High-Intensity Targeted Cavitation as a More Efficient and Safer Approach to Treat Kidney Stones

2014 ◽  
Author(s):  
Steven Dion ◽  
Louis-Philippe Riel ◽  
Michael W. Sourial ◽  
Martin Brouillette
Keyword(s):  
Shock Wave ◽  
Real Time ◽  
Kidney Stones ◽  
High Intensity ◽  
Focal Point ◽  
Ex Vivo ◽  
Artificial Kidney ◽  
Invasive Treatment ◽  
Non Invasive

An apparatus to provide a safer and more efficient non-invasive treatment of kidney stones is under development. The proposed non-invasive alternative is to produce a tightly focused high-intensity cavitation cloud right at the stone; the cloud being electronically steerable in real time to compensate for the respiratory movements which would significantly reduce the exposition of healthy tissues to damaging shock waves. The piloted cloud is produced by 19 independent novel shock wave generators that are geometrically oriented towards a single focal point. The real-time steering is accomplished by applying different emission delays between the shock wave generators. The steering capability of the 19-channel prototype was monitored in vitro using a pressure sensor and kidney stone analogs. Promising tests were also conducted on ex-vivo pigs to measure the erosion rate of implanted artificial kidney stones.

scholarly journals Non-invasive, real-time reporting drug release in vitro and in vivo

2015 ◽  
Vol 51 (32) ◽  
pp. 6948-6951 ◽  
Author(s):  
Yanfeng Zhang ◽  
Qian Yin ◽  
Jonathan Yen ◽  
Joanne Li ◽  
Hanze Ying ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Reporting System ◽  
Real Time Monitoring ◽  
Near Infrared Fluorescence ◽  
Non Invasive ◽  
Fluorescence Dye

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

scholarly journals Real-Time Wireless Platform for In Vivo Monitoring of Bone Regeneration

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4591 ◽  
Author(s):  
Pablo Blázquez-Carmona ◽  
Manuel Sanchez-Raya ◽  
Juan Mora-Macías ◽  
Juan Antonio Gómez-Galán ◽  
Jaime Domínguez ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Real Time ◽  
Ex Vivo ◽  
Low Cost ◽  
Bone Lengthening ◽  
Bone Callus ◽  
Reliable Solution ◽  
Regeneration Processes

For the monitoring of bone regeneration processes, the instrumentation of the fixation is an increasingly common technique to indirectly measure the evolution of bone formation instead of ex vivo measurements or traditional in vivo techniques, such as X-ray or visual review. A versatile instrumented external fixator capable of adapting to multiple bone regeneration processes was designed, as well as a wireless acquisition system for the data collection. The design and implementation of the overall architecture of such a system is described in this work, including the hardware, firmware, and mechanical components. The measurements are conditioned and subsequently sent to a PC via wireless communication to be in vivo displayed and analyzed using a developed real-time monitoring application. Moreover, a model for the in vivo estimation of the bone callus stiffness from collected data was defined. This model was validated in vitro using elastic springs, reporting promising results with respect to previous equipment, with average errors and uncertainties below 6.7% and 14.04%. The devices were also validated in vivo performing a bone lengthening treatment on a sheep metatarsus. The resulting system allowed the in vivo mechanical characterization of the bone callus during experimentation, providing a low-cost, simple, and highly reliable solution.

scholarly journals Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

2009 ◽  
Vol 8 (24) ◽  
pp. 2398-2405 ◽  
Author(s):  
Chuanxing Li ◽  
Weidong Zhang ◽  
Rong Zhang ◽  
Ming Zhao ◽  
Zilin Huang ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Malignant Tumors ◽  
High Intensity Focused Ultrasound ◽  
Invasive Treatment ◽  
Non Invasive

High-intensity focused ultrasound in breast pathology: non-invasive treatment of benign and malignant lesions

2014 ◽  
Vol 12 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Beatrice Cavallo Marincola ◽  
Federica Pediconi ◽  
Michele Anzidei ◽  
Elena Miglio ◽  
Luisa Di Mare ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Invasive Treatment ◽  
Breast Pathology ◽  
Non Invasive ◽  
Malignant Lesions

