A Mixed-Method Analysis of Schedule and Cost Growth in Defense Acquisition Programs

2021 ◽  
Author(s):  
Atharva Hans ◽  
Ashish M. Chaudhari ◽  
Ilias Bilionis ◽  
Jitesh H. Panchal
Keyword(s):  
Mixed Method ◽  
Large Scale ◽  
Acquisition Time ◽  
Defense Acquisition ◽  
Starting Point ◽  
Cost Growth ◽  
Access Database ◽  
Financial Characteristics ◽  
Acquisition Processes ◽  
Method Analysis

Abstract Cost and schedule overruns are common in the procurement of large-scale defense acquisition programs. Current work focuses on identifying the root causes of cost growth and schedule delays in the defense acquisition programs. There is need for a mix of quantitative and qualitative analysis of cost and schedule overruns which takes into account program factor such as, technology maturity, design maturity, initial acquisition time, and program complexity. Such analysis requires an easy to access database for program-specific data about how an acquisition programs’ technical and financial characteristics vary over the time. To fulfill this need, the objective of this paper is twofold: (i) to develop a database of major US defense weapons programs which includes details of the technical and financial characteristics and how they vary over time, and (ii) to test various hypotheses about the interdependence of such characteristics using the collected data. To achieve the objective, we use a mixed-method analysis on schedule and cost growth data available in the U.S. Government Accountability Office’s (GAO’s) defense acquisitions annual assessments during the period 2003–2017. We extracted both analytical and textual data from original reports into Excel files and further created an easy to access database accessible from a Python environment. The analysis reveals that technology immaturity is the major driver of cost and schedule growth during the early stages of the acquisition programs while technical inefficiencies drive cost overruns and schedule delays during the later stages. Further, we find that the acquisition programs with longer initial length do not necessarily have higher greater cost growth. The dataset and the results provide a useful starting point for the research community for modeling cost and schedule overruns, and for practitioners to inform their systems acquisition processes.

scholarly journals Bringing Organizations Back in: Going from Healthy Work to Healthy Workplaces

2019 ◽  
Author(s):  
Malin Bolin ◽  
Gunilla Olofsdotter
Keyword(s):  
Working Conditions ◽  
Mixed Method ◽  
Working Life ◽  
Organizational Analysis ◽  
Starting Point ◽  
Different Types ◽  
Healthy Work ◽  
And Control ◽  
Method Analysis ◽  
Occupational Health Research

The aim of this article is to discuss how the concept of inequality regimes can contribute to theoretical and methodological advances in occupational health research. We posit the mutual advantages of bringing together feminist intersectional analysis of inequality in working life with studies of working conditions and health. The job demands and control model (JDC) is used as a starting point for the discussion. Reintegration of organizational analysis into studies of working conditions and health is warranted, as organizations influence how working conditions are distributed and individuals are stratified in the labor market. We refer to that development as going from healthy work to healthy workplaces. We discuss how the concept of inequality regimes is open for mixed method analysis and how it can be used as a theoretical framework for unraveling the ways in which inequalities in working conditions and health are (re)created in different types of organizations.

Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform

2019 ◽  
Vol 22 (5) ◽  
pp. 346-354
Author(s):  
Yan A. Ivanenkov ◽  
Renat S. Yamidanov ◽  
Ilya A. Osterman ◽  
Petr V. Sergiev ◽  
Vladimir A. Aladinskiy ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Large Scale ◽  
Underlying Mechanism ◽  
Luciferase Assay ◽  
Reporter System ◽  
E Coli ◽  
Starting Point ◽  
High Concentrations ◽  
Mic Value

Aim and Objective: Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was undertaken to identify novel molecules with antibacterial activity. Materials and Methods: Using our unique double-reporter system, in-house large-scale HTS campaign was conducted for the identification of antibacterial potency of small-molecule compounds. The construction allows us to visually assess the underlying mechanism of action. After the initial HTS and rescreen procedure, luciferase assay, C14-test, determination of MIC value and PrestoBlue test were carried out. Results: HTS rounds and rescreen campaign have revealed the antibacterial activity of a series of Nsubstituted triazolo-azetidines and their isosteric derivatives that has not been reported previously. Primary hit-molecule demonstrated a MIC value of 12.5 µg/mL against E. coli Δ tolC with signs of translation blockage and no SOS-response. Translation inhibition (26%, luciferase assay) was achieved at high concentrations up to 160 µg/mL, while no activity was found using C14-test. The compound did not demonstrate cytotoxicity in the PrestoBlue assay against a panel of eukaryotic cells. Within a series of direct structural analogues bearing the same or bioisosteric scaffold, compound 2 was found to have an improved antibacterial potency (MIC=6.25 µg/mL) close to Erythromycin (MIC=2.5-5 µg/mL) against the same strain. In contrast to the parent hit, this compound was more active and selective, and provided a robust IP position. Conclusion: N-substituted triazolo-azetidine scaffold may be used as a versatile starting point for the development of novel active and selective antibacterial compounds.

