scholarly journals A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases

Biomaterials ◽  
2018 ◽  
Vol 165 ◽  
pp. 25-38 ◽  
Author(s):  
Wei Shan Lim ◽  
Kenneth Chen ◽  
Tsung Wen Chong ◽  
Gordon Minru Xiong ◽  
William R. Birch ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ureteric Stent ◽  
Drug Eluting ◽  
Localized Drug Delivery

Transport in Pulsatile Axisymmetric Stented Arterial Models From Location-Dependent Variations in Permeability and Mechanical Properties

2011 ◽  
Author(s):  
Joseph T. Keyes ◽  
Bruce R. Simon ◽  
Jonathan P. Vande Geest
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Relative Influence ◽  
Drug Eluting Stents ◽  
Diffusive Transport ◽  
Antiproliferative Effects ◽  
Drug Eluting ◽  
Tissue System ◽  
Localized Drug Delivery ◽  
Insight Into

Drug-eluting stents (DESs) perform their antiproliferative effects through the use of localized drug delivery. The delivery may be computationally modeled to determine efficacy of the DES-tissue system and utilizes coupled convective and diffusive transport. Since the movement of solutes through the wall is via the coupled effects of convective and diffusive transport, the relative influence of these factors provides insight into the governing forces of localized DES drug delivery [1].

Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants

2020 ◽  
Vol 27 (6) ◽  
pp. 854-902 ◽  
Author(s):  
Raluca Ion ◽  
Madalina Georgiana Necula ◽  
Anca Mazare ◽  
Valentina Mitran ◽  
Patricia Neacsu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tio2 Nanotubes ◽  
Therapeutic Agent ◽  
Bone Defects ◽  
Delivery Systems ◽  
Antimicrobial Compounds ◽  
Bone Implant ◽  
Bioactive Agents ◽  
Localized Drug Delivery ◽  
Regeneration Of Bone

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.

scholarly journals Smart Packaging: A Novel Technique For Localized Drug Delivery

2009 ◽  
Vol 96 (3) ◽  
pp. 687a ◽  
Author(s):  
Eva Christabel Williams ◽  
Ryan Toomey ◽  
Norma Alcantar
Keyword(s):  
Drug Delivery ◽  
Smart Packaging ◽  
Novel Technique ◽  
Localized Drug Delivery

scholarly journals Drug-eluting embolic microspheres for local drug delivery – State of the art

2017 ◽  
Vol 262 ◽  
pp. 127-138 ◽  
Author(s):  
Katrin Fuchs ◽  
Rafael Duran ◽  
Alban Denys ◽  
Pierre E. Bize ◽  
Gerrit Borchard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
State Of The Art ◽  
Local Drug Delivery ◽  
Drug Eluting

scholarly journals Biopolymer Hydrogel Scaffolds Containing Doxorubicin as A Localized Drug Delivery System for Inhibiting Lung Cancer Cell Proliferation

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3580
Author(s):  
Chuda Chittasupho ◽  
Jakrapong Angklomklew ◽  
Thanu Thongnopkoon ◽  
Wongwit Senavongse ◽  
Pensak Jantrawut ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Encapsulation Efficiency ◽  
Lung Cancer Cell ◽  
Hydrogel Scaffold ◽  
Hydrogel Scaffolds ◽  
Localized Drug Delivery

A hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy. The encapsulation efficiency and the release profile of doxorubicin from the hydrogel scaffolds were determined using UV-Vis spectrophotometry. The anti-proliferative effect of the scaffolds against the lung cancer cell line was investigated using an MTT assay. The results showed that scaffolds made from different types of natural polymer had different pore configurations and pore sizes. All scaffolds had high encapsulation efficiency and drug-controlled release profiles. The viability and proliferation of A549 cells, treated with gelatin, gelatin/SCMC, and SCMC scaffolds containing doxorubicin significantly decreased compared with control. These hydrogel scaffolds might provide a promising approach for developing a superior localized drug delivery system to kill lung cancer cells.

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