaluation of Lumbar Compression Data Trends in 5th Percentile Female Anthropomorphic Test Device Performance Compared to 50th Percentile Male Anthropomorphic Test Device in Drop Tower Testing

2016 ◽  
Author(s):  
Kelly Bosch
Keyword(s):  
Lumbar Spine ◽  
Vertical Direction ◽  
Drop Tower ◽  
Blast Mitigation ◽  
Test Device ◽  
Military Population ◽  
Data Set ◽  
System Survivability ◽  
Blast Energy ◽  
Hybrid Iii

Although blast mitigation seats are historically designed to protect the 50th percentile male occupant based on mass, the scope of the occupant centric platform (OCP) Technology Enabled Capability Demonstration (TEC-D) within the U.S. Army Tank Automotive Research Development Engineering Center (TARDEC) Ground System Survivability has been expanded to encompass lighter and heavier occupants which represents the central 90th percentile of the military population. A series of drop tower tests were conducted on twelve models of blast energy-attenuating (EA) seats to determine the effects of vertical accelerative loading on ground vehicle occupants. Two previous technical publications evaluated specific aspects of the results of these drop tower tests on EA seats containing the three sizes of anthropomorphic test devices (ATDs) including the Hybrid III 5th percentile female, the Hybrid III 50th percentile male, and the Hybrid III 95th percentile male. The first publication addressed the overall trends of the forces, moments, and accelerations recorded by the ATDs when compared to Injury Assessment Reference Values (IARVs), as well as validating the methodology used in the drop tower evaluations1. Review of ATD data determined that the lumbar spine compression in the vertical direction could be used as the “go/no-go” indicator of seat performance. The second publication assessed the quantitative effects of Personal Protective Equipment (PPE) on the small occupant, as the addition of a helmet and Improved Outer Tactical Vest (IOTV) with additional gear increased the weight of the 5th percentile female ATD more than 50%2. Comparison of the loading data with and without PPE determined that the additional weight of PPE increased the overall risk of compressive injury to the lumbar and upper neck of the small occupant during an underbody blast event. Using the same data set, this technical paper aimed to evaluate overall accelerative loading trends of the 5th percentile female ATD when compared to those of the 50th percentile male ATD in the same seat and PPE configuration. This data trend comparison was conducted to gain an understanding of how seat loading may differ with a smaller occupant. The focus of the data analysis centered around the lumbar spine compression, as this channel was the most likely to exceed the IARV limit for the 5th percentile female ATD. Based on the previous analysis of this data set, the lightest occupant trends showed difficulty in protecting against lumbar compression injuries with respect to the 5th percentile female’s IARV, whereas the larger occupants experienced fewer issues in complying with their respective IARVs for lumbar compression. A review of pelvis acceleration was also conducted for additional kinetic insight into the motion of the ATDs as the seat strokes. This analysis included a review of how the weight and size of the occupant may affect the transmission of forces through a stroking seat during the vertical accelerative loading impulse.

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