scholarly journals Urban Policies and Large Projects in Central City Areas: The Example of Madrid (Spain)

Urban Science ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 42
Author(s):  
Dolores Brandis García
Keyword(s):  
Urban Planning ◽  
20Th Century ◽  
Large Scale ◽  
Central City ◽  
Global Market ◽  
Late 20Th Century ◽  
Public And Private ◽  
Urban Policies ◽  
Starting Point ◽  
The City

Since the late 20th century major, European cities have exhibited large projects driven by neoliberal urban planning policies whose aim is to enhance their position on the global market. By locating these projects in central city areas, they also heighten and reinforce their privileged situation within the city as a whole, thus contributing to deepening the centre–periphery rift. The starting point for this study is the significance and scope of large projects in metropolitan cities’ urban planning agendas since the final decade of the 20th century. The aim of this article is to demonstrate the correlation between the various opposing conservative and progressive urban policies, and the projects put forward, for the city of Madrid. A study of documentary sources and the strategies deployed by public and private agents are interpreted in the light of a process during which the city has had a succession of alternating governments defending opposing urban development models. This analysis allows us to conclude that the predominant large-scale projects proposed under conservative policies have contributed to deepening the centre–periphery rift appreciated in the city.

Commentary on Chaplain-Physician Interactions From the Chaplain’s Perspective: A Mixed Method Analysis

2021 ◽  
pp. 104990912110030
Author(s):  
Rev George Handzo ◽  
Rev Brian Hughes
Keyword(s):  
Best Practices ◽  
Health System ◽  
Patient Care ◽  
Health Systems ◽  
Mixed Method ◽  
Effective Strategies ◽  
Optimal Patient Care ◽  
Relationship Of ◽  
The Relationship ◽  
Method Analysis

Gomez and her colleagues have presented a helpful study of the relationship of the chaplains in her health system to physicians which highlights several barriers to a well-integrated relationship and thus to more optimal patient care. We have seen these same barriers as we have consulted with health systems nationally and have also identified many best practices that mediate or even eliminate many of these barriers. This commentary describes some of what we have seen as chaplain-generated causes of those barriers and effective strategies that have been employed to overcome them. We also provide some resources for chaplains who wish to institute some of these best practices themselves.

scholarly journals Contracting in land and natural resources: a tale of exclusion

2021 ◽  
Vol 17 (1) ◽  
pp. 145-153
Author(s):  
Federica Violi
Keyword(s):  
Natural Resources ◽  
Large Scale ◽  
Sustainable Development Goals ◽  
Host Countries ◽  
Developmental Needs ◽  
Starting Point ◽  
The World ◽  
Development Goals ◽  
Short Essay ◽  
Public Environment

By browsing the website of Land Matrix, one can measure the extent of land-related large-scale investments in natural resources (LRINRs) and place it on the world map. At the time of writing, the extent of these investments covers an area equal to the surfaces of Spain and Portugal together – or, for football fans, around 60 million football pitches. These investment operations have often been saluted as instrumental to achieve the developmental needs of host countries and as the necessary private counterpart to state (and interstate) efforts aimed at (sustainable) development goals. Yet, the realities on the ground offer a scenario characterised by severe instances of displacement of indigenous or local communities and environmental disruptions. The starting point of this short essay is that these ‘externalities’ are generated through the legal construct enabling the implementation of these investment operations. As such, this contribution lies neatly in the line of research set forth in the excellent books of Kinnari Bhatt and Jennifer Lander, from the perspective of both the development culture shaping these investment operations and the private–public environment in which these are situated. The essay tries and dialogues with both components, while focusing at a metalevel on the theoretical shifts potentially geared to turn a ‘tale of exclusion’ into a ‘tale of inclusion’.

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