Open-access database of literature derived drug-related Torsade de Pointes cases

Since an introduction of an ICH guidance in 2005, no new drugs were withdrawn from the market because of the causation of Torsade de Pointes (TdP). However, the risk of TdP is still a concern for marketed drugs. TdP is a type of polymorphic ventricular tachycardia which may lead to sudden cardiac death. QT/QTc interval prolongation is considered a sensitive, but not specific biomarker. To improve the effectiveness of studies’ workflow related to TdP risk prediction we created an extensive, structured, open-access database of drug-related TdP cases. PubMed, Google Scholar bibliographic databases, and the Internet, via the Google search engine, were searched to identify eligible reports. A total of 424 papers with a description of 634 case reports and observational studies were included. Each paper was manually examined and listed with up to 53 variables related to patient/population characteristics, general health parameters, used drugs, laboratory measurements, ECG results, clinical management, and its outcomes, as well as suspected drug’s properties and its FDA adverse reaction reports. The presented database may be considered as an extension of the recently developed and published database of drug cardiac safety-related information, part of the tox-portal project providing resources for cardiac toxicity assessment.

An Open-Access Database for the Evaluation of Cardio-Mechanical Signals From Patients With Valvular Heart Diseases

This paper describes an open-access database for seismo-cardiogram (SCG) and gyro-cardiogram (GCG) signals. The archive comprises SCG and GCG recordings sourced from and processed at multiple sites worldwide, including Columbia University Medical Center and Stevens Institute of Technology in the United States, as well as Southeast University, Nanjing Medical University, and the first affiliated hospital of Nanjing Medical University in China. It includes electrocardiogram (ECG), SCG, and GCG recordings collected from 100 patients with various conditions of valvular heart diseases such as aortic and mitral stenosis. The recordings were collected from clinical environments with the same types of wearable sensor patch. Besides the raw recordings of ECG, SCG, and GCG signals, a set of hand-corrected fiducial point annotations is provided by manually checking the results of the annotated algorithm. The database also includes relevant echocardiogram parameters associated with each subject such as ejection fraction, valve area, and mean gradient pressure.

A Mixed-Method Analysis of Schedule and Cost Growth in Defense Acquisition Programs

Cost and schedule overruns are common in the procurement of large-scale defense acquisition programs. Current work focuses on identifying the root causes of cost growth and schedule delays in the defense acquisition programs. There is need for a mix of quantitative and qualitative analysis of cost and schedule overruns which takes into account program factor such as, technology maturity, design maturity, initial acquisition time, and program complexity. Such analysis requires an easy to access database for program-specific data about how an acquisition programs’ technical and financial characteristics vary over the time. To fulfill this need, the objective of this paper is twofold: (i) to develop a database of major US defense weapons programs which includes details of the technical and financial characteristics and how they vary over time, and (ii) to test various hypotheses about the interdependence of such characteristics using the collected data. To achieve the objective, we use a mixed-method analysis on schedule and cost growth data available in the U.S. Government Accountability Office’s (GAO’s) defense acquisitions annual assessments during the period 2003–2017. We extracted both analytical and textual data from original reports into Excel files and further created an easy to access database accessible from a Python environment. The analysis reveals that technology immaturity is the major driver of cost and schedule growth during the early stages of the acquisition programs while technical inefficiencies drive cost overruns and schedule delays during the later stages. Further, we find that the acquisition programs with longer initial length do not necessarily have higher greater cost growth. The dataset and the results provide a useful starting point for the research community for modeling cost and schedule overruns, and for practitioners to inform their systems acquisition processes.

Sistem Pendukung Keputusan Untuk Menentukan Pelanggan Terbaik Pada Pizza Oei-Oei Medan Menggunakan Metode SAW

The management of Pizza Oei-Oei Medan does not yet have a standard system in determining the best customer.m So far, this has been done randomly and without a structure in determining the best customer. Not fair to other customers. It takes a decision support system to determine the best customers who can make decisions from various alternatives and existing criteria in determining the best customers fairly. The method used is SAW (Simple Additive Weighting). SAW is a method that can determine the weight value for each attribute, then proceed with a ranking process that will select the best alternative from a number of alternatives. SAW method can be implemented to find out the best customers based on the criteria and weights that are determined correctly. This research is to determine the best customers at Pizza Oei-Oei Medan. The system is built with Visual Basic Studio programming language with Microsoft Access database.