Long-term evaluation of extracorporeal shock wave lithotripsy in the treatment of salivary stones

2007 ◽  
Vol 122 (1) ◽  
pp. 65-71 ◽  
Author(s):  
S Schmitz ◽  
P Zengel ◽  
I Alvir ◽  
M Andratschke ◽  
A Berghaus ◽  
...  
Keyword(s):  
Shock Wave ◽  
Extracorporeal Shock Wave Lithotripsy ◽  
Shock Wave Lithotripsy ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Extracorporeal Shock Wave ◽  
Stone Treatment ◽  
Term Evaluation ◽  
Average Size

AbstractExtracorporeal shock wave lithotripsy is a rather new therapeutical method in the treatment of sialolithiasis. The objective was to evaluate retrospectively the results of the extracorporeal shock wave lithotripsy therapy performed with a Minilith SL 1 lithotripter on 167 out-patients with symptomatic stones (average size 5.94 mm) of the salivary glands over an observation period of seven years. A successful treatment with total stone disintegration was achieved in 51 (31 per cent) patients. In 92 (55 per cent) patients treatment was partially successful, with disappearance of the symptoms but a sonographically still identifiable stone. Treatment failure occurred in 24 (14 per cent) patients who then underwent surgery. The mean follow-up period was 35.6 months (minimum three, maximum 83), after which 83.2 per cent of the initially successfully treated patients were still free of symptoms.Therefore, extracorporeal shock wave lithotripsy, as a non-invasive treatment alternative with few side effects, is an efficient technique for the therapy of sialolithiasis in selected patients.

Evolution Profile for Assessing Drug-Induced Arrhythmia Using Multifunctional Cardiomyocyte-Based Biosensor

2014 ◽  
Vol 1058 ◽  
pp. 339-343
Author(s):  
Tian Xing Wang ◽  
Kai Qi Su ◽  
Ning Hu ◽  
Ping Wang
Keyword(s):  
Real Time ◽  
Cell Analysis ◽  
Drug Induced ◽  
Non Invasive ◽  
Myocyte Function ◽  
Beating Rate ◽  
Growth Evolution

In vitro rapid cell-based bioassay is one of the effective methods to evaluate cardio-myocyte function by characteristics of beating rate, contractility, and toxicity. In this study, rapid profile assessing drug-induced arrhythmia was studied by treating cardiomyocyte-based biosensor with some drugs, which resulted in compound-specific changes in the cardiomyocyte beating evolution profiles and growth evolution profiles. Also, rapid profile assessment of cardiomyocyte-based biosensor was also determined by several types of compoundsFrom the compound experiment results, cardiomyocyte-based biosensor with real-time cell analysis technology can monitor the cardiomyocyte beating status in a non-invasive way and indicate the potential of drug-induced arrhythmia.

scholarly journals Supramolecular Encapsulation of Small-Ultra Red Fluorescent Proteins in Virus-Like Nanoparticles for Non-Invasive In Vivo Imaging Agents

2020 ◽  
Author(s):  
Fabian C. Herbert ◽  
Olivia Brohlin ◽  
Tyler Galbraith ◽  
Candace Benjamin ◽  
Cesar A. Reyes ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Ex Vivo ◽  
Imaging Agents ◽  
Non Invasive ◽  
Red Fluorescent Proteins ◽  
Ex Vivo Imaging

<div> <div> <div> <p>Icosahedral virus-like particles (VLPs) derived from bacteriophages Qβ and PP7 encapsulating small-ultra red fluorescent protein (smURFP) were produced using a versatile supramolecualr capsid dissassemble-reassemble approach. The generated fluorescent VLPs display identical structural properties to their non-fluorescent analogs. Encapsulated smURFP shows indistinguishable photochemical properties to its unencapsulated counterpart, exhibits outstanding stability towards pH, and produces bright in vitro images following phagocytosis by macrophages. In vivo imaging allows biodistribution to be imaged at different time points. Ex vivo imaging of intravenously administered encapsulated smURFP reveleas localization in the liver and </p> </div> </div> <div> <div> <p>kidneys after 2 h blood circulation and substantial elimination constructs as non-invasive in vivo imaging agents. </p> </div> </div> </div>

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