<p>Coastal flooding due to tropical cyclones (TC) is one of the world&#8217;s most threatening hazards.&#160;The potential increase in the probability of these events in the future, due to climate change, necessitates the more accurate simulation of their potential hazard and resulting risks.&#160;This contribution is a step of a MOSAIC (MOdelling Sea level And Inundation for Cyclones) project that aims at developing and validating a computationally efficient, scalable, framework for large-scale flood risk assessment, combining cutting-edge disciplinary science and eScience technologies. As the first step, we develop a computationally efficient method for more accurately simulating current and future TC hazard and risk, by incorporating large datasets of tropical cyclones within the Global Tide and Surge Model (GTSM).&#160;The starting point is simulating the spatially explicit extreme sea levels for a large number of synthetic TCs. The difficulty lies in high computational time required for running GTSM models, as with duration of one simulation running on 24 cores of 5 days ( for 1yr). Until present each TC was simulated separately*, which is not feasible when modelling thousands of TC events.&#160;Here we present the&#160;development of an algorithm for the spatio-temporal optimization of the placing of TCs within GTSM in order to allow optimal use of the computational resources. This can be achieved because&#160;the region of influence of a particular TC in the model is limited in space and time (e.g. a TC making&#160;landfall in Florida will not materially affect water levels near New York).&#160;&#160;This will enable running a large number of TCs in one simulation and will significantly reduce the required total computation time. We investigate a large range of parameters, such as distance between cyclones, time to the landfall, category of cyclone, and others, to optimize the distribution of TC within a single model run. We demonstrate a significant speedup relative to the sequential running of the cyclones within a single simulation.</p><p>*Muis, S., Verlaan, M., Winsemius, H. C., Aerts, J. C. J. H., & Ward, P. J. (2016). A global reanalysis of storm surge and extreme sea levels. Nature Communications, 7(7:11969), 1&#8211;11.</p>