Historical collections of vascular plants in the Korean Peninsula by three major collectors in the early 20th century: U. J. Faurie, E. J. Taquet and E. H. Wilson

The digitisation of historical collections aims to increase global access to scientific artifacts, especially those from currently inaccessible areas. Historical collections from North Korea deposited at foreign herbaria play a fundamental role in biodiversity transformation patterns. However, the biodiversity pattern distribution in this region remains poorly understood given the severe gaps in available geographic species distribution records. Access to a dominant proportion of primary biodiversity data remains difficult for the broader scientific and environmental community. The digitisation of foreign collectors’ botanical collections of around 60,000 specimens from the Korean Peninsula before World War II is ongoing. In this paper, we aim to fill this gap by developing the first comprehensive, open-access database of biodiversity records for the Korean Peninsula. This paper provides a quantitative and general description of the specimens that Urbain Jean Faurie, Emile Joseph Taquet and Ernest Henry Wilson have collected and are kept in several herbaria. An open-access database of biodiversity records provides a simple guide to georeferencing historical collections. The first set describes E. H. Wilson’s collection of woody plants collected in the Korean Peninsula and preserved at the Harvard University Herbaria (A). This set includes 1,087 records collected from 1917 to 1918. The other collections contain specimens collected by E. J. Taquet (4,727 specimens from Quelpaert (Jeju), 1907–1914) and U. J. Faurie (3,659 specimens from North Korea and Quelpaert, 1901, 1906 and 1907). For each specimen, we recorded the species name, locality indication, collection date, collector, ecology and revision label. This set contains more than 9,400 specimens, with 22% of vascular plants from North Korea and 66% from Quelpaert (Jeju) Island. In these collections, we included some images that correspond to the specimens in this dataset.

A Novel Approach for Developing Web Blog APP

The main aim of this project is to provide data to students in only one site. Students can gather the information from one site as well as give their feedback and create their own blog. Students can post their views and thought and analyse themselves. Besides all such core functionalities, the application also includes features like FAQ, request, feedback etc. so as to provide a satisfactory user experience. The homepage will list all blog posts, and there will be a dedicated detail page for each individual post. A blog is a great addition to any personal portfolio site. Whether you update it monthly or weekly, it’s a great place to share your knowledge as you learn. If user wants to access database and want to post a blog they have to sign in that they have created. In this section, you’re going to build a fully functioning blog that will allow you to perform the following tasks like create, update, and delete blog posts, display posts to the user as either an index view or a detail view and assign categories to posts and allow users to comment on posts.

An Open-Access Simultaneous Electrocardiogram and Phonocardiogram Database

An open-access database consisting of simultaneous electrocardiogram (ECG), phonocardiogram (ECG) recordings and excess auxiliary channels for recording environmental audio noise is introduced. The database has been acquired during a stress-test experiment from healthy young adults. The sample-wise synchrony between the ECG and PCG channel provides an interesting insight into the inter-relationship between the mechanical and electrical mechanisms of the heart under rest and physical activity.

Historical collections of vascular plants in the Korean Peninsula by three major collectors in the early 20th century: U. J. Faurie, E. J. Taquet, and E. H. Wilson

The digitization of historical collections aims to increase global access to scientific artifacts, especially those from currently inaccessible areas. Historical collections from North Korea deposited at foreign herbaria play a fundamental role in biodiversity transformation patterns. However, the biodiversity pattern distribution in this region remains poorly understood given the severe gaps in available geographic species distribution records. Access to a dominant proportion of primary biodiversity data remains difficult for the broader scientific and environmental community. The digitization of foreign collectors’ botanical collections of around 60,000 specimens from the Korean Peninsula before World War II is ongoing. In this paper, we aim to fill this gap by developing the first comprehensive, open-access database of biodiversity records for the Korean Peninsula. This paper provides a quantitative and general description of the specimens that Urbain Jean Faurie, Emile Joseph Taquet, and Ernest Henry Wilson kept in several herbaria. An open-access database of biodiversity records provides a simple guide to georeferencing historical collections. The first dataset described E. H. Wilson’s collection of woody plants in the Korean Peninsula preserved at the Harvard University Herbaria (A). This includes 1,087 records collected from 1917 to 1918. The other collections contained specimens by E. J. Taquet (4,727 specimens from Quelpaert, 1907–1914) and U. J. Faurie (3,659 specimens from North Korea and Quelpaert, 1901, 1906, and 1907). For each specimen, we recorded the species name, locality indication, collection date, collector, ecology, and revision label. This dataset contained more than 9,400 specimens, with 22% of vascular plants from North Korea and 66% from Quelpaert (Jeju) island. In these collections, we included some images that correspond to the specimens in this dataset.