scholarly journals Circulating Tumor Cell Adhesion in Microcirculation

2016 ◽  
Author(s):  
Lanlan Xiao ◽  
Yang Liu ◽  
Shuo Chen ◽  
Bingmei Fu
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Tumor Cell Adhesion

Abstract B46: Biomechanical preconditioning of circulating tumor cell adhesion during metastasis

2016 ◽  
Author(s):  
Adrianne Spencer ◽  
Zhiying Zhu ◽  
Katerina Lee ◽  
Jason Lee ◽  
Chris Spruell ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Tumor Cell Adhesion

Abstract PR08: Biomechanical preconditioning of circulating tumor cell adhesion during metastasis

2016 ◽  
Author(s):  
Adrianne Spencer ◽  
Zhiying Zhu ◽  
Katerina Lee ◽  
Jason Lee ◽  
Chris Spruell ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Tumor Cell Adhesion

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

scholarly journals Tailored chitosan/hyaluronan coatings for tumor cell adhesion: Effects of topography, charge density and surface composition

2019 ◽  
Vol 486 ◽  
pp. 508-518 ◽  
Author(s):  
J.B.M. Rocha Neto ◽  
T.B. Taketa ◽  
R.A. Bataglioli ◽  
S.B. Pimentel ◽  
D.M. Santos ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Charge Density ◽  
Surface Composition ◽  
Tumor Cell Adhesion

scholarly journals Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion

2007 ◽  
Vol 193 (3) ◽  
pp. 331-335 ◽  
Author(s):  
David Yü Greenblatt ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Tumor Cell Adhesion ◽  
Gastrointestinal Carcinoid

scholarly journals Specific Syndecan-1 Domains Regulate Mesenchymal Tumor Cell Adhesion, Motility and Migration

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e14816 ◽  
Author(s):  
Fang Zong ◽  
Eleni Fthenou ◽  
Filip Mundt ◽  
Tünde Szatmári ◽  
Ilona Kovalszky ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Mesenchymal Tumor ◽  
Tumor Cell Adhesion ◽  
And Migration
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