Novel Experimental-Computational Method for Quantitative Applications in Electronic Packaging

Author(s):  
Cosme Furlong ◽  
Ryszard J. Pryputniewicz

Abstract Rapid advances in microelectronics require design and optimization of components and packages, for new and ever more demanding applications, in relatively short periods of time while satisfying electrical, thermal, and mechanical specifications, as well as cost and manufacturability expectations. In addition, reliability and durability have to be taken into consideration. As a consequence, some of the most sophisticated analytical, computational, and experimental methods are being used for development, optimization, and quantitative characterization of electronic packages. In this paper, a novel experimental-computational method, based on combined use of recent advances in laser-based optics and computational modeling, is described and its application is demonstrated by case studies of microelectronic components subjected to electro-thermo-mechanical loads. Results of these studies show that this methodology provides an effective engineering tool for nondestructive testing (NDT) applications in electronic packaging and provides indispensable quantitative data for development, optimization, and applications in electronic packaging.

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17567-17573 ◽  
Author(s):  
Haoxi Ben ◽  
Jack R. Ferrell III

The investigation on time-dependent changes when using 31P NMR to analyze pyrolysis bio-oils has been accomplished and the proposed application of this method is essential to achieve reliable quantitative data.


Author(s):  
Cosme Furlong ◽  
Ryszard J. Pryputniewicz

With the microelectronics industry being one of the most dynamic, in terms of new technologies, electronic packages have to be designed and optimized for new and ever more demanding applications in relatively short periods of time. In addition, for certain applications, the nondestructive testing (NDT) of electronic packages may be needed, especially for applications requiring noninvasive, full-field-of-view, real-time testing the behavior of a specific package subjected to actual operating conditions. This type of NDT can be accomplished by application of optical techniques and, in particular, speckle phase correlation techniques in the form of optoelectronic holography (OEH). In this paper, advanced OEH techniques are described and representative applications of OEH for the effective characterization of microelectronic components and packages are presented.


2013 ◽  
Vol 24 (6) ◽  
pp. 757-767 ◽  
Author(s):  
Marco Fritzsche ◽  
Alexandre Lewalle ◽  
Tom Duke ◽  
Karsten Kruse ◽  
Guillaume Charras

The cell cortex is a thin network of actin, myosin motors, and associated proteins that underlies the plasma membrane in most eukaryotic cells. It enables cells to resist extracellular stresses, perform mechanical work, and change shape. Cortical structural and mechanical properties depend strongly on the relative turnover rates of its constituents, but quantitative data on these rates remain elusive. Using photobleaching experiments, we analyzed the dynamics of three classes of proteins within the cortex of living cells: a scaffold protein (actin), a cross-linker (α-actinin), and a motor (myosin). We found that two filament subpopulations with very different turnover rates composed the actin cortex: one with fast turnover dynamics and polymerization resulting from addition of monomers to free barbed ends, and one with slow turnover dynamics with polymerization resulting from formin-mediated filament growth. Our data suggest that filaments in the second subpopulation are on average longer than those in the first and that cofilin-mediated severing of formin-capped filaments contributes to replenishing the filament subpopulation with free barbed ends. Furthermore, α-actinin and myosin minifilaments turned over significantly faster than F-actin. Surprisingly, only one-fourth of α-actinin dimers were bound to two actin filaments. Taken together, our results provide a quantitative characterization of essential mechanisms under­lying actin cortex homeostasis.


Author(s):  
А.В. Белашов ◽  
А.А. Жихорева

A novel method for the quantitative characterization of fixed histological samples based on the statistical analysis of their phase images obtained using digital holographic microscopy is developed and presented. The proposed approach allows for fully automated processing of reconstructed phase images and obtaining quantitative data of morphological and optical characteristics of histological tissues structures. The method was validated on three histological samples of different types of tissues: ciliated columnar epithelium, elastic cartilage, and liver.


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